Pasireotide (acetate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.170376
CLU clusterin 0.137157
MYH9 myosin, heavy chain 9, non-muscle 0.132185
AHNAK AHNAK nucleoprotein 0.125375
MSN moesin 0.116037
MT2A metallothionein 2A 0.103094
FLNB filamin B, beta 0.0999051
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0943054
NDRG1 N-myc downstream regulated 1 0.0905094
TPM3 tropomyosin 3 0.0886005
YBX1 Y box binding protein 1 0.086552
APLP2 amyloid beta (A4) precursor-like protein 2 0.0767606
MKI67 marker of proliferation Ki-67 0.0758379
SLK STE20-like kinase 0.0746017
RPS2 ribosomal protein S2 0.0717456
RPS12 ribosomal protein S12 0.0716093
DSCAM Down syndrome cell adhesion molecule 0.0712518
TMSB10 thymosin beta 10 0.0708579
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0667493
BHLHE40 basic helix-loop-helix family, member e40 0.0618265
BCL2L1 BCL2-like 1 0.0611468
HSPA8 heat shock 70kDa protein 8 0.060736
LAMC2 laminin, gamma 2 0.0602449
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0595336
TXNIP thioredoxin interacting protein 0.0592272
SMAD3 SMAD family member 3 0.0574867
PLEC plectin 0.057164
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0555961
GOLGA4 golgin A4 0.0555785
LMO7 LIM domain 7 0.0553014
ASPH aspartate beta-hydroxylase 0.0549666
VCL vinculin 0.0545591
KTN1 kinectin 1 (kinesin receptor) 0.0535834
MYOF myoferlin 0.0526143
CENPF centromere protein F, 350/400kDa 0.0516426
CAPRIN2 caprin family member 2 0.0500603
DST dystonin 0.0496314
MACF1 microtubule-actin crosslinking factor 1 0.0488437
RPL8 ribosomal protein L8 0.0476667
RPS8 ribosomal protein S8 0.0476395
TGM2 transglutaminase 2 0.0468234
RPS19 ribosomal protein S19 0.0467622
EZR ezrin 0.0465974
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0453994
OGA O-GlcNAcase 0.0447598
ITGA6 integrin, alpha 6 0.0441651
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.043865
ARRDC3 arrestin domain containing 3 0.0432365
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0431539
RPL3 ribosomal protein L3 0.0430378
EHBP1L1 EH domain binding protein 1-like 1 0.0421429
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0412238
PLAT plasminogen activator, tissue 0.039726
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.039697
MBNL1 muscleblind-like splicing regulator 1 0.0393855
TPX2 TPX2, microtubule-associated 0.0392348
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0377502
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0373541
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0372461
BCAR3 breast cancer anti-estrogen resistance 3 0.0368362
SFTPA2 surfactant protein A2 0.0368237
TMF1 TATA element modulatory factor 1 0.0365342
PRRC2C proline-rich coiled-coil 2C 0.0363755
MEF2A myocyte enhancer factor 2A 0.0358971
S100A9 S100 calcium binding protein A9 0.0343696
RPL21 ribosomal protein L21 0.0343278
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0342066
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0338273
RPL32 ribosomal protein L32 0.0337851
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0334038
RPS3 ribosomal protein S3 0.0332293
AHNAK2 AHNAK nucleoprotein 2 0.0330005
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.032838
CEP250 centrosomal protein 250kDa 0.0322068
RPL19 ribosomal protein L19 0.0320335
SEPTIN9 septin 9 0.0319659
RPL12 ribosomal protein L12 0.0318973
RBM39 RNA binding motif protein 39 0.0318669
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0318112
EEF1G eukaryotic translation elongation factor 1 gamma 0.0315673
RPL37 ribosomal protein L37 0.0315238
TAC4 tachykinin 4 (hemokinin) 0.0315188
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.03125
ITPRID2 ITPR interacting domain containing 2 0.0310064
PRELID2 PRELI domain containing 2 0.0305689
RPL11 ribosomal protein L11 0.0304331
NRIP1 nuclear receptor interacting protein 1 0.0300095
MCL1 myeloid cell leukemia 1 0.0297857
APP amyloid beta (A4) precursor protein 0.0295456
MEGF6 multiple EGF-like-domains 6 0.0293481
CUL4B cullin 4B 0.0291693
ARHGAP21 Rho GTPase activating protein 21 0.0282669
YBX3 Y box binding protein 3 0.0280147
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0278089
ACTN4 actinin, alpha 4 0.0276922
VEGFA vascular endothelial growth factor A 0.0276557
LUZP1 leucine zipper protein 1 0.0274949
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0274541
AKAP12 A kinase (PRKA) anchor protein 12 0.0273517
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0273316

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.275119
TIMP3 TIMP metallopeptidase inhibitor 3 -0.239024
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.127525
IGF2 insulin-like growth factor 2 -0.0876633
PTMA prothymosin, alpha -0.0698411
DPYD dihydropyrimidine dehydrogenase -0.0698396
