Pasireotide (acetate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.109694
DST dystonin 0.083394
YBX1 Y box binding protein 1 0.068271
RPS12 ribosomal protein S12 0.0668849
YBX3 Y box binding protein 3 0.066801
AREG amphiregulin 0.0660229
CENPF centromere protein F, 350/400kDa 0.0647619
MARCHF4 membrane associated ring-CH-type finger 4 0.0640503
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0626689
RPS19 ribosomal protein S19 0.0590551
ANKRD12 ankyrin repeat domain 12 0.0567345
TMSB10 thymosin beta 10 0.0541417
TPM3 tropomyosin 3 0.0533851
EEF1G eukaryotic translation elongation factor 1 gamma 0.0486065
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0475069
RPS2 ribosomal protein S2 0.0469517
MKI67 marker of proliferation Ki-67 0.0463594
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0462541
RPS8 ribosomal protein S8 0.045981
RPL37A ribosomal protein L37a 0.0456348
RPL3 ribosomal protein L3 0.0455476
TPI1 triosephosphate isomerase 1 0.0441005
RTN4 reticulon 4 0.0439025
PCM1 pericentriolar material 1 0.0437536
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0431739
RPLP2 ribosomal protein, large, P2 0.0411247
ZNF638 zinc finger protein 638 0.0408585
SFPQ splicing factor proline/glutamine-rich 0.0398198
PRKCI protein kinase C, iota 0.0398033
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.039128
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0386744
AKAP12 A kinase (PRKA) anchor protein 12 0.038658
CHD1 chromodomain helicase DNA binding protein 1 0.0385341
PRRC2C proline-rich coiled-coil 2C 0.0381128
RPS21 ribosomal protein S21 0.0371232
TRIO trio Rho guanine nucleotide exchange factor 0.0366363
CNRIP1 cannabinoid receptor interacting protein 1 0.0362631
TENM3 teneurin transmembrane protein 3 0.0359
RPL8 ribosomal protein L8 0.0353042
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0347568
CCDC88A coiled-coil domain containing 88A 0.0343989
RPS3 ribosomal protein S3 0.0341165
EIF4B eukaryotic translation initiation factor 4B 0.033607
VMP1 vacuole membrane protein 1 0.0333882
RPL36 ribosomal protein L36 0.0333577
KLC1 kinesin light chain 1 0.0331928
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0330872
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0327415
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0327191
EZR ezrin 0.032495
ATP11A ATPase, class VI, type 11A 0.0324524
RPL12 ribosomal protein L12 0.0324163
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0323861
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0323749
SON SON DNA binding protein 0.0316026
CEP70 centrosomal protein 70kDa 0.0310403
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0308676
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0306181
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0304796
ZBTB20 zinc finger and BTB domain containing 20 0.0301672
FTL ferritin, light polypeptide 0.0300524
RSF1 remodeling and spacing factor 1 0.0300133
PFN1 profilin 1 0.0299489
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0299351
OGA O-GlcNAcase 0.0298804
GATAD2B GATA zinc finger domain containing 2B 0.029799
BRD2 bromodomain containing 2 0.0297458
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0295727
SFTPA2 surfactant protein A2 0.0293232
MCL1 myeloid cell leukemia 1 0.0292372
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0289321
SRRM1 serine/arginine repetitive matrix 1 0.0287286
RPL19 ribosomal protein L19 0.0286097
NIPBL Nipped-B homolog (Drosophila) 0.0283333
RIMKLB ribosomal modification protein rimK-like family member B 0.0281787
APLP2 amyloid beta (A4) precursor-like protein 2 0.0281751
TTC3 tetratricopeptide repeat domain 3 0.0278913
FXR1 fragile X mental retardation, autosomal homolog 1 0.0277327
ERBIN erbb2 interacting protein 0.0275753
GOLGA4 golgin A4 0.0275542
BCLAF1 BCL2-associated transcription factor 1 0.0275064
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0271819
RPS27A ribosomal protein S27a 0.0271432
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.027088
TPX2 TPX2, microtubule-associated 0.026988
CKAP5 cytoskeleton associated protein 5 0.026671
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0265289
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0264508
MYH9 myosin, heavy chain 9, non-muscle 0.0263008
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0260303
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0259183
DOCK5 dedicator of cytokinesis 5 0.0258709
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0258632
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0257684
RPS23 ribosomal protein S23 0.0255509
CENPE centromere protein E, 312kDa 0.0254259
FBXO11 F-box protein 11 0.0252417
MED13L mediator complex subunit 13-like 0.0251444
LRP6 low density lipoprotein receptor-related protein 6 0.0249904
ADAM17 ADAM metallopeptidase domain 17 0.0248052

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.131723
PDE4D phosphodiesterase 4D, cAMP-specific -0.108043
