Pasireotide (acetate)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPTBN1 spectrin, beta, non-erythrocytic 1 0.135532
AKAP12 A kinase (PRKA) anchor protein 12 0.134709
ASPH aspartate beta-hydroxylase 0.127213
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.12311
MT2A metallothionein 2A 0.122747
AHNAK AHNAK nucleoprotein 0.108082
APLP2 amyloid beta (A4) precursor-like protein 2 0.0993256
MYH9 myosin, heavy chain 9, non-muscle 0.0960656
DST dystonin 0.0851578
RPS6 ribosomal protein S6 0.0837286
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0821609
APP amyloid beta (A4) precursor protein 0.0805071
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0800604
SAMD4A sterile alpha motif domain containing 4A 0.0774195
LAMC2 laminin, gamma 2 0.0760887
SYNE2 spectrin repeat containing, nuclear envelope 2 0.07454
TPM3 tropomyosin 3 0.0715196
MCL1 myeloid cell leukemia 1 0.0673927
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0639386
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0623734
LAMB3 laminin, beta 3 0.0622795
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0608964
DSG2 desmoglein 2 0.0599601
TGM2 transglutaminase 2 0.0592686
DSPP dentin sialophosphoprotein 0.0568881
VEGFA vascular endothelial growth factor A 0.0545355
MACF1 microtubule-actin crosslinking factor 1 0.0544977
AREG amphiregulin 0.0539248
IGFBP3 insulin-like growth factor binding protein 3 0.052761
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0517063
GOLGB1 golgin B1 0.0503483
TXNIP thioredoxin interacting protein 0.0500903
LAMA4 laminin, alpha 4 0.0498465
ARHGAP5 Rho GTPase activating protein 5 0.0498022
SFTPA2 surfactant protein A2 0.0484262
ADAM9 ADAM metallopeptidase domain 9 0.0482042
YBX1 Y box binding protein 1 0.0476392
TNIP1 TNFAIP3 interacting protein 1 0.0473387
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0451492
KTN1 kinectin 1 (kinesin receptor) 0.044471
EZR ezrin 0.0431009
OPTN optineurin 0.0429406
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0394804
PLAU plasminogen activator, urokinase 0.0394242
BCL2L1 BCL2-like 1 0.0387636
EEF1G eukaryotic translation elongation factor 1 gamma 0.0387147
SLK STE20-like kinase 0.0385
RPL3 ribosomal protein L3 0.0383931
PHF3 PHD finger protein 3 0.0381686
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0375298
FAM3C family with sequence similarity 3, member C 0.0375266
SPATS2L spermatogenesis associated, serine-rich 2-like 0.036713
ITPRID2 ITPR interacting domain containing 2 0.0366659
RPL19 ribosomal protein L19 0.0366252
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0352266
RPS2 ribosomal protein S2 0.0350726
MKI67 marker of proliferation Ki-67 0.0349938
NDRG1 N-myc downstream regulated 1 0.0349286
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.034697
BCAR3 breast cancer anti-estrogen resistance 3 0.0341118
HSPA8 heat shock 70kDa protein 8 0.0340634
RPS12 ribosomal protein S12 0.0321988
PDIA6 protein disulfide isomerase family A, member 6 0.0320371
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0320165
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0317188
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0314582
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0312329
SVIL supervillin 0.0311131
B2M beta-2-microglobulin 0.0310729
RTN4 reticulon 4 0.0306297
MX1 MX dynamin-like GTPase 1 0.0300494
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0298998
CTNND1 catenin (cadherin-associated protein), delta 1 0.0295225
WWTR1 WW domain containing transcription regulator 1 0.0294661
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.029186
PRRC2C proline-rich coiled-coil 2C 0.0285877
UBC ubiquitin C 0.0284018
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0282235
MCFD2 multiple coagulation factor deficiency 2 0.0281229
NFE2L1 nuclear factor, erythroid 2-like 1 0.0280203
OGA O-GlcNAcase 0.0277991
SLTM SAFB-like, transcription modulator 0.0277762
MSN moesin 0.0275911
VMP1 vacuole membrane protein 1 0.0274908
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0270765
PDZD8 PDZ domain containing 8 0.0269039
PLEC plectin 0.0267404
RAB8B RAB8B, member RAS oncogene family 0.0267184
AKAP9 A kinase (PRKA) anchor protein 9 0.0263488
GOLGA4 golgin A4 0.0263387
RPS8 ribosomal protein S8 0.0257382
RAI14 retinoic acid induced 14 0.0253958
MYO5B myosin VB 0.0253466
LAMB1 laminin, beta 1 0.0253014
TMF1 TATA element modulatory factor 1 0.025133
AHNAK2 AHNAK nucleoprotein 2 0.0250368
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0248985
SH3KBP1 SH3-domain kinase binding protein 1 0.0248933
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0247319
CD2AP CD2-associated protein 0.0247057

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.252624
MMP7 matrix metallopeptidase 7 -0.231693
CP ceruloplasmin (ferroxidase) -0.202087
PTMA prothymosin, alpha -0.13355
