Pasireotide (acetate)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Pasireotide (acetate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.171912
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.108596
TPM3 tropomyosin 3 0.0974503
DST dystonin 0.0970616
ASPH aspartate beta-hydroxylase 0.0953501
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0940571
CENPF centromere protein F, 350/400kDa 0.0805706
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0782253
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0738881
MAP1B microtubule-associated protein 1B 0.0732159
CDH13 cadherin 13 0.0703864
HDAC9 histone deacetylase 9 0.0687696
BHLHE40 basic helix-loop-helix family, member e40 0.0653087
TRIO trio Rho guanine nucleotide exchange factor 0.0647281
AHNAK AHNAK nucleoprotein 0.064223
GOLGA4 golgin A4 0.0635943
ANKRD11 ankyrin repeat domain 11 0.0633683
RPS6 ribosomal protein S6 0.0606982
MYH9 myosin, heavy chain 9, non-muscle 0.0605158
GOLGB1 golgin B1 0.0602584
DSPP dentin sialophosphoprotein 0.0559289
VIM vimentin 0.0548057
PBX3 pre-B-cell leukemia homeobox 3 0.0541157
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0536443
MACF1 microtubule-actin crosslinking factor 1 0.0533872
CALR calreticulin 0.0528263
MKI67 marker of proliferation Ki-67 0.0526561
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0518858
MSN moesin 0.0508638
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0480496
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0479056
COL4A1 collagen, type IV, alpha 1 0.0470379
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0467502
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0460694
PRRC2C proline-rich coiled-coil 2C 0.0456663
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0452146
SON SON DNA binding protein 0.045117
ADAM9 ADAM metallopeptidase domain 9 0.0442709
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0423624
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0414981
RRBP1 ribosome binding protein 1 0.0412025
MT2A metallothionein 2A 0.0408422
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0402431
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0398253
SMC4 structural maintenance of chromosomes 4 0.0390008
PLAT plasminogen activator, tissue 0.0389973
EZR ezrin 0.0389205
NFE2L1 nuclear factor, erythroid 2-like 1 0.0387605
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0385552
MCL1 myeloid cell leukemia 1 0.0384624
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0382509
PKM pyruvate kinase, muscle 0.0380503
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0375984
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.037157
RND3 Rho family GTPase 3 0.0370962
BCL2L1 BCL2-like 1 0.0367242
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0366254
ALCAM activated leukocyte cell adhesion molecule 0.0366031
FN1 fibronectin 1 0.036465
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0363153
DOCK5 dedicator of cytokinesis 5 0.036311
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0358363
YBX1 Y box binding protein 1 0.0350775
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0344711
B2M beta-2-microglobulin 0.032822
NCOR2 nuclear receptor corepressor 2 0.0327922
TIMP2 TIMP metallopeptidase inhibitor 2 0.0325586
SFTPA2 surfactant protein A2 0.0321214
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0320475
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0312943
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0305801
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.030196
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0300698
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0300623
ERBIN erbb2 interacting protein 0.0299555
EGFR epidermal growth factor receptor 0.0294916
COL5A1 collagen, type V, alpha 1 0.0294177
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0292343
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0288615
RRM2 ribonucleotide reductase M2 0.0287424
KIF5B kinesin family member 5B 0.0284688
ITPRID2 ITPR interacting domain containing 2 0.0283447
PFN1 profilin 1 0.0283425
TMSB10 thymosin beta 10 0.0280822
MT1X metallothionein 1X 0.028056
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.027706
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0276082
TLE4 transducin-like enhancer of split 4 0.0275045
GARS1 glycyl-tRNA synthetase 1 0.0274688
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.027422
PEA15 phosphoprotein enriched in astrocytes 15 0.027237
TMF1 TATA element modulatory factor 1 0.0272115
PDLIM5 PDZ and LIM domain 5 0.0272097
VEGFC vascular endothelial growth factor C 0.0270312
JUN jun proto-oncogene 0.0270203
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.026975
VCL vinculin 0.0267516
POTEF POTE ankyrin domain family, member F 0.0266994
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.026224
BRD2 bromodomain containing 2 0.0262014

decreased expression

Symbol Name Standardized Value
LOX lysyl oxidase -0.155953
FBN1 fibrillin 1 -0.150488