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0583335
ABI3BP ABI family, member 3 (NESH) binding protein -0.0560158
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0550326
SULF1 sulfatase 1 -0.0504037
ZMYND8 zinc finger, MYND-type containing 8 -0.0490527
HSPG2 heparan sulfate proteoglycan 2 -0.0446175
CAV1 caveolin 1, caveolae protein, 22kDa -0.0424309
MTSS1 metastasis suppressor 1 -0.0419678
CDK6 cyclin-dependent kinase 6 -0.0381658
HLA-B major histocompatibility complex, class I, B -0.0367601
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0365762
VDAC1 voltage-dependent anion channel 1 -0.0363134
EXT1 exostosin glycosyltransferase 1 -0.0362372
RABGAP1L RAB GTPase activating protein 1-like -0.0353032
RPL35A ribosomal protein L35a -0.0349469
SP100 SP100 nuclear antigen -0.0332632
HMGA2 high mobility group AT-hook 2 -0.0327872
PSD3 pleckstrin and Sec7 domain containing 3 -0.0323948
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0322738
PDE4D phosphodiesterase 4D, cAMP-specific -0.0319179
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.031818
TNS3 tensin 3 -0.031669
ABLIM1 actin binding LIM protein 1 -0.0313177
THBD thrombomodulin -0.0309194
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0299934
AOPEP aminopeptidase O (putative) -0.0297764
TPT1 tumor protein, translationally-controlled 1 -0.0286469
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0283417
HLA-E major histocompatibility complex, class I, E -0.0283092
C4BPB complement component 4 binding protein, beta -0.028184
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0278861
ALCAM activated leukocyte cell adhesion molecule -0.027871
MAML2 mastermind-like 2 (Drosophila) -0.0276236
S100A11 S100 calcium binding protein A11 -0.0273242
NPAS2 neuronal PAS domain protein 2 -0.0272916
RAD51B RAD51 paralog B -0.0269047
PALLD palladin, cytoskeletal associated protein -0.0265783
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0261015
MBNL2 muscleblind-like splicing regulator 2 -0.0259099
IFI16 interferon, gamma-inducible protein 16 -0.0258099
TSC22D1 TSC22 domain family, member 1 -0.0257067
ARF1 ADP-ribosylation factor 1 -0.0254498
FRMD4B FERM domain containing 4B -0.025072
RPL39 ribosomal protein L39 -0.0250047
RPS25 ribosomal protein S25 -0.0245947
MX2 MX dynamin-like GTPase 2 -0.0244948
RPS24 ribosomal protein S24 -0.0243975
AGMO alkylglycerol monooxygenase -0.0240839
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0240251
KIAA1671 KIAA1671 -0.0239319
FOXP1 forkhead box P1 -0.0237251
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0232203
IARS1 isoleucyl-tRNA synthetase 1 -0.0230065
TFPI2 tissue factor pathway inhibitor 2 -0.0229373
RPL27A ribosomal protein L27a -0.0228249
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0226808
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0226347
FOXO1 forkhead box O1 -0.0225881
ITGB8 integrin, beta 8 -0.0224723
ZFAND3 zinc finger, AN1-type domain 3 -0.0219653
TMSB4X thymosin beta 4, X-linked -0.0219157
ATP5F1B ATP synthase F1 subunit beta -0.0218832
KCTD12 potassium channel tetramerization domain containing 12 -0.0216232
IFITM1 interferon induced transmembrane protein 1 -0.0214937
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0214231
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0211715
PERP PERP, TP53 apoptosis effector -0.0211504
CD44 CD44 molecule (Indian blood group) -0.0210263
TRIM56 tripartite motif containing 56 -0.0209178
RPLP0 ribosomal protein, large, P0 -0.0207931
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0206813
RASAL2 RAS protein activator like 2 -0.0204935
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0203583
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0203298
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0202855
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.020223
NFIA nuclear factor I/A -0.0201945
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0201483
PTPRG protein tyrosine phosphatase, receptor type, G -0.0200037
SAMHD1 SAM domain and HD domain 1 -0.0198726
SESTD1 SEC14 and spectrin domains 1 -0.0195799
LITAF lipopolysaccharide-induced TNF factor -0.0195255
FSCN1 fascin actin-bundling protein 1 -0.0193776
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0193697
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.019057
HM13 histocompatibility (minor) 13 -0.0188899
NF1 neurofibromin 1 -0.0187253
EPSTI1 epithelial stromal interaction 1 (breast) -0.0186419
SMYD3 SET and MYND domain containing 3 -0.0185127
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0185076
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.018425
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0183061
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0180075
EXOC4 exocyst complex component 4 -0.0178833