Pasireotide (acetate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.157093
RPS6 ribosomal protein S6 0.135386
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.128643
SPTBN1 spectrin, beta, non-erythrocytic 1 0.121377
DST dystonin 0.120847
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.105971
MYOF myoferlin 0.103188
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0994806
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0988899
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0876837
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0852101
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0841655
KYNU kynureninase 0.0832161
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0784291
TRIO trio Rho guanine nucleotide exchange factor 0.0746426
MCL1 myeloid cell leukemia 1 0.0701745
EFNA5 ephrin-A5 0.0693523
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0662427
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0660319
PRRC2C proline-rich coiled-coil 2C 0.065091
RPL19 ribosomal protein L19 0.0639859
HSPA8 heat shock 70kDa protein 8 0.063807
TXNRD1 thioredoxin reductase 1 0.0613838
NAMPT nicotinamide phosphoribosyltransferase 0.0590972
EZR ezrin 0.0590687
PABPC1 poly(A) binding protein, cytoplasmic 1 0.056645
PM20D1 peptidase M20 domain containing 1 0.0554309
BASP1 brain abundant, membrane attached signal protein 1 0.0552229
COL8A1 collagen, type VIII, alpha 1 0.0547715
RPL3 ribosomal protein L3 0.0547603
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0544429
TPM3 tropomyosin 3 0.0544193
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0531625
COL5A2 collagen, type V, alpha 2 0.0528352
SAMD4A sterile alpha motif domain containing 4A 0.0511596
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.050962
ESYT2 extended synaptotagmin-like protein 2 0.0508058
EEF2 eukaryotic translation elongation factor 2 0.0507926
SH3KBP1 SH3-domain kinase binding protein 1 0.0501643
MKI67 marker of proliferation Ki-67 0.0500642
EEF1G eukaryotic translation elongation factor 1 gamma 0.0499468
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0496865
IGFBP3 insulin-like growth factor binding protein 3 0.0491661
PDLIM5 PDZ and LIM domain 5 0.0489372
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0483735
RPS8 ribosomal protein S8 0.0479631
AHNAK AHNAK nucleoprotein 0.0475619
TGFBR1 transforming growth factor, beta receptor 1 0.0475415
RGS2 regulator of G-protein signaling 2 0.0472534
GRAMD1B GRAM domain containing 1B 0.0471033
CXCL8 chemokine (C-X-C motif) ligand 8 0.0466452
APLP2 amyloid beta (A4) precursor-like protein 2 0.0465815
VIM vimentin 0.0465383
GDA guanine deaminase 0.0465067
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0464682
CENPF centromere protein F, 350/400kDa 0.0458074
COL4A6 collagen, type IV, alpha 6 0.0456591
INHBA inhibin, beta A 0.045477
KTN1 kinectin 1 (kinesin receptor) 0.0454229
RPS4X ribosomal protein S4, X-linked 0.0452247
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0451861
UBC ubiquitin C 0.0451423
RAB3B RAB3B, member RAS oncogene family 0.0449847
LIMCH1 LIM and calponin homology domains 1 0.0449457
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0441364
FLNB filamin B, beta 0.0438664
ENO1 enolase 1, (alpha) 0.0437708
FN1 fibronectin 1 0.0436157
ANXA1 annexin A1 0.0431766
ELL2 elongation factor, RNA polymerase II, 2 0.0430918
PGK1 phosphoglycerate kinase 1 0.0430124
TMSB10 thymosin beta 10 0.0428442
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0426611
CTSC cathepsin C 0.0425081
MYH9 myosin, heavy chain 9, non-muscle 0.042381
CANX calnexin 0.0421605
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0420684
SFTPA2 surfactant protein A2 0.0420117
RPL12 ribosomal protein L12 0.0418679
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0412576
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0409324
RPL23 ribosomal protein L23 0.0402471
MSN moesin 0.039994
RPLP1 ribosomal protein, large, P1 0.0399934
EIF4B eukaryotic translation initiation factor 4B 0.0388969
BZW1 basic leucine zipper and W2 domains 1 0.0388924
GNAS GNAS complex locus 0.0380776
GOLGA4 golgin A4 0.0379911
RPS2 ribosomal protein S2 0.0379381
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0372253
RPS27 ribosomal protein S27 0.0371643
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0369796
OGA O-GlcNAcase 0.0365514
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0363948
MFF mitochondrial fission factor 0.036015
PKM pyruvate kinase, muscle 0.0359299
WWTR1 WW domain containing transcription regulator 1 0.0358806
IQGAP1 IQ motif containing GTPase activating protein 1 0.0358639
EIF4A1 eukaryotic translation initiation factor 4A1 0.0356283
YBX1 Y box binding protein 1 0.0355957

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.197244
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.104417
NALF1 NALCN channel auxiliary factor 1 -0.0825267
CDH13 cadherin 13 -0.075882