THBS2 thrombospondin 2 -0.130943
DLG1 discs, large homolog 1 (Drosophila) -0.117126
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0905786
LOXL2 lysyl oxidase-like 2 -0.08832
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0876244
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0844005
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0780742
COL1A2 collagen, type I, alpha 2 -0.0756731
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0756051
FNDC3B fibronectin type III domain containing 3B -0.0718902
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0644841
GPC6 glypican 6 -0.0596879
COL3A1 collagen, type III, alpha 1 -0.056793
STC1 stanniocalcin 1 -0.0521958
IGFBP3 insulin-like growth factor binding protein 3 -0.0466268
S100A6 S100 calcium binding protein A6 -0.044766
ABI3BP ABI family, member 3 (NESH) binding protein -0.0441071
SBF2 SET binding factor 2 -0.0441043
ZBTB20 zinc finger and BTB domain containing 20 -0.0440769
AUTS2 autism susceptibility candidate 2 -0.0437679
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0433556
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0427527
SUCNR1 succinate receptor 1 -0.0423756
COL8A1 collagen, type VIII, alpha 1 -0.0423212
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0418017
DPYSL3 dihydropyrimidinase-like 3 -0.0416709
ELL2 elongation factor, RNA polymerase II, 2 -0.0400989
TMOD1 tropomodulin 1 -0.0367313
SOD2 superoxide dismutase 2, mitochondrial -0.0364228
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0351109
PSD3 pleckstrin and Sec7 domain containing 3 -0.0341658
SLC22A23 solute carrier family 22, member 23 -0.0338523
SP3 Sp3 transcription factor -0.0337218
CTSB cathepsin B -0.0334381
SQSTM1 sequestosome 1 -0.0331055
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0326911
PGK1 phosphoglycerate kinase 1 -0.031232
ATP13A3 ATPase type 13A3 -0.0310113
COL5A2 collagen, type V, alpha 2 -0.0305397
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0304241
LDHA lactate dehydrogenase A -0.0300886
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0299731
ARL15 ADP-ribosylation factor-like 15 -0.029724
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0295854
RPS24 ribosomal protein S24 -0.0291796
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0287286
MTSS1 metastasis suppressor 1 -0.0284473
HLA-E major histocompatibility complex, class I, E -0.0283776
VDAC1 voltage-dependent anion channel 1 -0.0279479
TRAM2 translocation associated membrane protein 2 -0.0271721
SLC38A1 solute carrier family 38, member 1 -0.0265459
KDM3A lysine (K)-specific demethylase 3A -0.0261645
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0259877
HIP1 huntingtin interacting protein 1 -0.0259658
ANKRD10 ankyrin repeat domain 10 -0.0259075
BACE2 beta-site APP-cleaving enzyme 2 -0.0256398
SSBP2 single-stranded DNA binding protein 2 -0.02544
ARL4C ADP-ribosylation factor-like 4C -0.0251441
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0246886
UBC ubiquitin C -0.0241763
FTH1 ferritin, heavy polypeptide 1 -0.0240818
TRIM56 tripartite motif containing 56 -0.0235567
ARF1 ADP-ribosylation factor 1 -0.0234469
WTAP Wilms tumor 1 associated protein -0.0231097
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0228774
KIFAP3 kinesin-associated protein 3 -0.0221644
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0221
EPAS1 endothelial PAS domain protein 1 -0.0220328
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0218657
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0214243
MPZL1 myelin protein zero-like 1 -0.0213796
S100A4 S100 calcium binding protein A4 -0.0209979
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0209867
AFF3 AF4/FMR2 family, member 3 -0.0206533
NAMPT nicotinamide phosphoribosyltransferase -0.0204108
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0203445
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0202596
ABI1 abl-interactor 1 -0.020236
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0200435
LRRC49 leucine rich repeat containing 49 -0.0199881
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -0.0198025
HOXD10 homeobox D10 -0.0197412
USP34 ubiquitin specific peptidase 34 -0.0196923
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0195625
FAM114A1 family with sequence similarity 114, member A1 -0.0191667
EIF1 eukaryotic translation initiation factor 1 -0.0191131
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0189541
DENND5A DENN/MADD domain containing 5A -0.0187855
SH3BP2 SH3-domain binding protein 2 -0.0186018
AFAP1 actin filament associated protein 1 -0.0185753
GNS glucosamine (N-acetyl)-6-sulfatase -0.0183854
SOX9 SRY (sex determining region Y)-box 9 -0.018338
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -0.0183302
FRMD5 FERM domain containing 5 -0.0183295
CFLAR CASP8 and FADD-like apoptosis regulator -0.0182336
LOC112694756 uncharaterized LOC112694756 -0.0181673
UBE2O ubiquitin-conjugating enzyme E2O -0.0180414
NPEPPS aminopeptidase puromycin sensitive -0.017951