Pasireotide (acetate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.322662
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.135857
TXNRD1 thioredoxin reductase 1 0.107455
TPM3 tropomyosin 3 0.0954899
TFPI2 tissue factor pathway inhibitor 2 0.0746968
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0735031
YBX3 Y box binding protein 3 0.0726715
ERRFI1 ERBB receptor feedback inhibitor 1 0.0701545
TM4SF1 transmembrane 4 L six family member 1 0.0626602
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0604245
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0598097
HSPA8 heat shock 70kDa protein 8 0.0582094
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0571665
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0556936
RPS8 ribosomal protein S8 0.0496805
GOLGB1 golgin B1 0.0427896
YBX1 Y box binding protein 1 0.0427451
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0423715
EIF3A eukaryotic translation initiation factor 3, subunit A 0.042009
RPS12 ribosomal protein S12 0.0418987
BZW1 basic leucine zipper and W2 domains 1 0.0411808
ELL2 elongation factor, RNA polymerase II, 2 0.0410557
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0407095
RPL37A ribosomal protein L37a 0.0396318
RPS6 ribosomal protein S6 0.0378059
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0377525
MYH9 myosin, heavy chain 9, non-muscle 0.036687
RPS2 ribosomal protein S2 0.0362419
RPS3 ribosomal protein S3 0.0349549
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0346293
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0341343
KTN1 kinectin 1 (kinesin receptor) 0.0340881
EEF1G eukaryotic translation elongation factor 1 gamma 0.0340214
DST dystonin 0.0329786
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0329729
TPT1 tumor protein, translationally-controlled 1 0.0309457
RPL37 ribosomal protein L37 0.0309385
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0307852
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0302847
DSPP dentin sialophosphoprotein 0.0301295
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0300302
MKI67 marker of proliferation Ki-67 0.029894
RSL1D1 ribosomal L1 domain containing 1 0.0297036
IPO7 importin 7 0.0266632
VCP valosin containing protein 0.0266308
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0254853
RPS7 ribosomal protein S7 0.0253594
RPS27 ribosomal protein S27 0.0253426
MARCHF4 membrane associated ring-CH-type finger 4 0.0250197
RPL26 ribosomal protein L26 0.0246424
GOLGA4 golgin A4 0.0245352
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0243737
RPL3 ribosomal protein L3 0.0242214
RPL4 ribosomal protein L4 0.0242019
KRT18 keratin 18, type I 0.0240897
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0237533
UBC ubiquitin C 0.0236999
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0229393
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0229242
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0228615
EIF4B eukaryotic translation initiation factor 4B 0.0227996
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0227694
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0226955
STC1 stanniocalcin 1 0.0225752
TMEM41B transmembrane protein 41B 0.0224648
AHNAK AHNAK nucleoprotein 0.0221914
RPS4X ribosomal protein S4, X-linked 0.0220829
RPL31 ribosomal protein L31 0.021855
RPL13A ribosomal protein L13a 0.0215359
RPS29 ribosomal protein S29 0.0213594
RPS27A ribosomal protein S27a 0.0213369
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0213243
FUS FUS RNA binding protein 0.0211675
BHLHE40 basic helix-loop-helix family, member e40 0.0211418
BIRC2 baculoviral IAP repeat containing 2 0.0207037
CAVIN1 caveolae associated protein 1 0.0206822
NAP1L1 nucleosome assembly protein 1-like 1 0.0205846
RTN4 reticulon 4 0.020531
TPI1 triosephosphate isomerase 1 0.020507
WBP11 WW domain binding protein 11 0.0205034
AKAP9 A kinase (PRKA) anchor protein 9 0.0203633
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0200718
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0199731
TOP2B topoisomerase (DNA) II beta 180kDa 0.0196342
RPLP1 ribosomal protein, large, P1 0.0195211
BRD2 bromodomain containing 2 0.019498
OGA O-GlcNAcase 0.0192997
ASPH aspartate beta-hydroxylase 0.019174
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0191297
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0189686
EIF1 eukaryotic translation initiation factor 1 0.0189234
ATAD2 ATPase family, AAA domain containing 2 0.0188423
CSDE1 cold shock domain containing E1, RNA-binding 0.0188233
RRM2 ribonucleotide reductase M2 0.0187809
PAPOLA poly(A) polymerase alpha 0.0187762
RPS17 ribosomal protein S17 0.0187359
SET SET nuclear proto-oncogene 0.0186505
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0186132
KIF5B kinesin family member 5B 0.0185947
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0183815

decreased expression

Symbol Name Standardized Value
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0832004
TMSB10 thymosin beta 10 -0.071725
