Pasireotide (acetate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.299692
DSPP dentin sialophosphoprotein 0.137776
ERRFI1 ERBB receptor feedback inhibitor 1 0.115287
SPTBN1 spectrin, beta, non-erythrocytic 1 0.112581
SAMD4A sterile alpha motif domain containing 4A 0.0955024
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0790231
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.074561
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0700294
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.057751
MACF1 microtubule-actin crosslinking factor 1 0.0576068
VEGFA vascular endothelial growth factor A 0.0568881
PEG3 paternally expressed 3 0.0540462
MYH9 myosin, heavy chain 9, non-muscle 0.0522849
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0487638
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0475727
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.04659
DSCAM Down syndrome cell adhesion molecule 0.0465253
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0460996
TRIO trio Rho guanine nucleotide exchange factor 0.0458837
ASPH aspartate beta-hydroxylase 0.0441272
TF transferrin 0.0414452
PDLIM5 PDZ and LIM domain 5 0.0404847
DST dystonin 0.0400111
DTNA dystrobrevin, alpha 0.0395093
APLP2 amyloid beta (A4) precursor-like protein 2 0.0376316
ATXN1 ataxin 1 0.0368642
FN1 fibronectin 1 0.0368577
RAI14 retinoic acid induced 14 0.0347228
RNASET2 ribonuclease T2 0.0345502
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0345367
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0339504
GOLGA4 golgin A4 0.0336265
VMP1 vacuole membrane protein 1 0.0332946
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0326315
TNS1 tensin 1 0.0325511
AFF1 AF4/FMR2 family, member 1 0.0319637
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0306646
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0303262
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0300016
AHNAK AHNAK nucleoprotein 0.0297825
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0297646
AFDN afadin, adherens junction formation factor 0.0288528
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0287543
MBNL2 muscleblind-like splicing regulator 2 0.0284798
ITGA6 integrin, alpha 6 0.0282455
ANO6 anoctamin 6 0.0282422
FAT1 FAT atypical cadherin 1 0.0278512
USP47 ubiquitin specific peptidase 47 0.0278191
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0275324
FLNB filamin B, beta 0.0274026
LPP LIM domain containing preferred translocation partner in lipoma 0.0268262
KIF1B kinesin family member 1B 0.0267898
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0266847
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.026199
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0260326
FRMD5 FERM domain containing 5 0.0259988
INSIG2 insulin induced gene 2 0.0259048
SMAD3 SMAD family member 3 0.0257623
PICALM phosphatidylinositol binding clathrin assembly protein 0.0257586
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0257009
FOXP1 forkhead box P1 0.0253208
SVIL supervillin 0.0249803
LMO7 LIM domain 7 0.024842
ADAM9 ADAM metallopeptidase domain 9 0.0247783
FAM107B family with sequence similarity 107, member B 0.0247326
PTK2 protein tyrosine kinase 2 0.0246927
KMT2E lysine (K)-specific methyltransferase 2E 0.0246776
PHF3 PHD finger protein 3 0.0246162
ENO1 enolase 1, (alpha) 0.0245416
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0242654
MYO1B myosin IB 0.0242466
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0241618
DOCK4 dedicator of cytokinesis 4 0.0241065
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0240126
MBNL1 muscleblind-like splicing regulator 1 0.0236506
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.023547
HSPH1 heat shock 105kDa/110kDa protein 1 0.0235259
CLIC4 chloride intracellular channel 4 0.0233803
FNDC3B fibronectin type III domain containing 3B 0.0233705
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0233318
ARHGAP21 Rho GTPase activating protein 21 0.0232511
TOP1 topoisomerase (DNA) I 0.0230279
LAMB1 laminin, beta 1 0.022982
USP34 ubiquitin specific peptidase 34 0.02298
RPL3 ribosomal protein L3 0.0229396
FMNL2 formin-like 2 0.0228238
PPARD peroxisome proliferator-activated receptor delta 0.022559
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0225261
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0224925
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0224579
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0219266
TNS3 tensin 3 0.0218215
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0218106
RBM39 RNA binding motif protein 39 0.0215582
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0215506
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0215348
