Paricalcitol Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5281104
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Genes

199 proteins with high or low expression in Paricalcitol relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 3.96
GEM GTP binding protein overexpressed in skeletal muscle 2.0
KLK6 kallikrein-related peptidase 6 1.62
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.54
HBA1 hemoglobin, alpha 1 1.33
GATA2 GATA binding protein 2 1.01
EFL1 elongation factor like GTPase 1 0.9
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.9
KLK7 kallikrein-related peptidase 7 0.77
ABHD2 abhydrolase domain containing 2 0.72
FOSL2 FOS-like antigen 2 0.7
GDF15 growth differentiation factor 15 0.66
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 0.66
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.65
WSB2 WD repeat and SOCS box containing 2 0.64
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.64
UPP1 uridine phosphorylase 1 0.64
DDIT4 DNA-damage-inducible transcript 4 0.63
TIMP2 TIMP metallopeptidase inhibitor 2 0.62
CRLF1 cytokine receptor-like factor 1 0.61
ABHD13 abhydrolase domain containing 13 0.57
TPGS2 tubulin polyglutamylase complex subunit 2 0.54
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 0.52
F13A1 coagulation factor XIII, A1 polypeptide 0.48
ACTN3 actinin, alpha 3 (gene/pseudogene) 0.47
ANAPC11 anaphase promoting complex subunit 11 0.46
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.46
ZNF490 zinc finger protein 490 0.46
AFG1L AFG1 like ATPase 0.45
PRELID3B PRELI domain containing 3B 0.45
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted 0.45
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.44
CMC4 C-x(9)-C motif containing 4 0.43
C12ORF66 chromosome 12 open reading frame 66 0.42
FTL ferritin, light polypeptide 0.42
AKR1C3 aldo-keto reductase family 1, member C3 0.41
PLA2G12A phospholipase A2, group XIIA 0.41
ZNF696 zinc finger protein 696 0.4
ZFP36 ZFP36 ring finger protein 0.4
APOE apolipoprotein E 0.39
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.39
THSD4 thrombospondin, type I, domain containing 4 0.39
C5ORF30 chromosome 5 open reading frame 30 0.39
LRRC46 leucine rich repeat containing 46 0.39
AKAP12 A kinase (PRKA) anchor protein 12 0.38
JUNB jun B proto-oncogene 0.38
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 0.38
PPCDC phosphopantothenoylcysteine decarboxylase 0.37
CLGN calmegin 0.37
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.37
GTF2A1 general transcription factor IIA, 1, 19/37kDa 0.36
SLC35F6 solute carrier family 35, member F6 0.36
C18ORF32 chromosome 18 open reading frame 32 0.36
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.36
FTH1 ferritin, heavy polypeptide 1 0.36
PRNP prion protein 0.36
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.36
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 0.36
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.35
KIAA1324L KIAA1324-like 0.35
FOSL1 FOS-like antigen 1 0.35
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) 0.35
TSPAN4 tetraspanin 4 0.35
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.34
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.34
TRIML2 tripartite motif family-like 2 0.34
COL14A1 collagen, type XIV, alpha 1 0.34
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 0.34
TXNRD1 thioredoxin reductase 1 0.34
ZFP36L1 ZFP36 ring finger protein-like 1 0.34
BPTF bromodomain PHD finger transcription factor 0.33
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.33
SCAND1 SCAN domain containing 1 0.33
SOX9 SRY (sex determining region Y)-box 9 0.33
MELTF melanotransferrin 0.33
LAMC2 laminin, gamma 2 0.33
BCDIN3D BCDIN3 domain containing 0.32
PRG4 proteoglycan 4 0.32
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.32
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.32
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.32
RHOF ras homolog family member F (in filopodia) 0.32
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.32
KIAA1671 KIAA1671 0.31
BORCS6 BLOC-1 related complex subunit 6 0.31
ERMARD ER membrane-associated RNA degradation 0.31
MED31 mediator complex subunit 31 0.31
TRIM56 tripartite motif containing 56 0.31
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 0.31
BSG basigin (Ok blood group) 0.3
MYRF myelin regulatory factor 0.3
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.3
MBNL2 muscleblind-like splicing regulator 2 0.3
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.3
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.3
NRXN3 neurexin 3 0.3
PRDM11 PR domain containing 11 0.3
TANGO2 transport and golgi organization 2 homolog (Drosophila) 0.3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.3