EGR1 early growth response 1 -0.0711148
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0706257
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0675791
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0653299
USP34 ubiquitin specific peptidase 34 -0.0580594
POTEF POTE ankyrin domain family, member F -0.0569115
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0561587
TAS2R14 taste receptor, type 2, member 14 -0.0527056
THSD4 thrombospondin, type I, domain containing 4 -0.0518309
NF1 neurofibromin 1 -0.0511739
ZBTB20 zinc finger and BTB domain containing 20 -0.0497469
OSMR oncostatin M receptor -0.0494854
RAD51B RAD51 paralog B -0.0482208
RYR3 ryanodine receptor 3 -0.0475646
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0466703
HMGA2 high mobility group AT-hook 2 -0.0440696
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0438373
ZFAND3 zinc finger, AN1-type domain 3 -0.0416825
IGF2 insulin-like growth factor 2 -0.0412368
ATXN1 ataxin 1 -0.041006
AFF3 AF4/FMR2 family, member 3 -0.0397117
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0397082
PDE10A phosphodiesterase 10A -0.0396009
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0392162
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0381061
EGFR epidermal growth factor receptor -0.0376715
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0374205
PRH1 proline-rich protein HaeIII subfamily 1 -0.0370114
PTK2 protein tyrosine kinase 2 -0.0370103
VIM vimentin -0.0369469
RNF213 ring finger protein 213 -0.0357627
KDM2A lysine (K)-specific demethylase 2A -0.0354801
PFN1 profilin 1 -0.0351502
EML4 echinoderm microtubule associated protein like 4 -0.0336687
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0335432
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0330333
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0327015
SMAD3 SMAD family member 3 -0.0326668
BSG basigin (Ok blood group) -0.0321752
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0308818
ZNF207 zinc finger protein 207 -0.0308784
ATG7 autophagy related 7 -0.0304116
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0303796
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0303406
FNDC3B fibronectin type III domain containing 3B -0.0302496
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0301182
PYGL phosphorylase, glycogen, liver -0.0296394
UBE2H ubiquitin-conjugating enzyme E2H -0.0293036
TAPBP TAP binding protein (tapasin) -0.0285148
NCOA7 nuclear receptor coactivator 7 -0.0282471
FMNL2 formin-like 2 -0.0277701
BBX bobby sox homolog (Drosophila) -0.0276212
HLA-B major histocompatibility complex, class I, B -0.0275297
BIRC6 baculoviral IAP repeat containing 6 -0.0270697
KDM4B lysine (K)-specific demethylase 4B -0.0270271
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0269997
RAB7A RAB7A, member RAS oncogene family -0.0268421
IGF1R insulin-like growth factor 1 receptor -0.0265571
ACTN1 actinin, alpha 1 -0.0265548
FMN1 formin 1 -0.0262058
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.025892
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0255427
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0252599
BABAM2 BRISC and BRCA1 A complex member 2 -0.0251427
RSF1 remodeling and spacing factor 1 -0.0251412
PTMS parathymosin -0.0250196
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0248731
FAF1 Fas (TNFRSF6) associated factor 1 -0.0248249
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0248027
ZNF609 zinc finger protein 609 -0.0247563
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0245505
DENND5B DENN/MADD domain containing 5B -0.0245315
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0238173
SBF2 SET binding factor 2 -0.0233927
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0233307
DENND1A DENN/MADD domain containing 1A -0.023102
SDK1 sidekick cell adhesion molecule 1 -0.0230373
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0229604
FBXO11 F-box protein 11 -0.0228777
RSRC1 arginine/serine-rich coiled-coil 1 -0.0227632
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0225666
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0225042
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0222393
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0222176
WASF2 WAS protein family, member 2 -0.0222175
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0221263
WDPCP WD repeat containing planar cell polarity effector -0.0218916
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0218459
TMEM131 transmembrane protein 131 -0.0216307
CCDC91 coiled-coil domain containing 91 -0.0215929
IFI6 interferon, alpha-inducible protein 6 -0.0215048
CUX1 cut-like homeobox 1 -0.0214694
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0212848
CLIP1 CAP-GLY domain containing linker protein 1 -0.021284
MCTP1 multiple C2 domains, transmembrane 1 -0.0212449
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0210802
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0208822
ANKRD12 ankyrin repeat domain 12 -0.0208735