Pasireotide (acetate)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.21723
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0949659
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0891767
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0862771
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0739726
TXNIP thioredoxin interacting protein 0.0691484
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0688008
MYO1E myosin IE 0.0684947
TSC22D1 TSC22 domain family, member 1 0.0675096
DSCAM Down syndrome cell adhesion molecule 0.0663488
B2M beta-2-microglobulin 0.0660646
EZR ezrin 0.0585772
MYH9 myosin, heavy chain 9, non-muscle 0.058375
ARHGAP26 Rho GTPase activating protein 26 0.0578327
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0562402
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.05598
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0545585
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0544132
SHB Src homology 2 domain containing adaptor protein B 0.0537065
MEIS2 Meis homeobox 2 0.050564
EFNB2 ephrin-B2 0.0501327
VMP1 vacuole membrane protein 1 0.0498894
MCU mitochondrial calcium uniporter 0.0476874
PHF3 PHD finger protein 3 0.0475961
DSPP dentin sialophosphoprotein 0.047214
PTBP3 polypyrimidine tract binding protein 3 0.0470254
KLF6 Kruppel-like factor 6 0.0461884
SQSTM1 sequestosome 1 0.0461794
SMAD3 SMAD family member 3 0.0458066
IFNGR1 interferon gamma receptor 1 0.0457828
APOL1 apolipoprotein L, 1 0.044644
ABHD2 abhydrolase domain containing 2 0.04429
SDC4 syndecan 4 0.0441209
TRIM2 tripartite motif containing 2 0.0437488
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0435756
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0432325
LIMA1 LIM domain and actin binding 1 0.0431523
CATSPERB catsper channel auxiliary subunit beta 0.0427688
STS steroid sulfatase (microsomal), isozyme S 0.0413482
PDZD8 PDZ domain containing 8 0.040883
GOLGB1 golgin B1 0.0402322
SORBS1 sorbin and SH3 domain containing 1 0.0401386
EXT1 exostosin glycosyltransferase 1 0.0400756
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0400431
LPP LIM domain containing preferred translocation partner in lipoma 0.0399993
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0395557
USP53 ubiquitin specific peptidase 53 0.039026
STK24 serine/threonine kinase 24 0.0387245
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0384308
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0381078
ANXA2 annexin A2 0.0377127
SLK STE20-like kinase 0.0375367
LCN2 lipocalin 2 0.0372724
RRBP1 ribosome binding protein 1 0.0368927
ITGA6 integrin, alpha 6 0.0365893
PRKCA protein kinase C, alpha 0.0365206
BTBD9 BTB (POZ) domain containing 9 0.0364178
CTNND1 catenin (cadherin-associated protein), delta 1 0.0362998
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.036255
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0357035
FNDC3B fibronectin type III domain containing 3B 0.0355843
NRIP1 nuclear receptor interacting protein 1 0.0354057
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0349843
JUN jun proto-oncogene 0.0340673
KIAA1217 KIAA1217 0.0340296
SEPTIN9 septin 9 0.0339135
JMJD1C jumonji domain containing 1C 0.0330296
BAIAP2L1 BAI1-associated protein 2-like 1 0.0328866
UBE2H ubiquitin-conjugating enzyme E2H 0.0324334
MYO10 myosin X 0.0323304
AFF1 AF4/FMR2 family, member 1 0.0315175
FNIP2 folliculin interacting protein 2 0.0313948
MSI2 musashi RNA-binding protein 2 0.0312742
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0311553
DST dystonin 0.0310231
ACTN4 actinin, alpha 4 0.0309229
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0308862
AKAP13 A kinase (PRKA) anchor protein 13 0.030838
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0307669
DUSP10 dual specificity phosphatase 10 0.0304591
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0301868
ATP10B ATPase, class V, type 10B 0.0300271
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0294901
USP54 ubiquitin specific peptidase 54 0.0294788
MED13L mediator complex subunit 13-like 0.029431
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0294181
ERRFI1 ERBB receptor feedback inhibitor 1 0.0293262
BCL2L1 BCL2-like 1 0.0290949
KYNU kynureninase 0.0290917
RND3 Rho family GTPase 3 0.0288903
ETV6 ets variant 6 0.0286549
IQGAP1 IQ motif containing GTPase activating protein 1 0.0286337
EPS8 epidermal growth factor receptor pathway substrate 8 0.0280735
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0280553
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0279846
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0275452
CXCL8 chemokine (C-X-C motif) ligand 8 0.0268022
MACC1 metastasis associated in colon cancer 1 0.0267191
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0266394
C6ORF132 chromosome 6 open reading frame 132 0.0265085

