Pasireotide (acetate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in HCT15 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Pasireotide (acetate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.196064
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.123823
KRT18 keratin 18, type I 0.122942
MKI67 marker of proliferation Ki-67 0.11126
RPS6 ribosomal protein S6 0.106145
MYH9 myosin, heavy chain 9, non-muscle 0.0982506
NDRG1 N-myc downstream regulated 1 0.098106
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0923363
KTN1 kinectin 1 (kinesin receptor) 0.0891638
EZR ezrin 0.0852133
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0726358
TPM3 tropomyosin 3 0.0716521
MT2A metallothionein 2A 0.0681354
POTEF POTE ankyrin domain family, member F 0.0674485
GOLGB1 golgin B1 0.0674251
ASPH aspartate beta-hydroxylase 0.065086
YBX1 Y box binding protein 1 0.0611137
TMSB10 thymosin beta 10 0.0582235
AKAP12 A kinase (PRKA) anchor protein 12 0.0579625
PTMA prothymosin, alpha 0.0575121
DSPP dentin sialophosphoprotein 0.0554139
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0544341
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0538535
HSPA8 heat shock 70kDa protein 8 0.0518724
KIF5B kinesin family member 5B 0.0513436
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0508593
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.050819
BRD2 bromodomain containing 2 0.0504915
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0503458
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0500049
VEGFA vascular endothelial growth factor A 0.0497395
TPM4 tropomyosin 4 0.0483385
PKM pyruvate kinase, muscle 0.0459055
H1-4 H1.4 linker histone, cluster member 0.0445609
ACTG1 actin gamma 1 0.0443044
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0429431
ENO1 enolase 1, (alpha) 0.0428599
RPL3 ribosomal protein L3 0.0424352
AHNAK AHNAK nucleoprotein 0.0424279
TXNIP thioredoxin interacting protein 0.0405941
KRT8 keratin 8, type II 0.0399039
ERRFI1 ERBB receptor feedback inhibitor 1 0.0394017
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0393247
KRT19 keratin 19, type I 0.0386154
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.038052
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0380438
ITGA6 integrin, alpha 6 0.0365265
DST dystonin 0.0362876
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.035647
TPI1 triosephosphate isomerase 1 0.0356229
GOLGA4 golgin A4 0.0347284
EGFR epidermal growth factor receptor 0.0345558
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0334969
TJP1 tight junction protein 1 0.0331475
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0331131
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0328222
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0327082
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0326749
ANXA2 annexin A2 0.032496
S100A10 S100 calcium binding protein A10 0.0321421
RRM2 ribonucleotide reductase M2 0.0306441
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0303167
TRIP11 thyroid hormone receptor interactor 11 0.0302536
RPS2 ribosomal protein S2 0.0300744
NUP50 nucleoporin 50kDa 0.0296595
DIAPH1 diaphanous-related formin 1 0.0296375
SFTPA2 surfactant protein A2 0.02944
TMF1 TATA element modulatory factor 1 0.0293282
SRRM1 serine/arginine repetitive matrix 1 0.0287381
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0285732
FAT1 FAT atypical cadherin 1 0.0284276
SRRM2 serine/arginine repetitive matrix 2 0.0281031
CDCP1 CUB domain containing protein 1 0.0277384
PA2G4 proliferation-associated 2G4, 38kDa 0.0276318
SNX9 sorting nexin 9 0.0276162
SON SON DNA binding protein 0.0273544
H1-2 H1.2 linker histone, cluster member 0.0269647
RRBP1 ribosome binding protein 1 0.0265743
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0263885
ITPRID2 ITPR interacting domain containing 2 0.0263472
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0254648
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0252957
SERBP1 SERPINE1 mRNA binding protein 1 0.0252643
PCM1 pericentriolar material 1 0.0249517
RUNX1 runt-related transcription factor 1 0.0245336
AKAP9 A kinase (PRKA) anchor protein 9 0.0242466
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0240525
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0239491
TOP2B topoisomerase (DNA) II beta 180kDa 0.0236873
TLN1 talin 1 0.0236354
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0234337
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0233351
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.02333
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0232143
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0229842
PLEC plectin 0.022901
SLK STE20-like kinase 0.022755
STIP1 stress-induced phosphoprotein 1 0.0226529
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0225552
RCOR1 REST corepressor 1 0.0222405

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.147957
