| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/119828 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Parecoxib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| S100A2 | S100 calcium binding protein A2 | 1.24 |
| POF1B | premature ovarian failure, 1B | 1.22 |
| DNAH12 | dynein, axonemal, heavy chain 12 | 0.88 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | 0.86 |
| PCGF5 | polycomb group ring finger 5 | 0.57 |
| MYT1 | myelin transcription factor 1 | 0.5 |
| HIST1H1T | histone cluster 1, H1t | 0.45 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.43 |
| TRAF3IP2 | TRAF3 interacting protein 2 | 0.41 |
| KLHL42 | kelch-like family member 42 | 0.41 |
| CRAMP1 | cramped chromatin regulator homolog 1 | 0.41 |
| EFNB2 | ephrin-B2 | 0.4 |
| TICRR | TOPBP1-interacting checkpoint and replication regulator | 0.4 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.39 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.39 |
| RASSF7 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | 0.39 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.37 |
| CHST7 | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 | 0.37 |
| FAT2 | FAT atypical cadherin 2 | 0.36 |
| MNX1 | motor neuron and pancreas homeobox 1 | 0.36 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.36 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.35 |
| ZNF165 | zinc finger protein 165 | 0.34 |
| TMEM160 | transmembrane protein 160 | 0.34 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.34 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | 0.34 |
| PLPP3 | phospholipid phosphatase 3 | 0.33 |
| WDR54 | WD repeat domain 54 | 0.33 |
| PXDN | peroxidasin | 0.33 |
| SESN2 | sestrin 2 | 0.33 |
| FAM110C | family with sequence similarity 110, member C | 0.32 |
| TYSND1 | trypsin domain containing 1 | 0.32 |
| SGPP1 | sphingosine-1-phosphate phosphatase 1 | 0.32 |
| H1-5 | H1.5 linker histone, cluster member | 0.31 |
| DISP2 | dispatched homolog 2 (Drosophila) | 0.31 |
| MCL1 | myeloid cell leukemia 1 | 0.31 |
| SPATA20 | spermatogenesis associated 20 | 0.31 |
| TMEM39B | transmembrane protein 39B | 0.3 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.3 |
| E2F2 | E2F transcription factor 2 | 0.3 |
| KIAA0556 | KIAA0556 | 0.3 |
| DALRD3 | DALR anticodon binding domain containing 3 | 0.29 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.29 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 0.29 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | 0.29 |
| RPL14 | ribosomal protein L14 | 0.28 |
| HDAC7 | histone deacetylase 7 | 0.28 |
| PLSCR1 | phospholipid scramblase 1 | 0.28 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | 0.28 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | 0.28 |
| TTC31 | tetratricopeptide repeat domain 31 | 0.28 |
| TTN | titin | 0.28 |
| CDC6 | cell division cycle 6 | 0.27 |
| RUNX3 | runt-related transcription factor 3 | 0.27 |
| CFAP410 | cilia and flagella associated protein 410 | 0.27 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 0.27 |
| HDIP1 | HDAC and MIER1 interacting protein 1 | 0.27 |
| ZNF827 | zinc finger protein 827 | 0.27 |
| TMEM64 | transmembrane protein 64 | 0.27 |
| SNRNP48 | small nuclear ribonucleoprotein 48kDa (U11/U12) | 0.27 |
| SYTL4 | synaptotagmin-like 4 | 0.27 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.27 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | 0.27 |
| SIK2 | salt-inducible kinase 2 | 0.26 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.26 |
| ADPRH | ADP-ribosylarginine hydrolase | 0.26 |
| DCAF15 | DDB1 and CUL4 associated factor 15 | 0.26 |
| SP4 | Sp4 transcription factor | 0.26 |
| ATG4A | autophagy related 4A, cysteine peptidase | 0.26 |
| TP53 | tumor protein p53 | 0.26 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.25 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 0.25 |
| PRKD3 | protein kinase D3 | 0.25 |
| KIAA1109 | KIAA1109 | 0.25 |
| RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing | 0.25 |
| LMF1 | lipase maturation factor 1 | 0.25 |
| KMT5A | lysine methyltransferase 5A | 0.25 |
| KLHDC3 | kelch domain containing 3 | 0.25 |
| LRRC45 | leucine rich repeat containing 45 | 0.25 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | 0.25 |
| MAGEA6 | melanoma antigen family A6 | 0.25 |
| UPRT | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | 0.25 |
| IAH1 | isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) | 0.25 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.25 |
| CCNYL1 | cyclin Y-like 1 | 0.25 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.25 |
| H1-3 | H1.3 linker histone, cluster member | 0.24 |
| R3HDM4 | R3H domain containing 4 | 0.24 |
| GIGYF1 | GRB10 interacting GYF protein 1 | 0.24 |
| NEK4 | NIMA-related kinase 4 | 0.24 |
| NCOA7 | nuclear receptor coactivator 7 | 0.24 |
| FCHO1 | FCH domain only 1 | 0.24 |
| TUBD1 | tubulin, delta 1 | 0.24 |
| CPA4 | carboxypeptidase A4 | 0.24 |
| TMCO4 | transmembrane and coiled-coil domains 4 | 0.24 |
| ING4 | inhibitor of growth family, member 4 | 0.24 |
| CDC37 | cell division cycle 37 | 0.23 |