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.124131
LYZ lysozyme -0.104671
EPSTI1 epithelial stromal interaction 1 (breast) -0.0882596
FTL ferritin, light polypeptide -0.0794435
TPT1 tumor protein, translationally-controlled 1 -0.0733526
EIF1 eukaryotic translation initiation factor 1 -0.0542934
RPL35A ribosomal protein L35a -0.05121
SP100 SP100 nuclear antigen -0.0463868
TMSB10 thymosin beta 10 -0.0455254
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0454102
STAT1 signal transducer and activator of transcription 1, 91kDa -0.04361
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0423024
RPS6 ribosomal protein S6 -0.0409294
RPS13 ribosomal protein S13 -0.0392286
RPS29 ribosomal protein S29 -0.0388032
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0376174
VIM vimentin -0.0360428
MX1 MX dynamin-like GTPase 1 -0.0359427
HLA-B major histocompatibility complex, class I, B -0.0356485
RPL31 ribosomal protein L31 -0.0354257
RPLP0 ribosomal protein, large, P0 -0.0349629
RPS16 ribosomal protein S16 -0.0343964
NPSR1 neuropeptide S receptor 1 -0.033989
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0336373
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0335627
RPL9 ribosomal protein L9 -0.0333279
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0328495
RAB7A RAB7A, member RAS oncogene family -0.0322714
MUC20 mucin 20, cell surface associated -0.0319533
RPLP1 ribosomal protein, large, P1 -0.0319321
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0318454
IFI27 interferon, alpha-inducible protein 27 -0.0316936
RPS20 ribosomal protein S20 -0.0311576
RIGI RNA sensor RIG-I -0.0309259
RPS3 ribosomal protein S3 -0.0307862
VDAC1 voltage-dependent anion channel 1 -0.0306359
RPS24 ribosomal protein S24 -0.0292848
FTH1 ferritin, heavy polypeptide 1 -0.028818
RABGAP1L RAB GTPase activating protein 1-like -0.0285011
RPL38 ribosomal protein L38 -0.0284224
GNAS GNAS complex locus -0.0283595
TNS4 tensin 4 -0.0279719
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0278015
IGFBP3 insulin-like growth factor binding protein 3 -0.0273275
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0269225
PARD3 par-3 family cell polarity regulator -0.0263823
NUP58 nucleoporin 58 -0.0252638
RPS8 ribosomal protein S8 -0.0252152
RPL37A ribosomal protein L37a -0.0252042
HM13 histocompatibility (minor) 13 -0.0251507
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0244263
HLA-C major histocompatibility complex, class I, C -0.0243583
RPL23 ribosomal protein L23 -0.0242423
RPS27A ribosomal protein S27a -0.0239735
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0238101
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0235855
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0234961
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.023103
ACTG1 actin gamma 1 -0.0229496
DIAPH3 diaphanous-related formin 3 -0.0226794
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0225296
ARL4C ADP-ribosylation factor-like 4C -0.022418
LAP3 leucine aminopeptidase 3 -0.022227
RPL36A ribosomal protein L36a -0.0221554
PDE4D phosphodiesterase 4D, cAMP-specific -0.0221099
RPS25 ribosomal protein S25 -0.0220997
KPNB1 karyopherin (importin) beta 1 -0.0219501
RPS14 ribosomal protein S14 -0.0218365
RAB6A RAB6A, member RAS oncogene family -0.0218307
PLSCR1 phospholipid scramblase 1 -0.0217978
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0210394
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0209704
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0204953
SSR1 signal sequence receptor, alpha -0.0204503
IARS1 isoleucyl-tRNA synthetase 1 -0.0204248
EEF2 eukaryotic translation elongation factor 2 -0.0202704
RFC3 replication factor C (activator 1) 3, 38kDa -0.0202396
PMP22 peripheral myelin protein 22 -0.0202309
ISG15 ISG15 ubiquitin-like modifier -0.0201872
S100A6 S100 calcium binding protein A6 -0.0200951
ENO1 enolase 1, (alpha) -0.0199958
BRCA2 breast cancer 2, early onset -0.0199396
RPS12 ribosomal protein S12 -0.0197471
TUBB4B tubulin, beta 4B class IVb -0.0196389
ZNFX1 zinc finger, NFX1-type containing 1 -0.0195044
FNDC3A fibronectin type III domain containing 3A -0.0190486
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0188556
FN1 fibronectin 1 -0.0185901
RPS23 ribosomal protein S23 -0.0185348
LDHA lactate dehydrogenase A -0.0185296
IFITM3 interferon induced transmembrane protein 3 -0.0184691
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0184498
RNF213 ring finger protein 213 -0.018398
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0182802
SEC31A SEC31 homolog A (S. cerevisiae) -0.0182776
BACE2 beta-site APP-cleaving enzyme 2 -0.0182752
PDIA3 protein disulfide isomerase family A, member 3 -0.0182075
AFMID arylformamidase -0.0181585
CSTB cystatin B (stefin B) -0.0180957
RPS11 ribosomal protein S11 -0.0179879