low expression

Symbol Name Standardized Value
CKM creatine kinase, muscle -1.65
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) -1.49
RPL26 ribosomal protein L26 -0.97
SET SET nuclear proto-oncogene -0.96
TMEM128 transmembrane protein 128 -0.81
LRRC58 leucine rich repeat containing 58 -0.81
KMT2B lysine (K)-specific methyltransferase 2B -0.77
TNNC2 troponin C type 2 (fast) -0.69
MOCS1 molybdenum cofactor synthesis 1 -0.67
TBC1D12 TBC1 domain family, member 12 -0.66
MAGEF1 melanoma antigen family F1 -0.66
RNF111 ring finger protein 111 -0.63
COA5 cytochrome c oxidase assembly factor 5 -0.63
HFE hemochromatosis -0.6
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -0.57
TMEM63A transmembrane protein 63A -0.56
MPHOSPH9 M-phase phosphoprotein 9 -0.56
UNC93B1 unc-93 homolog B1 (C. elegans) -0.51
ART5 ADP-ribosyltransferase 5 -0.51
ZNF317 zinc finger protein 317 -0.48
MYH13 myosin, heavy chain 13, skeletal muscle -0.48
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -0.48
ZIC2 Zic family member 2 -0.48
HOXB4 homeobox B4 -0.47
VIM vimentin -0.46
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -0.46
MED30 mediator complex subunit 30 -0.46
ZNF761 zinc finger protein 761 -0.45
ZSWIM9 zinc finger SWIM-type containing 9 -0.45
MARK4 MAP/microtubule affinity-regulating kinase 4 -0.45
ATMIN ATM interactor -0.45
GEMIN7 gem (nuclear organelle) associated protein 7 -0.44
MICB MHC class I polypeptide-related sequence B -0.44
RAB6D RAB6D, member RAS oncogene family -0.43
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.43
RGN regucalcin -0.42
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 -0.42
SLC2A4RG SLC2A4 regulator -0.41
SRRD SRR1 domain containing -0.41
CDC25B cell division cycle 25B -0.41
SMIM26 small integral membrane protein 26 -0.41
PEG10 paternally expressed 10 -0.41
LCORL ligand dependent nuclear receptor corepressor-like -0.4
ZNF655 zinc finger protein 655 -0.4
PTPRB protein tyrosine phosphatase, receptor type, B -0.4
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.4
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -0.4
NHSL1 NHS-like 1 -0.4
HOXA7 homeobox A7 -0.39
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.39
MSMO1 methylsterol monooxygenase 1 -0.38
SEPTIN4 septin 4 -0.38
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -0.38
MED12L mediator complex subunit 12-like -0.38
MSX1 msh homeobox 1 -0.37
CFAP410 cilia and flagella associated protein 410 -0.37
DNAL4 dynein, axonemal, light chain 4 -0.37
SUCO SUN domain containing ossification factor -0.37
GLUL glutamate-ammonia ligase -0.37
TEN1 TEN1 CST complex subunit -0.37
RAD51D RAD51 paralog D -0.37
SPPL3 signal peptide peptidase like 3 -0.36
ZNF496 zinc finger protein 496 -0.36
ISCA2 iron-sulfur cluster assembly 2 -0.36
GPI glucose-6-phosphate isomerase -0.36
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.36
RBMX2 RNA binding motif protein, X-linked 2 -0.35
IFI30 interferon, gamma-inducible protein 30 -0.35
MTRF1 mitochondrial translational release factor 1 -0.35
MEGF6 multiple EGF-like-domains 6 -0.34
PCNX1 pecanex 1 -0.34
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) -0.33
FRK fyn-related Src family tyrosine kinase -0.33
LYRM1 LYR motif containing 1 -0.33
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -0.33
APLF aprataxin and PNKP like factor -0.33
EGR1 early growth response 1 -0.32
TMUB1 transmembrane and ubiquitin-like domain containing 1 -0.32
TECR trans-2,3-enoyl-CoA reductase -0.32
PPT2 palmitoyl-protein thioesterase 2 -0.32
SPC24 SPC24, NDC80 kinetochore complex component -0.32
CNPY2 canopy FGF signaling regulator 2 -0.32
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.32
ZNF511 zinc finger protein 511 -0.31
OSGIN2 oxidative stress induced growth inhibitor family member 2 -0.31
ZNF652 zinc finger protein 652 -0.31
ZNF430 zinc finger protein 430 -0.31
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa -0.31
VAMP8 vesicle-associated membrane protein 8 -0.31
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 -0.31
LAMA3 laminin, alpha 3 -0.31
PEX5 peroxisomal biogenesis factor 5 -0.31
RNASEH1 ribonuclease H1 -0.31
METTL9 methyltransferase like 9 -0.31
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.31
KIAA0232 KIAA0232 -0.3
CCND3 cyclin D3 -0.3
AXL AXL receptor tyrosine kinase -0.3
HSPA1L heat shock 70kDa protein 1-like -0.3