Pasireotide (acetate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.164098
FN1 fibronectin 1 0.153033
IGFBP5 insulin-like growth factor binding protein 5 0.140191
SFTPA2 surfactant protein A2 0.11709
VGF VGF nerve growth factor inducible 0.106667
ASPH aspartate beta-hydroxylase 0.0991941
FMN1 formin 1 0.0883237
DST dystonin 0.0839353
CENPF centromere protein F, 350/400kDa 0.0696752
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.069259
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0667271
TM4SF1 transmembrane 4 L six family member 1 0.066457
TIMP3 TIMP metallopeptidase inhibitor 3 0.065451
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0648267
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0579915
TPR translocated promoter region, nuclear basket protein 0.0551118
AHNAK AHNAK nucleoprotein 0.0526479
RRBP1 ribosome binding protein 1 0.0520699
GOLGB1 golgin B1 0.0505413
MYH9 myosin, heavy chain 9, non-muscle 0.0497544
VCL vinculin 0.0493936
NDRG1 N-myc downstream regulated 1 0.0488766
TPT1 tumor protein, translationally-controlled 1 0.0481515
TSC22D1 TSC22 domain family, member 1 0.04708
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0470437
FMNL2 formin-like 2 0.0463055
PTMA prothymosin, alpha 0.0462121
HLA-B major histocompatibility complex, class I, B 0.0461549
RPS8 ribosomal protein S8 0.0433227
NFE2L1 nuclear factor, erythroid 2-like 1 0.0432524
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0426729
TLE4 transducin-like enhancer of split 4 0.0407535
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0404955
SDC2 syndecan 2 0.0403108
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0402394
GOLGA4 golgin A4 0.0400008
RPS6 ribosomal protein S6 0.0399513
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0396786
PTCHD4 patched domain containing 4 0.0392136
APLP2 amyloid beta (A4) precursor-like protein 2 0.0383022
MKI67 marker of proliferation Ki-67 0.0376767
PRRC2C proline-rich coiled-coil 2C 0.037656
AKAP9 A kinase (PRKA) anchor protein 9 0.0376149
IFI6 interferon, alpha-inducible protein 6 0.0369562
BHLHE40 basic helix-loop-helix family, member e40 0.0365867
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0359453
ZSWIM6 zinc finger, SWIM-type containing 6 0.0357228
YBX1 Y box binding protein 1 0.0354643
RPS12 ribosomal protein S12 0.0352248
VEGFA vascular endothelial growth factor A 0.0351039
GPC6 glypican 6 0.0349327
RPL37A ribosomal protein L37a 0.0345939
B2M beta-2-microglobulin 0.0345929
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0336828
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0333598
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0331838
PDLIM5 PDZ and LIM domain 5 0.032189
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0320395
RPS2 ribosomal protein S2 0.0317057
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0314598
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0314483
NPC1 Niemann-Pick disease, type C1 0.0313112
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0310637
ANO6 anoctamin 6 0.0306624
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0303588
PRELID2 PRELI domain containing 2 0.030215
MCL1 myeloid cell leukemia 1 0.0299827
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0298813
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0298601
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0297952
CEMIP2 cell migration inducing hyaluronidase 2 0.0294759
FRMD4A FERM domain containing 4A 0.0294593
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.028911
RPL11 ribosomal protein L11 0.0288452
AHCYL2 adenosylhomocysteinase-like 2 0.0284188
RBBP6 retinoblastoma binding protein 6 0.0279458
WWTR1 WW domain containing transcription regulator 1 0.0279456
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0279117
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0278577
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.027831
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.027812
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0277008
OGA O-GlcNAcase 0.0276125
PHF3 PHD finger protein 3 0.0274071
LGALS3 lectin, galactoside-binding, soluble, 3 0.0273221
TMF1 TATA element modulatory factor 1 0.027219
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0271419
NAP1L1 nucleosome assembly protein 1-like 1 0.0270665
RPL3 ribosomal protein L3 0.0269431
MACF1 microtubule-actin crosslinking factor 1 0.026345
TPM3 tropomyosin 3 0.0260113
ARHGAP5 Rho GTPase activating protein 5 0.0259963
ZC3H11A zinc finger CCCH-type containing 11A 0.0259421
VMP1 vacuole membrane protein 1 0.0258947
IFRD1 interferon-related developmental regulator 1 0.0258743
SFPQ splicing factor proline/glutamine-rich 0.0249682
ZYX zyxin 0.0248157
SLK STE20-like kinase 0.0244158
CEP350 centrosomal protein 350kDa 0.0243917
CTNND1 catenin (cadherin-associated protein), delta 1 0.0242841

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.220958
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.146022
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.136115
