Pasireotide (acetate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.365301
RPS6 ribosomal protein S6 0.223163
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.171961
DTNA dystrobrevin, alpha 0.11847
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0883422
DST dystonin 0.0866068
MYO10 myosin X 0.0865329
VIM vimentin 0.0780167
RUNX1 runt-related transcription factor 1 0.0756829
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0756553
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0685726
KTN1 kinectin 1 (kinesin receptor) 0.0646164
CALD1 caldesmon 1 0.0640138
MKI67 marker of proliferation Ki-67 0.0635661
SAMD4A sterile alpha motif domain containing 4A 0.0591311
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0565635
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0560249
FRMD6 FERM domain containing 6 0.055786
JMJD1C jumonji domain containing 1C 0.0543631
HSPA8 heat shock 70kDa protein 8 0.0505622
CD44 CD44 molecule (Indian blood group) 0.0495352
MYH9 myosin, heavy chain 9, non-muscle 0.0489462
HDAC9 histone deacetylase 9 0.0484619
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0482007
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0470018
ERRFI1 ERBB receptor feedback inhibitor 1 0.0451606
RPS2 ribosomal protein S2 0.0424567
YBX1 Y box binding protein 1 0.0392283
EIF4B eukaryotic translation initiation factor 4B 0.0378475
RPL3 ribosomal protein L3 0.0377344
MSN moesin 0.0375609
MARCHF4 membrane associated ring-CH-type finger 4 0.0369299
EEF1G eukaryotic translation elongation factor 1 gamma 0.0365566
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0364194
H1-4 H1.4 linker histone, cluster member 0.0360327
RND3 Rho family GTPase 3 0.0349692
BCAR3 breast cancer anti-estrogen resistance 3 0.0345297
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.032913
TXNIP thioredoxin interacting protein 0.0326573
ERBIN erbb2 interacting protein 0.0326043
ENKUR enkurin, TRPC channel interacting protein 0.0321355
BTG1 B-cell translocation gene 1, anti-proliferative 0.0309022
ADAM9 ADAM metallopeptidase domain 9 0.0307386
ELL2 elongation factor, RNA polymerase II, 2 0.03035
TPM3 tropomyosin 3 0.0302633
LIMA1 LIM domain and actin binding 1 0.0298489
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0297049
PICALM phosphatidylinositol binding clathrin assembly protein 0.0293136
RPL5 ribosomal protein L5 0.0292767
IRS2 insulin receptor substrate 2 0.0290015
BRD2 bromodomain containing 2 0.0287599
BPTF bromodomain PHD finger transcription factor 0.0282603
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.028083
KIF5B kinesin family member 5B 0.0279815
PUM2 pumilio RNA-binding family member 2 0.0279769
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0278494
CDK6 cyclin-dependent kinase 6 0.0278044
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0277466
CORO1C coronin, actin binding protein, 1C 0.0271165
UGCG UDP-glucose ceramide glucosyltransferase 0.0270199
KMT2E lysine (K)-specific methyltransferase 2E 0.0269006
ARFGEF3 ARFGEF family member 3 0.0266887
LIMS1 LIM and senescent cell antigen-like domains 1 0.0263958
PALM2AKAP2 PALM2 and AKAP2 fusion 0.026284
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0262432
SPAG9 sperm associated antigen 9 0.0260578
TRIP12 thyroid hormone receptor interactor 12 0.0260292
RPL19 ribosomal protein L19 0.0253294
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0253262
GOLGA4 golgin A4 0.0253216
GLS2 glutaminase 2 (liver, mitochondrial) 0.0251425
WNK1 WNK lysine deficient protein kinase 1 0.0248592
MAP1B microtubule-associated protein 1B 0.0248436
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0247764
HAS2 hyaluronan synthase 2 0.0245321
ARHGAP21 Rho GTPase activating protein 21 0.0244395
SCAF11 SR-related CTD-associated factor 11 0.0243982
MYO6 myosin VI 0.0242122
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0241293
TMF1 TATA element modulatory factor 1 0.0238743
PSME4 proteasome (prosome, macropain) activator subunit 4 0.023786
RB1 retinoblastoma 1 0.0235814
NGLY1 N-glycanase 1 0.023442
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0230587
RPL4 ribosomal protein L4 0.0228649
TAOK1 TAO kinase 1 0.0228242
PRRC2C proline-rich coiled-coil 2C 0.0227946
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0227917
NUP58 nucleoporin 58 0.0227792
MXI1 MAX interactor 1, dimerization protein 0.022772
ZNF638 zinc finger protein 638 0.022594
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0225255
ITGA6 integrin, alpha 6 0.0224646
MALT1 MALT1 paracaspase 0.0223782
YBX3 Y box binding protein 3 0.0223147
RPS4X ribosomal protein S4, X-linked 0.0219986
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0217159
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0214363
RPL12 ribosomal protein L12 0.0212911
TPM4 tropomyosin 4 0.0212763

decreased expression

