Parkinsonism Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Characteristic neurologic anomaly resulting form degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait. (Human Phenotype Ontology, HP_0001300)
External Link https://www.disgenet.org/browser/0/1/0/C0752101
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Genes

43 genes associated with the disease Parkinsonism in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ATP13A2 ATPase type 13A2
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
CTSC cathepsin C
DCTN1 dynactin 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DRD2 dopamine receptor D2
FBXO7 F-box protein 7
GBA glucosidase, beta, acid
GCH1 GTP cyclohydrolase 1
GDNF glial cell derived neurotrophic factor
GSR glutathione reductase
HTRA2 HtrA serine peptidase 2
LRRK2 leucine-rich repeat kinase 2
MAPT microtubule-associated protein tau
MT-CYB cytochrome b
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NGF nerve growth factor (beta polypeptide)
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PDYN prodynorphin
PINK1 PTEN induced putative kinase 1
PNOC prepronociceptin
POLG polymerase (DNA directed), gamma
PRKCD protein kinase C, delta
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PRL prolactin
RAB39B RAB39B, member RAS oncogene family
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC30A10 solute carrier family 30, member 10
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPG11 spastic paraplegia 11 (autosomal recessive)
SYNJ1 synaptojanin 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TH tyrosine hydroxylase
ZNF645 zinc finger protein 645