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0931876
HMGA2 high mobility group AT-hook 2 -0.083954
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0826395
ACTG1 actin gamma 1 -0.0787524
NHSL1 NHS-like 1 -0.0786479
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0780145
EHBP1 EH domain binding protein 1 -0.0726045
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0693285
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0637244
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0603913
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.058145
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0577534
RAB7A RAB7A, member RAS oncogene family -0.0572493
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0567815
KPNB1 karyopherin (importin) beta 1 -0.054599
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0527827
IFIH1 interferon induced with helicase C domain 1 -0.0494898
CLDN1 claudin 1 -0.0483992
VIM vimentin -0.0470508
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.046604
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0433904
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0433049
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0425485
ZNF804A zinc finger protein 804A -0.04078
NABP1 nucleic acid binding protein 1 -0.0406768
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0405357
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0396451
MMP12 matrix metallopeptidase 12 -0.0391528
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0378698
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.037437
R3HDM2 R3H domain containing 2 -0.0358028
CANX calnexin -0.0356075
TMEM123 transmembrane protein 123 -0.035103
EGR1 early growth response 1 -0.0342862
CXADR coxsackie virus and adenovirus receptor -0.0342315
BCHE butyrylcholinesterase -0.0340719
ADGRG6 adhesion G protein-coupled receptor G6 -0.0334377
RPS24 ribosomal protein S24 -0.0329106
TPM4 tropomyosin 4 -0.0319477
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0313317
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0307593
L3MBTL4 l(3)mbt-like 4 (Drosophila) -0.0302499
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0299567
SPDYA speedy/RINGO cell cycle regulator family member A -0.0299545
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0299169
TM4SF1 transmembrane 4 L six family member 1 -0.0295975
ENO1 enolase 1, (alpha) -0.0288359
S100A6 S100 calcium binding protein A6 -0.0287007
RPLP0 ribosomal protein, large, P0 -0.0280558
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0274677
ADIPOR2 adiponectin receptor 2 -0.027269
RIMS2 regulating synaptic membrane exocytosis 2 -0.0270894
LMO7 LIM domain 7 -0.0263607
DTNA dystrobrevin, alpha -0.0263322
RASAL2 RAS protein activator like 2 -0.0263227
MYL12B myosin, light chain 12B, regulatory -0.0251345
CSMD3 CUB and Sushi multiple domains 3 -0.0251319
TUBB tubulin, beta class I -0.0249841
USP34 ubiquitin specific peptidase 34 -0.0245647
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -0.0244023
LDHA lactate dehydrogenase A -0.0243526
TUBA1B tubulin, alpha 1b -0.0242557
VDAC1 voltage-dependent anion channel 1 -0.0242357
FAM110C family with sequence similarity 110, member C -0.0242027
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0238851
PDIA3 protein disulfide isomerase family A, member 3 -0.0236298
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0236048
ARF1 ADP-ribosylation factor 1 -0.0235481
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0234905
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0233986
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.022994
KSR2 kinase suppressor of ras 2 -0.0228003
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.022603
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0224308
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0222492
MACF1 microtubule-actin crosslinking factor 1 -0.0222097
BABAM2 BRISC and BRCA1 A complex member 2 -0.0220918
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0218391
GASK1B golgi associated kinase 1B -0.0216563
SYT1 synaptotagmin I -0.0215728
TYMS thymidylate synthetase -0.0214474
CUX1 cut-like homeobox 1 -0.0214455
CCND1 cyclin D1 -0.0214074
CCDC47 coiled-coil domain containing 47 -0.0213121
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.0207065
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.020268
UBE2B ubiquitin-conjugating enzyme E2B -0.0202613
INTS6 integrator complex subunit 6 -0.0202075
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0201811
SRP72 signal recognition particle 72kDa -0.0199855
BLTP2 bridge-like lipid transfer protein family member 2 -0.0199507
LOC112694756 uncharaterized LOC112694756 -0.0199309
TAS2R14 taste receptor, type 2, member 14 -0.0198387
GLIPR1 GLI pathogenesis-related 1 -0.0197209
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0196682
ZNF217 zinc finger protein 217 -0.0196626
LMAN1 lectin, mannose-binding, 1 -0.0192842
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0191746