Pasireotide (acetate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.142513
MAP1B microtubule-associated protein 1B 0.10207
RPS6 ribosomal protein S6 0.0738837
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0681077
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0657747
NALF1 NALCN channel auxiliary factor 1 0.062201
PLAT plasminogen activator, tissue 0.0617667
CEMIP cell migration inducing protein, hyaluronan binding 0.0604999
CD36 CD36 molecule (thrombospondin receptor) 0.0591552
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0528328
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0521837
ITPRID2 ITPR interacting domain containing 2 0.0495538
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0477378
MACF1 microtubule-actin crosslinking factor 1 0.0473
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0466088
TRIO trio Rho guanine nucleotide exchange factor 0.0456576
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0454611
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0445603
AKAP9 A kinase (PRKA) anchor protein 9 0.0445523
ASPH aspartate beta-hydroxylase 0.044059
PDE10A phosphodiesterase 10A 0.0426308
TPST1 tyrosylprotein sulfotransferase 1 0.0417607
PCBP2 poly(rC) binding protein 2 0.0416831
MEF2A myocyte enhancer factor 2A 0.0414183
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0408415
SLITRK6 SLIT and NTRK-like family, member 6 0.0406421
EEF1G eukaryotic translation elongation factor 1 gamma 0.0406326
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0405138
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0397949
FAM107B family with sequence similarity 107, member B 0.0390765
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0386198
PTPRK protein tyrosine phosphatase, receptor type, K 0.0369546
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0367562
PLPP1 phospholipid phosphatase 1 0.036279
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0357662
SYT1 synaptotagmin I 0.0348173
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0347414
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0337667
PTPRE protein tyrosine phosphatase, receptor type, E 0.0335774
ARHGAP9 Rho GTPase activating protein 9 0.033229
SDK1 sidekick cell adhesion molecule 1 0.0327495
ANTXR1 anthrax toxin receptor 1 0.0327296
NFE2L1 nuclear factor, erythroid 2-like 1 0.0325938
VMP1 vacuole membrane protein 1 0.0315002
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0312162
DST dystonin 0.0312052
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0306436
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0304182
PCBP3 poly(rC) binding protein 3 0.0296121
RPL3 ribosomal protein L3 0.0285511
LINGO2 leucine rich repeat and Ig domain containing 2 0.0284921
TMF1 TATA element modulatory factor 1 0.0281395
LPIN1 lipin 1 0.027955
VEGFA vascular endothelial growth factor A 0.0278878
COL4A1 collagen, type IV, alpha 1 0.0274663
BCLAF1 BCL2-associated transcription factor 1 0.027323
ANO6 anoctamin 6 0.0272423
ARHGAP24 Rho GTPase activating protein 24 0.0271991
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0270127
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0269481
PCM1 pericentriolar material 1 0.0269302
FNDC3B fibronectin type III domain containing 3B 0.0268947
PTEN phosphatase and tensin homolog 0.0267784
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0266085
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.0264251
NF1 neurofibromin 1 0.0263625
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0262017
HSPA8 heat shock 70kDa protein 8 0.0261375
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0258391
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0257999
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0251831
FAM13A family with sequence similarity 13, member A 0.0248441
MYH9 myosin, heavy chain 9, non-muscle 0.0245172
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0244783
MBNL2 muscleblind-like splicing regulator 2 0.0244384
GAB2 GRB2-associated binding protein 2 0.0244289
B2M beta-2-microglobulin 0.0243581
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0243559
HMBOX1 homeobox containing 1 0.0236067
CLCN3 chloride channel, voltage-sensitive 3 0.0233409
RPS2 ribosomal protein S2 0.0230232
DNMBP dynamin binding protein 0.0230047
KMT2E lysine (K)-specific methyltransferase 2E 0.0229128
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.022835
SRRM2 serine/arginine repetitive matrix 2 0.0224998
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0221985
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0219408
GLI3 GLI family zinc finger 3 0.0219059
RTN4 reticulon 4 0.0218564
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0217969
PKM pyruvate kinase, muscle 0.0217909
KTN1 kinectin 1 (kinesin receptor) 0.0217257
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0215958
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.021478
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0213886