| TOPORS | topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase | 0.23 |
| DNPEP | aspartyl aminopeptidase | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PEX5 | peroxisomal biogenesis factor 5 | -0.94 |
| RAB29 | RAB29, member RAS oncogene family | -0.93 |
| SARDH | sarcosine dehydrogenase | -0.87 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.7 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | -0.67 |
| FN1 | fibronectin 1 | -0.66 |
| PROS1 | protein S (alpha) | -0.59 |
| COX11 | COX11 cytochrome c oxidase copper chaperone | -0.56 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.53 |
| C5ORF51 | chromosome 5 open reading frame 51 | -0.53 |
| DGKE | diacylglycerol kinase, epsilon 64kDa | -0.51 |
| ZFP62 | ZFP62 zinc finger protein | -0.51 |
| BORCS7 | BLOC-1 related complex subunit 7 | -0.51 |
| CD320 | CD320 molecule | -0.51 |
| FBXO17 | F-box protein 17 | -0.5 |
| BANF1 | barrier to autointegration factor 1 | -0.5 |
| SEPTIN5 | septin 5 | -0.5 |
| GRK5 | G protein-coupled receptor kinase 5 | -0.5 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.5 |
| SRD5A3 | steroid 5 alpha-reductase 3 | -0.49 |
| FBXO42 | F-box protein 42 | -0.48 |
| CHKB | choline kinase beta | -0.47 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | -0.47 |
| TNNC2 | troponin C type 2 (fast) | -0.47 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.46 |
| CARD8 | caspase recruitment domain family, member 8 | -0.46 |
| ICOSLG | inducible T-cell co-stimulator ligand | -0.46 |
| FCHO2 | FCH domain only 2 | -0.43 |
| PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | -0.42 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | -0.42 |
| JMJD4 | jumonji domain containing 4 | -0.42 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | -0.41 |
| HOXA9 | homeobox A9 | -0.41 |
| TCTN3 | tectonic family member 3 | -0.41 |
| PRX | periaxin | -0.41 |
| BEND7 | BEN domain containing 7 | -0.41 |
| ACTN4 | actinin, alpha 4 | -0.4 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -0.4 |
| TK2 | thymidine kinase 2, mitochondrial | -0.4 |
| PLEC | plectin | -0.4 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.4 |
| FBXO33 | F-box protein 33 | -0.38 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | -0.38 |
| LYPLA2 | lysophospholipase II | -0.38 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.38 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.37 |
| TCAIM | T cell activation inhibitor, mitochondrial | -0.37 |
| TPM1 | tropomyosin 1 (alpha) | -0.37 |
| SRI | sorcin | -0.37 |
| RPLP1 | ribosomal protein, large, P1 | -0.37 |
| PEF1 | penta-EF-hand domain containing 1 | -0.36 |
| HLA-F | major histocompatibility complex, class I, F | -0.36 |
| RUFY2 | RUN and FYVE domain containing 2 | -0.36 |
| POMP | proteasome maturation protein | -0.35 |
| TRIM44 | tripartite motif containing 44 | -0.35 |
| FUNDC1 | FUN14 domain containing 1 | -0.35 |
| ZNRD2 | zinc ribbon domain containing 2 | -0.35 |
| BCAS2 | breast carcinoma amplified sequence 2 | -0.35 |
| BID | BH3 interacting domain death agonist | -0.35 |
| ACTN3 | actinin, alpha 3 (gene/pseudogene) | -0.35 |
| DXO | decapping exoribonuclease | -0.35 |
| CTTNBP2 | cortactin binding protein 2 | -0.34 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | -0.34 |
| ELAC1 | elaC ribonuclease Z 1 | -0.34 |
| BCL2L12 | BCL2-like 12 (proline rich) | -0.34 |
| BRCA2 | breast cancer 2, early onset | -0.34 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | -0.34 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.34 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.34 |
| UBQLN4 | ubiquilin 4 | -0.34 |
| CEP290 | centrosomal protein 290kDa | -0.33 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | -0.33 |
| RAD54L | RAD54-like (S. cerevisiae) | -0.33 |
| ERICH5 | glutamate-rich 5 | -0.33 |
| ZNF410 | zinc finger protein 410 | -0.33 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.32 |
| TBC1D12 | TBC1 domain family, member 12 | -0.32 |
| ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7 | -0.32 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | -0.32 |
| HYPK | huntingtin interacting protein K | -0.32 |
| NUTF2 | nuclear transport factor 2 | -0.32 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | -0.32 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.31 |
| SUMF1 | sulfatase modifying factor 1 | -0.31 |
| ADIRF | adipogenesis regulatory factor | -0.31 |
| RNF220 | ring finger protein 220 | -0.31 |
| PFDN4 | prefoldin subunit 4 | -0.31 |
| SETD5 | SET domain containing 5 | -0.31 |
| ZNF354A | zinc finger protein 354A | -0.31 |
| YAP1 | Yes-associated protein 1 | -0.3 |
| ENDOV | endonuclease V | -0.3 |
| UBQLN1 | ubiquilin 1 | -0.3 |
| C14ORF93 | chromosome 14 open reading frame 93 | -0.3 |
| GTSF1 | gametocyte specific factor 1 | -0.3 |
| FAM136A | family with sequence similarity 136, member A | -0.3 |
| FBXL4 | F-box and leucine-rich repeat protein 4 | -0.3 |
| COPE | coatomer protein complex, subunit epsilon | -0.29 |
| ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | -0.29 |
| ERH | enhancer of rudimentary homolog (Drosophila) | -0.29 |
| HAS3 | hyaluronan synthase 3 | -0.29 |