Symbol Name Standardized Value
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.173856
GPC6 glypican 6 -0.133068
TMSB10 thymosin beta 10 -0.112074
CDH13 cadherin 13 -0.0928376
LSAMP limbic system-associated membrane protein -0.0837886
EFNA5 ephrin-A5 -0.0770775
PDE4D phosphodiesterase 4D, cAMP-specific -0.0759046
PRKG1 protein kinase, cGMP-dependent, type I -0.0698236
NALF1 NALCN channel auxiliary factor 1 -0.0673302
ZNF804A zinc finger protein 804A -0.0582188
KIAA1549L KIAA1549-like -0.0580985
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0540705
PTPRG protein tyrosine phosphatase, receptor type, G -0.0536964
KIAA1217 KIAA1217 -0.0536651
ACTG1 actin gamma 1 -0.0520276
PHACTR1 phosphatase and actin regulator 1 -0.0508921
UBC ubiquitin C -0.0489571
RPS27A ribosomal protein S27a -0.0476076
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0468916
ASPH aspartate beta-hydroxylase -0.0464128
FLNA filamin A, alpha -0.0452667
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0440678
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0439593
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0435026
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0434408
RAD51B RAD51 paralog B -0.0407898
RPS24 ribosomal protein S24 -0.0400604
DPYD dihydropyrimidine dehydrogenase -0.0392309
PTCHD4 patched domain containing 4 -0.036868
FN1 fibronectin 1 -0.0360537
BNC2 basonuclin 2 -0.0359179
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0359109
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.034466
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0329091
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0324124
C2CD2 C2 calcium-dependent domain containing 2 -0.0318045
FNDC3B fibronectin type III domain containing 3B -0.0316229
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0306315
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0299588
POTEF POTE ankyrin domain family, member F -0.0292986
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0292878
SBF2 SET binding factor 2 -0.0291631
TENM2 teneurin transmembrane protein 2 -0.0287537
CDK14 cyclin-dependent kinase 14 -0.0278196
ADGRB3 adhesion G protein-coupled receptor B3 -0.027733
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0272867
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0268534
RIGI RNA sensor RIG-I -0.0264614
TRPS1 trichorhinophalangeal syndrome I -0.0263676
LOC112694756 uncharaterized LOC112694756 -0.0260868
PCBP2 poly(rC) binding protein 2 -0.0258252
MBD5 methyl-CpG binding domain protein 5 -0.0257136
TBC1D5 TBC1 domain family, member 5 -0.025322
RASA3 RAS p21 protein activator 3 -0.0251057
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.024723
PCDH9 protocadherin 9 -0.0243404
DNER delta/notch-like EGF repeat containing -0.0241595
NAV1 neuron navigator 1 -0.0241295
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0239823
CAST calpastatin -0.0239326
WSB1 WD repeat and SOCS box containing 1 -0.0237782
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0235946
SAMD3 sterile alpha motif domain containing 3 -0.0235925
KDM4B lysine (K)-specific demethylase 4B -0.0232205
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0232043
PRELID2 PRELI domain containing 2 -0.0224239
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0224214
CFAP20DC CFAP20 domain containing -0.0222832
IFI16 interferon, gamma-inducible protein 16 -0.0222473
KDM4C lysine (K)-specific demethylase 4C -0.0221095
ARHGAP18 Rho GTPase activating protein 18 -0.0217234
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0216159
PTK2 protein tyrosine kinase 2 -0.0215228
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.020644
PGK1 phosphoglycerate kinase 1 -0.0204661
NLGN1 neuroligin 1 -0.0203143
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0202697
ZMYM2 zinc finger, MYM-type 2 -0.0202029
NABP1 nucleic acid binding protein 1 -0.0197884
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0197867
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0196905
RNF144A ring finger protein 144A -0.0196657
AEBP2 AE binding protein 2 -0.019336
DIAPH2 diaphanous-related formin 2 -0.0193323
NRP2 neuropilin 2 -0.0191266
NFIA nuclear factor I/A -0.0190314
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0189892
CANX calnexin -0.0188686
JARID2 jumonji, AT rich interactive domain 2 -0.0186453
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0185498
LDHA lactate dehydrogenase A -0.0184935
DIAPH3 diaphanous-related formin 3 -0.0184499
MYOF myoferlin -0.0182046
PTPRD protein tyrosine phosphatase, receptor type, D -0.0181849
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0180583
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0180231
TUBB tubulin, beta class I -0.0179774
TPT1 tumor protein, translationally-controlled 1 -0.0179062
CD109 CD109 molecule -0.017846
TEX14 testis expressed 14 -0.0178282