EHBP1 EH domain binding protein 1 0.0213247
CAMTA1 calmodulin binding transcription activator 1 0.0213057
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0212615
RUNX1 runt-related transcription factor 1 0.0212201

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.368957
MT2A metallothionein 2A -0.15203
TPT1 tumor protein, translationally-controlled 1 -0.102462
APOA2 apolipoprotein A-II -0.0864645
RPS24 ribosomal protein S24 -0.0771153
IGFBP1 insulin-like growth factor binding protein 1 -0.0767262
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0766692
FTL ferritin, light polypeptide -0.0731103
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0677089
RPLP1 ribosomal protein, large, P1 -0.0674902
RPL37A ribosomal protein L37a -0.0643116
RPL11 ribosomal protein L11 -0.0639267
RPL35A ribosomal protein L35a -0.0619318
RPS8 ribosomal protein S8 -0.0554734
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0546376
RPLP2 ribosomal protein, large, P2 -0.054561
RPL31 ribosomal protein L31 -0.0501469
RPS27A ribosomal protein S27a -0.0468957
RPS29 ribosomal protein S29 -0.0428404
RPS13 ribosomal protein S13 -0.0427355
RPS19 ribosomal protein S19 -0.0423289
RPL23 ribosomal protein L23 -0.0410986
RPL9 ribosomal protein L9 -0.0403041
EGR1 early growth response 1 -0.0399436
RPL26 ribosomal protein L26 -0.0378476
RPS16 ribosomal protein S16 -0.0376623
PTMA prothymosin, alpha -0.0351934
LRMDA leucine rich melanocyte differentiation associated -0.0345453
IER3 immediate early response 3 -0.0344464
RPS3 ribosomal protein S3 -0.0334706
RPL38 ribosomal protein L38 -0.0333167
RPS14 ribosomal protein S14 -0.032514
RPS23 ribosomal protein S23 -0.0320746
ISG15 ISG15 ubiquitin-like modifier -0.032071
RPS10 ribosomal protein S10 -0.0318842
SOX5 SRY (sex determining region Y)-box 5 -0.0315251
GPC3 glypican 3 -0.0312066
RPS21 ribosomal protein S21 -0.0297678
APOC1 apolipoprotein C-I -0.0291956
APOE apolipoprotein E -0.0284728
APOB apolipoprotein B -0.0279813
VCL vinculin -0.0274015
RACK1 receptor for activated C kinase 1 -0.0266955
AHSG alpha-2-HS-glycoprotein -0.0266036
RPL7A ribosomal protein L7a -0.0265191
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0262255
S100A9 S100 calcium binding protein A9 -0.0260634
RPL12 ribosomal protein L12 -0.0259653
RPS25 ribosomal protein S25 -0.0256295
RPLP0 ribosomal protein, large, P0 -0.0253896
TMSB10 thymosin beta 10 -0.0251262
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0250335
RPS12 ribosomal protein S12 -0.0250211
RPL36A ribosomal protein L36a -0.0249218
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0241415
RPL30 ribosomal protein L30 -0.0240724
RPS6 ribosomal protein S6 -0.0240032
RPL34 ribosomal protein L34 -0.0238228
IFI6 interferon, alpha-inducible protein 6 -0.0235841
RPL5 ribosomal protein L5 -0.0228653
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0226446
EIF1 eukaryotic translation initiation factor 1 -0.0223819
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0220492
CST3 cystatin C -0.0214112
MX2 MX dynamin-like GTPase 2 -0.0209667
B2M beta-2-microglobulin -0.0208885
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0208783
C3 complement component 3 -0.0207553
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0199608
GDF15 growth differentiation factor 15 -0.0198878
RPL27 ribosomal protein L27 -0.0194826
RPS15 ribosomal protein S15 -0.0194254
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.01933
RPS17 ribosomal protein S17 -0.0190886
RPL36 ribosomal protein L36 -0.0188807
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0188182
RPS5 ribosomal protein S5 -0.018747
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0186951
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0186644
H3-3B H3.3 histone B -0.0184355
RPL15 ribosomal protein L15 -0.018113
KPNB1 karyopherin (importin) beta 1 -0.0177133
AMBP alpha-1-microglobulin/bikunin precursor -0.0170898
RPL37 ribosomal protein L37 -0.0169548
RPS11 ribosomal protein S11 -0.0169348
IFIH1 interferon induced with helicase C domain 1 -0.0169094
ACSS3 acyl-CoA synthetase short-chain family member 3 -0.0168124
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0167605
IFITM1 interferon induced transmembrane protein 1 -0.0167159
IFITM3 interferon induced transmembrane protein 3 -0.0166394
RPL32 ribosomal protein L32 -0.0165039
RPL7 ribosomal protein L7 -0.0160428
PLIN2 perilipin 2 -0.015877
RPL19 ribosomal protein L19 -0.0157539
APOC2 apolipoprotein C-II -0.0157519
EML4 echinoderm microtubule associated protein like 4 -0.0157225
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0156524
ANGPTL8 angiopoietin like 8 -0.0154778
RPL10A ribosomal protein L10a -0.0153064
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0152276