SMYD3 SET and MYND domain containing 3 -0.0682123
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0584971
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.047012
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0459592
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0456226
KIAA0825 KIAA0825 -0.0451321
ADGRD1 adhesion G protein-coupled receptor D1 -0.0435951
WARS1 tryptophanyl-tRNA synthetase 1 -0.0360021
NCKAP5 NCK-associated protein 5 -0.0345431
CTNND2 catenin (cadherin-associated protein), delta 2 -0.033296
SOX6 SRY (sex determining region Y)-box 6 -0.0310923
PTPRM protein tyrosine phosphatase, receptor type, M -0.0305192
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0304987
HLA-B major histocompatibility complex, class I, B -0.0287879
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0283403
BCAS3 breast carcinoma amplified sequence 3 -0.0274818
PCDH15 protocadherin-related 15 -0.0261165
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0257892
CADM2 cell adhesion molecule 2 -0.0254114
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0234996
PBX1 pre-B-cell leukemia homeobox 1 -0.0217356
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0214414
PDE10A phosphodiesterase 10A -0.0213304
TTC28 tetratricopeptide repeat domain 28 -0.0212777
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0208084
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0206423
AUTS2 autism susceptibility candidate 2 -0.0203123
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0200647
UNC5D unc-5 homolog D (C. elegans) -0.0199456
RPS24 ribosomal protein S24 -0.0194309
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0192244
PRSS23 protease, serine, 23 -0.0187877
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0178936
RANBP17 RAN binding protein 17 -0.017739
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0175077
TPT1 tumor protein, translationally-controlled 1 -0.0172247
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0165079
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0162239
AEBP2 AE binding protein 2 -0.0156317
NCAM2 neural cell adhesion molecule 2 -0.0155231
PCDH9 protocadherin 9 -0.0151224
RBM47 RNA binding motif protein 47 -0.0147339
FSTL4 follistatin-like 4 -0.0146985
SLC16A6 solute carrier family 16, member 6 -0.014516
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0139585
GRB10 growth factor receptor-bound protein 10 -0.0138398
FOXC1 forkhead box C1 -0.0136253
THSD4 thrombospondin, type I, domain containing 4 -0.013558
PDE1A phosphodiesterase 1A, calmodulin-dependent -0.0134782
AOPEP aminopeptidase O (putative) -0.0133379
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0132819
PRKN parkin RBR E3 ubiquitin protein ligase -0.013242
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0130413
CTSD cathepsin D -0.013024
ZBTB20 zinc finger and BTB domain containing 20 -0.0130189
CUX1 cut-like homeobox 1 -0.0126461
TBC1D19 TBC1 domain family, member 19 -0.0126119
DNAH14 dynein, axonemal, heavy chain 14 -0.0124539
THSD7A thrombospondin, type I, domain containing 7A -0.0124364
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0123958
GNS glucosamine (N-acetyl)-6-sulfatase -0.012238
ENOSF1 enolase superfamily member 1 -0.012182
TCF12 transcription factor 12 -0.0120618
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0118076
RTN1 reticulon 1 -0.011655
RPL9 ribosomal protein L9 -0.0115824
LAMA5 laminin, alpha 5 -0.0114564
CDH19 cadherin 19, type 2 -0.0112816
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -0.0111118
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.0106594
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0105013
SVIL supervillin -0.0104608
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.010355
PDE7B phosphodiesterase 7B -0.0102503
MAML2 mastermind-like 2 (Drosophila) -0.0101825
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0101354
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.00989853
ADGRB3 adhesion G protein-coupled receptor B3 -0.00983147
DNAH11 dynein, axonemal, heavy chain 11 -0.00979921
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0095557
SAR1A secretion associated, Ras related GTPase 1A -0.00953948
OSMR oncostatin M receptor -0.00928203
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0092727
EPHA5 EPH receptor A5 -0.0092212
VDAC1 voltage-dependent anion channel 1 -0.00906871
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.00900986
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.00883674
RPH3AL rabphilin 3A-like (without C2 domains) -0.00880322
RHOH ras homolog family member H -0.00878091
CDK17 cyclin-dependent kinase 17 -0.0086207
ZNF407 zinc finger protein 407 -0.00856726
S100A6 S100 calcium binding protein A6 -0.00856327
IER3 immediate early response 3 -0.00844328
ITGB8 integrin, beta 8 -0.00835983
STX8 syntaxin 8 -0.00821119
ZMYND8 zinc finger, MYND-type containing 8 -0.00814587