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.099709
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0777684
FDPS farnesyl diphosphate synthase -0.0712365
RPS24 ribosomal protein S24 -0.0603407
NF1 neurofibromin 1 -0.0531728
DLG1 discs, large homolog 1 (Drosophila) -0.0527859
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0482092
CANX calnexin -0.0482003
KDM4C lysine (K)-specific demethylase 4C -0.0478371
TBC1D22A TBC1 domain family, member 22A -0.0474225
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0459217
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0447039
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.044352
EIF1 eukaryotic translation initiation factor 1 -0.0438702
RAD51B RAD51 paralog B -0.0438361
FTL ferritin, light polypeptide -0.0433904
PCBP2 poly(rC) binding protein 2 -0.0425206
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0421833
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0419227
MBD5 methyl-CpG binding domain protein 5 -0.0406843
PNISR PNN-interacting serine/arginine-rich protein -0.036054
WSB1 WD repeat and SOCS box containing 1 -0.0351468
UBC ubiquitin C -0.0344459
VCL vinculin -0.0340162
CCNI cyclin I -0.0330554
EEF2 eukaryotic translation elongation factor 2 -0.032588
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.032126
NAP1L1 nucleosome assembly protein 1-like 1 -0.0318016
TPT1 tumor protein, translationally-controlled 1 -0.0308617
SERINC5 serine incorporator 5 -0.029125
ARF4 ADP-ribosylation factor 4 -0.0291065
MSMO1 methylsterol monooxygenase 1 -0.0288887
SPDYA speedy/RINGO cell cycle regulator family member A -0.0285895
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0281971
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0281634
RPS27A ribosomal protein S27a -0.0276256
TMEM41B transmembrane protein 41B -0.0273927
BIRC6 baculoviral IAP repeat containing 6 -0.0273642
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0266572
NPEPPS aminopeptidase puromycin sensitive -0.0265124
RPLP0 ribosomal protein, large, P0 -0.0262817
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0261516
IARS1 isoleucyl-tRNA synthetase 1 -0.0259407
CXADR coxsackie virus and adenovirus receptor -0.0258509
RNF213 ring finger protein 213 -0.0257088
ARID4B AT rich interactive domain 4B (RBP1-like) -0.024825
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0247109
BTBD9 BTB (POZ) domain containing 9 -0.0246212
PRELID2 PRELI domain containing 2 -0.0246024
KIAA1217 KIAA1217 -0.0245611
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0243538
EXOC4 exocyst complex component 4 -0.0242619
ZFAND3 zinc finger, AN1-type domain 3 -0.0240543
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0239828
DENND1A DENN/MADD domain containing 1A -0.0239286
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0238438
ADD1 adducin 1 (alpha) -0.0237061
ZMYM2 zinc finger, MYM-type 2 -0.0236845
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0236689
LDLR low density lipoprotein receptor -0.0236307
RHOA ras homolog family member A -0.023399
KDM3A lysine (K)-specific demethylase 3A -0.0232869
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0230775
UBAP2 ubiquitin associated protein 2 -0.0229546
SCARB1 scavenger receptor class B, member 1 -0.0229497
ANKRD17 ankyrin repeat domain 17 -0.0228158
PUM2 pumilio RNA-binding family member 2 -0.0227542
ZNF207 zinc finger protein 207 -0.0225435
WWC2 WW and C2 domain containing 2 -0.0224748
SQSTM1 sequestosome 1 -0.0223554
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0220877
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0220294
USP3 ubiquitin specific peptidase 3 -0.0218417
SDCCAG8 serologically defined colon cancer antigen 8 -0.021743
BRWD3 bromodomain and WD repeat domain containing 3 -0.0215204
SAFB2 scaffold attachment factor B2 -0.0214928
INSIG1 insulin induced gene 1 -0.0209922
HOXB3 homeobox B3 -0.0209116
DYM dymeclin -0.0208771
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0208082
OGA O-GlcNAcase -0.020769
VDAC1 voltage-dependent anion channel 1 -0.0207446
PTPRK protein tyrosine phosphatase, receptor type, K -0.0207187
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0207006
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0205875
SEC31A SEC31 homolog A (S. cerevisiae) -0.0202162
PATJ PATJ crumbs cell polarity complex component -0.0201732
INTS6 integrator complex subunit 6 -0.0197774
ZNF654 zinc finger protein 654 -0.0196112
RABGAP1 RAB GTPase activating protein 1 -0.0193901
TM9SF3 transmembrane 9 superfamily member 3 -0.019374
SPIDR scaffolding protein involved in DNA repair -0.0193672
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0193553
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0191671
TDRD3 tudor domain containing 3 -0.0190601
SHROOM3 shroom family member 3 -0.0190246
ATG10 autophagy related 10 -0.01899
GANAB glucosidase, alpha; neutral AB -0.0189623
HOOK2 hook microtubule-tethering protein 2 -0.0189452