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0213777
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0211236
SOS1 son of sevenless homolog 1 (Drosophila) 0.0210355
ADARB1 adenosine deaminase, RNA-specific, B1 0.020618
TPM3 tropomyosin 3 0.0204928

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.503529
FMN1 formin 1 -0.136516
VCL vinculin -0.0707245
EXT1 exostosin glycosyltransferase 1 -0.0684073
PTMA prothymosin, alpha -0.0659372
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0654801
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0629114
ACTG1 actin gamma 1 -0.0629033
DNAH14 dynein, axonemal, heavy chain 14 -0.0546623
RPS24 ribosomal protein S24 -0.0536337
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0515797
RPL35A ribosomal protein L35a -0.0510318
TPT1 tumor protein, translationally-controlled 1 -0.0466593
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0464701
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0463019
MSI2 musashi RNA-binding protein 2 -0.0449724
VIM vimentin -0.0430599
NRG1 neuregulin 1 -0.0407112
TPM1 tropomyosin 1 (alpha) -0.0403868
NREP neuronal regeneration related protein -0.0397263
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.038114
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0371421
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0365575
PCNX4 pecanex 4 -0.0355777
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0353494
CUX1 cut-like homeobox 1 -0.0350167
CADM2 cell adhesion molecule 2 -0.034294
ZNF124 zinc finger protein 124 -0.0342409
LSAMP limbic system-associated membrane protein -0.0333074
MED13 mediator complex subunit 13 -0.0327448
HIP1 huntingtin interacting protein 1 -0.0327429
RAB7A RAB7A, member RAS oncogene family -0.0326918
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0326092
FKBP10 FK506 binding protein 10, 65 kDa -0.032568
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0321919
SLC39A11 solute carrier family 39, member 11 -0.0319286
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0314165
NAP1L1 nucleosome assembly protein 1-like 1 -0.029978
SCLT1 sodium channel and clathrin linker 1 -0.0295311
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0289791
PCDH9 protocadherin 9 -0.0287676
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0285278
INTS6 integrator complex subunit 6 -0.0283191
CCND1 cyclin D1 -0.0271054
GREM2 gremlin 2, DAN family BMP antagonist -0.0270744
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0269578
FHIT fragile histidine triad -0.0268634
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0267125
GPC5 glypican 5 -0.0266891
ENAH enabled homolog (Drosophila) -0.0265393
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0264628
TMSB10 thymosin beta 10 -0.0257032
KPNB1 karyopherin (importin) beta 1 -0.0256959
KDM3A lysine (K)-specific demethylase 3A -0.0253773
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.025326
TET1 tet methylcytosine dioxygenase 1 -0.0252894
FNDC3A fibronectin type III domain containing 3A -0.0251227
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0250835
NCOA7 nuclear receptor coactivator 7 -0.0241501
UNC5C unc-5 homolog C (C. elegans) -0.0238149
NPR2 natriuretic peptide receptor 2 -0.0237215
COL3A1 collagen, type III, alpha 1 -0.0237092
ACTN4 actinin, alpha 4 -0.0233632
RPL38 ribosomal protein L38 -0.0231461
TAS2R14 taste receptor, type 2, member 14 -0.0231401
TPM4 tropomyosin 4 -0.0230454
CNTN4 contactin 4 -0.0228503
TULP4 tubby like protein 4 -0.0226452
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0225229
AHR aryl hydrocarbon receptor -0.0225057
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0223641
HOMER1 homer scaffolding protein 1 -0.0223575
PCDH11Y protocadherin 11 Y-linked -0.0218695
AEBP2 AE binding protein 2 -0.0216297
TRA2A transformer 2 alpha homolog (Drosophila) -0.0213522
SMYD3 SET and MYND domain containing 3 -0.021286
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0212427
GLI2 GLI family zinc finger 2 -0.0211333
PBX1 pre-B-cell leukemia homeobox 1 -0.0210846
RAP1B RAP1B, member of RAS oncogene family -0.0210604
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0209465
TBC1D16 TBC1 domain family, member 16 -0.020855
ARF1 ADP-ribosylation factor 1 -0.0207772
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0206894
RGS5 regulator of G-protein signaling 5 -0.0205647
LMNA lamin A/C -0.0203253
MYO1E myosin IE -0.0202902
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0202264
PRRC2C proline-rich coiled-coil 2C -0.020067
TFRC transferrin receptor -0.0197996
GNAS GNAS complex locus -0.0197371
ZNF609 zinc finger protein 609 -0.019394
RAD21 RAD21 homolog (S. pombe) -0.0192829
SP100 SP100 nuclear antigen -0.0192747
SQSTM1 sequestosome 1 -0.0190847
MAML2 mastermind-like 2 (Drosophila) -0.0188916
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0188138
SNX14 sorting nexin 14 -0.0186994
MYO9A myosin IXA -0.0186471
PARD3 par-3 family cell polarity regulator -0.0185346