| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo. (Chemical Entities of Biological Interest Ontology, CHEBI_7936) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/43815 |
| Similar Terms | |
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198 proteins with high or low expression in Paroxetine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TSPAN3 | tetraspanin 3 | 1.43 |
| TMEM260 | transmembrane protein 260 | 1.3 |
| SASH1 | SAM and SH3 domain containing 1 | 1.13 |
| ANTXR2 | anthrax toxin receptor 2 | 1.07 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 1.03 |
| TNNC2 | troponin C type 2 (fast) | 1.0 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.99 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.91 |
| KIZ | kizuna centrosomal protein | 0.86 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.85 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.84 |
| MIEN1 | migration and invasion enhancer 1 | 0.83 |
| MXRA7 | matrix-remodelling associated 7 | 0.82 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.75 |
| ZNF536 | zinc finger protein 536 | 0.7 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.7 |
| DISP2 | dispatched homolog 2 (Drosophila) | 0.69 |
| ARHGEF37 | Rho guanine nucleotide exchange factor (GEF) 37 | 0.67 |
| MCOLN2 | mucolipin 2 | 0.67 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 0.66 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.64 |
| RPAIN | RPA interacting protein | 0.63 |
| AAMDC | adipogenesis associated, Mth938 domain containing | 0.62 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.62 |
| C7 | complement component 7 | 0.61 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.6 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.59 |
| MFAP3 | microfibrillar-associated protein 3 | 0.59 |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.58 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.58 |
| CUTA | cutA divalent cation tolerance homolog (E. coli) | 0.57 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | 0.57 |
| AVEN | apoptosis, caspase activation inhibitor | 0.56 |
| RPL37 | ribosomal protein L37 | 0.55 |
| ENOX2 | ecto-NOX disulfide-thiol exchanger 2 | 0.55 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.54 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.53 |
| KIAA1324L | KIAA1324-like | 0.51 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.51 |
| NENF | neudesin neurotrophic factor | 0.51 |
| GJC1 | gap junction protein, gamma 1, 45kDa | 0.5 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | 0.5 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 0.49 |
| ARG2 | arginase 2 | 0.49 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.48 |
| DDTL | D-dopachrome tautomerase-like | 0.48 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.48 |
| ALPK3 | alpha-kinase 3 | 0.48 |
| DUOX1 | dual oxidase 1 | 0.47 |
| PPP1R3D | protein phosphatase 1, regulatory subunit 3D | 0.46 |
| TMEM135 | transmembrane protein 135 | 0.46 |
| UBQLN1 | ubiquilin 1 | 0.46 |
| CLTA | clathrin, light chain A | 0.45 |
| NCOA4 | nuclear receptor coactivator 4 | 0.45 |
| RIOX1 | ribosomal oxygenase 1 | 0.44 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.44 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.44 |
| RFX7 | regulatory factor X, 7 | 0.44 |
| ZNF189 | zinc finger protein 189 | 0.44 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.43 |
| FADS1 | fatty acid desaturase 1 | 0.43 |
| MVK | mevalonate kinase | 0.43 |
| SLC2A4RG | SLC2A4 regulator | 0.42 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | 0.42 |
| H1-0 | H1.0 linker histone | 0.42 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | 0.42 |
| CD63 | CD63 molecule | 0.42 |
| TLCD4 | TLC domain containing 4 | 0.42 |
| SPHK2 | sphingosine kinase 2 | 0.42 |
| SLC22A18 | solute carrier family 22, member 18 | 0.41 |
| APOB | apolipoprotein B | 0.41 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.41 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.41 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.41 |
| MED8 | mediator complex subunit 8 | 0.41 |
| GATA2 | GATA binding protein 2 | 0.41 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.41 |
| PLPP2 | phospholipid phosphatase 2 | 0.41 |
| KLHL2 | kelch-like family member 2 | 0.4 |
| ZNF362 | zinc finger protein 362 | 0.4 |
| DFFB | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 0.4 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | 0.4 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 0.4 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.4 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.4 |
| ADIPOR1 | adiponectin receptor 1 | 0.39 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.39 |
| WNK2 | WNK lysine deficient protein kinase 2 | 0.39 |
| RRN3 | RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) | 0.39 |
| NUCB1 | nucleobindin 1 | 0.39 |
| BCAS2 | breast carcinoma amplified sequence 2 | 0.39 |
| ANKRD18B | ankyrin repeat domain 18B | 0.38 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | 0.38 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.38 |
| NUP62 | nucleoporin 62kDa | 0.38 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.38 |
| PARP16 | poly (ADP-ribose) polymerase family, member 16 | 0.38 |
