Pasireotide (acetate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF608 zinc finger protein 608 0.146544
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.137766
COL5A2 collagen, type V, alpha 2 0.127285
CENPF centromere protein F, 350/400kDa 0.121816
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0974839
MKI67 marker of proliferation Ki-67 0.0718438
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0692792
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.064473
RIGI RNA sensor RIG-I 0.0607537
JMJD1C jumonji domain containing 1C 0.0598265
VCL vinculin 0.0595114
RPS2 ribosomal protein S2 0.0593913
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0578269
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0571013
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0554535
RPS6 ribosomal protein S6 0.0536368
DST dystonin 0.0530183
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.052253
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0521189
HSPA8 heat shock 70kDa protein 8 0.0513388
SFPQ splicing factor proline/glutamine-rich 0.0486428
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.048
NALF1 NALCN channel auxiliary factor 1 0.0452979
CCDC88A coiled-coil domain containing 88A 0.0451589
FBXL7 F-box and leucine-rich repeat protein 7 0.0450537
RPS12 ribosomal protein S12 0.0447464
ASPH aspartate beta-hydroxylase 0.0428443
CKAP5 cytoskeleton associated protein 5 0.0427184
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0426905
RPL3 ribosomal protein L3 0.0425603
TPM3 tropomyosin 3 0.0423009
NFIA nuclear factor I/A 0.0422299
CENPE centromere protein E, 312kDa 0.0411684
ZNF638 zinc finger protein 638 0.041118
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0409917
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0388363
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0385891
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0383135
VMP1 vacuole membrane protein 1 0.0380449
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.037771
SRSF4 serine/arginine-rich splicing factor 4 0.0372378
SMC1A structural maintenance of chromosomes 1A 0.0370398
MAGEA4 melanoma antigen family A4 0.0369852
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0369029
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0359571
YBX1 Y box binding protein 1 0.0353815
PHF21A PHD finger protein 21A 0.0343489
BPTF bromodomain PHD finger transcription factor 0.0342189
ATG10 autophagy related 10 0.0337665
WWOX WW domain containing oxidoreductase 0.033565
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.0333056
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0325127
ZC3H12B zinc finger CCCH-type containing 12B 0.0323224
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0319311
EEF1G eukaryotic translation elongation factor 1 gamma 0.0318937
HMGB2 high mobility group box 2 0.0316287
HP1BP3 heterochromatin protein 1, binding protein 3 0.0311579
TBC1D5 TBC1 domain family, member 5 0.0307225
DCDC2 doublecortin domain containing 2 0.0306576
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0304545
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0304212
NRDC nardilysin convertase 0.0298056
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0297332
UBXN4 UBX domain protein 4 0.0297157
CDH18 cadherin 18, type 2 0.0288005
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0284545
TXNRD1 thioredoxin reductase 1 0.0283131
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0283121
IFI6 interferon, alpha-inducible protein 6 0.0282627
RRM2 ribonucleotide reductase M2 0.0282437
WLS wntless Wnt ligand secretion mediator 0.028067
KIF5B kinesin family member 5B 0.0277824
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0276677
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0276262
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0275062
SYAP1 synapse associated protein 1 0.0273732
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0270056
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0268319
TPR translocated promoter region, nuclear basket protein 0.0267997
USP47 ubiquitin specific peptidase 47 0.0262713
SIK3 SIK family kinase 3 0.0261815
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0261709
NFIB nuclear factor I/B 0.0259786
EIF4B eukaryotic translation initiation factor 4B 0.0255887
LRP6 low density lipoprotein receptor-related protein 6 0.0248537
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0248471
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0247977
USP34 ubiquitin specific peptidase 34 0.0247618
BCLAF1 BCL2-associated transcription factor 1 0.0246286
TRIP12 thyroid hormone receptor interactor 12 0.0246257
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.024594
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0245149
ZFHX4 zinc finger homeobox 4 0.0244833
REST RE1-silencing transcription factor 0.0244161
GIGYF2 GRB10 interacting GYF protein 2 0.0242133