NLGN1 neuroligin 1 -0.118652
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.111092
DCT dopachrome tautomerase -0.0626757
CHSY1 chondroitin sulfate synthase 1 -0.0591635
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0547967
NPAS2 neuronal PAS domain protein 2 -0.05442
LOC112694756 uncharaterized LOC112694756 -0.0536541
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0531882
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0502782
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0498006
RNF24 ring finger protein 24 -0.0496679
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0486532
HILPDA hypoxia inducible lipid droplet-associated -0.0467084
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0440676
SOX5 SRY (sex determining region Y)-box 5 -0.0427149
CDK14 cyclin-dependent kinase 14 -0.0420277
RFX7 regulatory factor X, 7 -0.0416582
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0409139
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0398814
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0398522
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0394776
GSK3B glycogen synthase kinase 3 beta -0.0385841
FOSL1 FOS-like antigen 1 -0.0383521
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0376924
NBAS neuroblastoma amplified sequence -0.0376434
POM121C POM121 transmembrane nucleoporin C -0.0375885
ICAM1 intercellular adhesion molecule 1 -0.0372965
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0365305
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0358443
VDAC1 voltage-dependent anion channel 1 -0.035034
PTPRD protein tyrosine phosphatase, receptor type, D -0.0349033
NHSL1 NHS-like 1 -0.0348055
TAGLN2 transgelin 2 -0.034191
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0331739
TMEM123 transmembrane protein 123 -0.0326749
PDIA3 protein disulfide isomerase family A, member 3 -0.032477
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0324769
FAM117B family with sequence similarity 117, member B -0.0324666
NAMPT nicotinamide phosphoribosyltransferase -0.0324539
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.031738
HMCN1 hemicentin 1 -0.0313531
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0309914
SREBF2 sterol regulatory element binding transcription factor 2 -0.0306845
WDR45B WD repeat domain 45B -0.0306499
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0305315
GDF15 growth differentiation factor 15 -0.030266
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0299632
IFITM1 interferon induced transmembrane protein 1 -0.0299353
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0297903
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0296741
NUP58 nucleoporin 58 -0.0296102
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.029007
OXR1 oxidation resistance 1 -0.0282404
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0277375
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0276763
MIDEAS mitotic deacetylase associated SANT domain protein -0.0275214
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.027507
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0271867
SSH1 slingshot protein phosphatase 1 -0.0271567
ZNF292 zinc finger protein 292 -0.0271241
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0261701
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0261464
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0259701
ESYT2 extended synaptotagmin-like protein 2 -0.0259037
MACROD2 MACRO domain containing 2 -0.025527
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0248317
SCFD2 sec1 family domain containing 2 -0.024739
CDC73 cell division cycle 73 -0.0244033
RHEB Ras homolog enriched in brain -0.0243224
KDM2A lysine (K)-specific demethylase 2A -0.0243188
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0242951
PCDH7 protocadherin 7 -0.0239574
ZNF654 zinc finger protein 654 -0.0236862
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0236284
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.0235546
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0232592
PTK2 protein tyrosine kinase 2 -0.022952
FOXJ3 forkhead box J3 -0.0228294
MEIS2 Meis homeobox 2 -0.0228021
INSIG1 insulin induced gene 1 -0.0225334
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -0.0223863
NRCAM neuronal cell adhesion molecule -0.0223459
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0221101
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0217496
FBXO17 F-box protein 17 -0.0212789
ZNF704 zinc finger protein 704 -0.0205967
FHIT fragile histidine triad -0.0205574
FAM162A family with sequence similarity 162, member A -0.020519
ZNF638 zinc finger protein 638 -0.020444
MRTFA myocardin related transcription factor A -0.0203687
BIRC6 baculoviral IAP repeat containing 6 -0.0203615
MRPS6 mitochondrial ribosomal protein S6 -0.0202672
DPYD dihydropyrimidine dehydrogenase -0.0202083
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0201428
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0200333
TBK1 TANK-binding kinase 1 -0.0200026
AGMO alkylglycerol monooxygenase -0.0197273