TMSB10 thymosin beta 10 -0.117915
S100A6 S100 calcium binding protein A6 -0.10417
ACTG1 actin gamma 1 -0.100565
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0967645
F3 coagulation factor III (thromboplastin, tissue factor) -0.0899247
SLC38A1 solute carrier family 38, member 1 -0.0737108
HLA-B major histocompatibility complex, class I, B -0.0735572
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0673342
TPT1 tumor protein, translationally-controlled 1 -0.0603239
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0601068
POTEF POTE ankyrin domain family, member F -0.0576673
RPS24 ribosomal protein S24 -0.0556226
PLAT plasminogen activator, tissue -0.0543443
ARHGAP26 Rho GTPase activating protein 26 -0.053213
IFI27 interferon, alpha-inducible protein 27 -0.0521772
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0509458
HMGA1 high mobility group AT-hook 1 -0.049564
RPL35A ribosomal protein L35a -0.0483589
TMSB4X thymosin beta 4, X-linked -0.0458157
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0447557
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.04365
LMNA lamin A/C -0.0430175
IER3 immediate early response 3 -0.0416233
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0411219
LY6E lymphocyte antigen 6 complex, locus E -0.0373894
IFITM1 interferon induced transmembrane protein 1 -0.0360569
MUC4 mucin 4, cell surface associated -0.0359367
TMEM165 transmembrane protein 165 -0.0358757
ZMYND8 zinc finger, MYND-type containing 8 -0.0355917
S100A11 S100 calcium binding protein A11 -0.0354956
VDAC1 voltage-dependent anion channel 1 -0.0354556
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0342011
JUP junction plakoglobin -0.033945
FTH1 ferritin, heavy polypeptide 1 -0.0338622
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0338553
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0337976
KRT19 keratin 19, type I -0.0328284
RAB7A RAB7A, member RAS oncogene family -0.0323958
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.032109
PGK1 phosphoglycerate kinase 1 -0.0319247
ARHGAP32 Rho GTPase activating protein 32 -0.0317952
GRB10 growth factor receptor-bound protein 10 -0.0315765
GNAS GNAS complex locus -0.0314949
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.030537
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.03028
KPNB1 karyopherin (importin) beta 1 -0.0296639
MRPS6 mitochondrial ribosomal protein S6 -0.0296197
TAGLN2 transgelin 2 -0.0289833
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0284633
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0283647
EGR1 early growth response 1 -0.0280573
NCKAP5 NCK-associated protein 5 -0.0279712
S100P S100 calcium binding protein P -0.0278802
LGALS3 lectin, galactoside-binding, soluble, 3 -0.027411
NT5C2 5'-nucleotidase, cytosolic II -0.0273912
ADAM28 ADAM metallopeptidase domain 28 -0.0272587
EXT1 exostosin glycosyltransferase 1 -0.0271608
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.026995
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0268338
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0268188
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0267822
WARS1 tryptophanyl-tRNA synthetase 1 -0.026769
ANXA2 annexin A2 -0.0267066
GMDS GDP-mannose 4,6-dehydratase -0.0267047
RAB1A RAB1A, member RAS oncogene family -0.0264285
LASP1 LIM and SH3 protein 1 -0.0259187
INSIG1 insulin induced gene 1 -0.0257877
CTSD cathepsin D -0.0257147
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0253608
MX2 MX dynamin-like GTPase 2 -0.0250285
CLINT1 clathrin interactor 1 -0.0250086
TUBB tubulin, beta class I -0.024917
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -0.0248724
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0248618
PDLIM5 PDZ and LIM domain 5 -0.0248582
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0246714
PARD3 par-3 family cell polarity regulator -0.0246227
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0241583
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -0.0238917
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0238588
KLF5 Kruppel-like factor 5 (intestinal) -0.0236547
RPLP1 ribosomal protein, large, P1 -0.0235848
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0233026
ANXA4 annexin A4 -0.0233001
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0232921
PERP PERP, TP53 apoptosis effector -0.0230557
TUBA1B tubulin, alpha 1b -0.023047
SPDYA speedy/RINGO cell cycle regulator family member A -0.022856
TMEM123 transmembrane protein 123 -0.0225758
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0225592
WIPF2 WAS/WASL interacting protein family, member 2 -0.0223652
LDHA lactate dehydrogenase A -0.02232
SESTD1 SEC14 and spectrin domains 1 -0.0221147
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0219581
FDPS farnesyl diphosphate synthase -0.0216627
GABRP gamma-aminobutyric acid (GABA) A receptor, pi -0.0215283