| SQLE | squalene epoxidase | 0.38 |
| HIST2H2AB | histone cluster 2, H2ab | 0.38 |
| FAM171A2 | family with sequence similarity 171, member A2 | 0.38 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH8 | myosin, heavy chain 8, skeletal muscle, perinatal | -2.78 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | -1.16 |
| ZG16B | zymogen granule protein 16B | -1.09 |
| DCHS1 | dachsous cadherin-related 1 | -1.04 |
| CCDC112 | coiled-coil domain containing 112 | -0.99 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.96 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -0.77 |
| NAAA | N-acylethanolamine acid amidase | -0.75 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.74 |
| HAL | histidine ammonia-lyase | -0.73 |
| TDRD6 | tudor domain containing 6 | -0.73 |
| SHROOM2 | shroom family member 2 | -0.67 |
| SLC10A4 | solute carrier family 10, member 4 | -0.66 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.61 |
| TFR2 | transferrin receptor 2 | -0.6 |
| ZNF525 | zinc finger protein 525 | -0.6 |
| ZNF714 | zinc finger protein 714 | -0.6 |
| GRB14 | growth factor receptor-bound protein 14 | -0.57 |
| LYRM1 | LYR motif containing 1 | -0.56 |
| MT-ATP6 | ATP synthase F0 subunit 6 | -0.56 |
| PLIN2 | perilipin 2 | -0.55 |
| MCOLN1 | mucolipin 1 | -0.54 |
| GSTZ1 | glutathione S-transferase zeta 1 | -0.54 |
| ULBP1 | UL16 binding protein 1 | -0.54 |
| FAT2 | FAT atypical cadherin 2 | -0.53 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.52 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.5 |
| SERINC1 | serine incorporator 1 | -0.5 |
| DDX52 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 | -0.49 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.49 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | -0.49 |
| AP5S1 | adaptor-related protein complex 5, sigma 1 subunit | -0.48 |
| SOCS2 | suppressor of cytokine signaling 2 | -0.47 |
| ZNF696 | zinc finger protein 696 | -0.47 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | -0.47 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | -0.46 |
| SFR1 | SWI5-dependent recombination repair 1 | -0.46 |
| GLT8D1 | glycosyltransferase 8 domain containing 1 | -0.46 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | -0.45 |
| NEB | nebulin | -0.45 |
| ZNF34 | zinc finger protein 34 | -0.45 |
| JAK2 | Janus kinase 2 | -0.45 |
| B2M | beta-2-microglobulin | -0.45 |
| CKM | creatine kinase, muscle | -0.45 |
| ATP8B3 | ATPase, aminophospholipid transporter, class I, type 8B, member 3 | -0.44 |
| CCDC158 | coiled-coil domain containing 158 | -0.44 |
| BCORL1 | BCL6 corepressor-like 1 | -0.44 |
| CEP44 | centrosomal protein 44kDa | -0.44 |
| EREG | epiregulin | -0.43 |
| HBA1 | hemoglobin, alpha 1 | -0.43 |
| FAM53B | family with sequence similarity 53, member B | -0.43 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.43 |
| POLH | polymerase (DNA directed), eta | -0.43 |
| ZNF451 | zinc finger protein 451 | -0.42 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | -0.4 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | -0.4 |
| ABHD5 | abhydrolase domain containing 5 | -0.4 |
| VWA3B | von Willebrand factor A domain containing 3B | -0.4 |
| SDC4 | syndecan 4 | -0.4 |
| TSPAN31 | tetraspanin 31 | -0.4 |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | -0.39 |
| MRPL33 | mitochondrial ribosomal protein L33 | -0.38 |
| RBP7 | retinol binding protein 7, cellular | -0.38 |
| C6ORF47 | chromosome 6 open reading frame 47 | -0.37 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 | -0.37 |
| AUNIP | aurora kinase A and ninein interacting protein | -0.37 |
| TGOLN2 | trans-golgi network protein 2 | -0.37 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.36 |
| RGN | regucalcin | -0.36 |
| FAM189B | family with sequence similarity 189, member B | -0.36 |
| FAM210B | family with sequence similarity 210, member B | -0.36 |
| HSPA8 | heat shock 70kDa protein 8 | -0.36 |
| ZNF711 | zinc finger protein 711 | -0.35 |
| TSPAN14 | tetraspanin 14 | -0.35 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | -0.35 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | -0.35 |
| ALKBH1 | alkB, alkylation repair homolog 1 (E. coli) | -0.34 |
| TTYH3 | tweety family member 3 | -0.34 |
| SLC35C1 | solute carrier family 35 (GDP-fucose transporter), member C1 | -0.34 |
| CCNC | cyclin C | -0.34 |
| CAV2 | caveolin 2 | -0.34 |
| CETN1 | centrin, EF-hand protein, 1 | -0.34 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.34 |
| TSC22D2 | TSC22 domain family, member 2 | -0.33 |
| TOP1MT | topoisomerase (DNA) I, mitochondrial | -0.33 |
| DNAH1 | dynein, axonemal, heavy chain 1 | -0.33 |
| PML | promyelocytic leukemia | -0.33 |
| TSPAN9 | tetraspanin 9 | -0.33 |
| UNC13D | unc-13 homolog D (C. elegans) | -0.33 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.33 |
| ZNF689 | zinc finger protein 689 | -0.32 |
| CBLC | Cbl proto-oncogene C, E3 ubiquitin protein ligase | -0.32 |
| GNPNAT1 | glucosamine-phosphate N-acetyltransferase 1 | -0.32 |
| PRG4 | proteoglycan 4 | -0.32 |
| CERS6 | ceramide synthase 6 | -0.32 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.32 |
| C8ORF37 | chromosome 8 open reading frame 37 | -0.32 |
| SLC35F2 | solute carrier family 35, member F2 | -0.31 |