NBEA neurobeachin 0.0239958
CEP112 centrosomal protein 112kDa 0.0239634
PNN pinin, desmosome associated protein 0.0239242
OGA O-GlcNAcase 0.0238562
CARD18 caspase recruitment domain family, member 18 0.0235732

decreased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.224058
NPAS3 neuronal PAS domain protein 3 -0.182303
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140318
RAD51B RAD51 paralog B -0.114395
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.112085
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.104346
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0835397
EFNA5 ephrin-A5 -0.0771032
ACTG1 actin gamma 1 -0.0667628
GRID2 glutamate receptor, ionotropic, delta 2 -0.0630309
RPS24 ribosomal protein S24 -0.0626324
SOX4 SRY (sex determining region Y)-box 4 -0.0567767
CADM2 cell adhesion molecule 2 -0.0537899
EMP1 epithelial membrane protein 1 -0.0513065
PTMA prothymosin, alpha -0.0498728
TMSB10 thymosin beta 10 -0.0478913
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0474236
WDR45B WD repeat domain 45B -0.0461464
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0457602
SLF1 SMC5-SMC6 complex localization factor 1 -0.0450599
RAP1B RAP1B, member of RAS oncogene family -0.0446984
RPS5 ribosomal protein S5 -0.0435261
FMNL2 formin-like 2 -0.0431381
MCTP1 multiple C2 domains, transmembrane 1 -0.0407142
KPNB1 karyopherin (importin) beta 1 -0.0401204
LMAN1 lectin, mannose-binding, 1 -0.0396706
ARB2A ARB2 cotranscriptional regulator A -0.0389723
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0386739
TENM2 teneurin transmembrane protein 2 -0.0386305
NT5C2 5'-nucleotidase, cytosolic II -0.0385734
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0369186
TBC1D32 TBC1 domain family, member 32 -0.0363053
RPS11 ribosomal protein S11 -0.0356696
RPL35A ribosomal protein L35a -0.0348805
TTC3 tetratricopeptide repeat domain 3 -0.0347407
FOXO3 forkhead box O3 -0.0342916
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0342896
TRIO trio Rho guanine nucleotide exchange factor -0.0335007
PGK1 phosphoglycerate kinase 1 -0.0331044
RPLP1 ribosomal protein, large, P1 -0.0329005
RPS13 ribosomal protein S13 -0.0328132
IARS1 isoleucyl-tRNA synthetase 1 -0.0324322
RPL27A ribosomal protein L27a -0.0323061
VDAC1 voltage-dependent anion channel 1 -0.0321031
RPLP2 ribosomal protein, large, P2 -0.0314803
HILPDA hypoxia inducible lipid droplet-associated -0.0314711
ARF1 ADP-ribosylation factor 1 -0.0311633
MAP4 microtubule-associated protein 4 -0.0304565
HMGA1 high mobility group AT-hook 1 -0.0300542
PCDH11X protocadherin 11 X-linked -0.02942
GARS1 glycyl-tRNA synthetase 1 -0.0293909
ACACA acetyl-CoA carboxylase alpha -0.0292539
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.028992
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0289505
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0287478
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0286876
GAB2 GRB2-associated binding protein 2 -0.0280767
ATP9A ATPase, class II, type 9A -0.0279028
RPL11 ribosomal protein L11 -0.0276262
ZFP64 ZFP64 zinc finger protein -0.0272131
FASN fatty acid synthase -0.0269376
KDM3A lysine (K)-specific demethylase 3A -0.0269042
CALU calumenin -0.0264513
ZNF544 zinc finger protein 544 -0.0261101
CANX calnexin -0.0260183
RPL23 ribosomal protein L23 -0.0259624
TMEM123 transmembrane protein 123 -0.0258225
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0257055
BLTP2 bridge-like lipid transfer protein family member 2 -0.0248315
CCNY cyclin Y -0.0245066
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0243767
RPS25 ribosomal protein S25 -0.024318
SHROOM3 shroom family member 3 -0.0240566
LDHA lactate dehydrogenase A -0.0240153
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0238789
TPT1 tumor protein, translationally-controlled 1 -0.0237062
RPL31 ribosomal protein L31 -0.0236903
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.023283
SOX2 SRY (sex determining region Y)-box 2 -0.0230884
FOXK2 forkhead box K2 -0.0230596
TUBB tubulin, beta class I -0.0230009
PEG10 paternally expressed 10 -0.022828
HMGB1 high mobility group box 1 -0.0226872
TENM3 teneurin transmembrane protein 3 -0.0223292
ZNF217 zinc finger protein 217 -0.0222802
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0219633
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.021882
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.021469
CAVIN1 caveolae associated protein 1 -0.0214132
RACK1 receptor for activated C kinase 1 -0.0213864
EIF1 eukaryotic translation initiation factor 1 -0.0212993
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0209717
RPS21 ribosomal protein S21 -0.0209367
FBL fibrillarin -0.0208002
RPL15 ribosomal protein L15 -0.0207627
HHIP hedgehog interacting protein -0.0206807
RPS23 ribosomal protein S23 -0.0206023
LPIN2 lipin 2 -0.0204596
ATP5F1B ATP synthase F1 subunit beta -0.0202651
CELF2 CUGBP, Elav-like family member 2 -0.0202081