Pasireotide (acetate)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.206287
SFTPA2 surfactant protein A2 0.116946
YBX1 Y box binding protein 1 0.110201
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.104741
MT2A metallothionein 2A 0.099348
RPS12 ribosomal protein S12 0.0967505
RPS6 ribosomal protein S6 0.0926079
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0908597
MYH9 myosin, heavy chain 9, non-muscle 0.0875945
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.080104
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0756411
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0748698
MKI67 marker of proliferation Ki-67 0.0725917
CENPF centromere protein F, 350/400kDa 0.0720137
RPS3 ribosomal protein S3 0.0695373
ZFP36 ZFP36 ring finger protein 0.0643322
RPS8 ribosomal protein S8 0.064301
RPS2 ribosomal protein S2 0.0619512
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0604162
KTN1 kinectin 1 (kinesin receptor) 0.0598382
TPM3 tropomyosin 3 0.0594217
RPLP2 ribosomal protein, large, P2 0.0585631
APLP2 amyloid beta (A4) precursor-like protein 2 0.0581881
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0570125
ANKRD11 ankyrin repeat domain 11 0.0569579
SAMD4B sterile alpha motif domain containing 4B 0.0563539
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0551073
RPL23 ribosomal protein L23 0.0530236
EEF1G eukaryotic translation elongation factor 1 gamma 0.0514735
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.05133
RPS17 ribosomal protein S17 0.0511328
RPS19 ribosomal protein S19 0.0505373
RPL3 ribosomal protein L3 0.0490924
HSPA8 heat shock 70kDa protein 8 0.0482816
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.047428
RPL37A ribosomal protein L37a 0.0467139
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0448608
ASPH aspartate beta-hydroxylase 0.0444921
GOLGB1 golgin B1 0.0442066
GOLGA4 golgin A4 0.0437424
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0420151
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0392448
RPL12 ribosomal protein L12 0.0382663
RPL21 ribosomal protein L21 0.0375512
MSN moesin 0.0372678
RPL11 ribosomal protein L11 0.0369933
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.036845
TPX2 TPX2, microtubule-associated 0.0355665
RPL36 ribosomal protein L36 0.0353776
NFE2L1 nuclear factor, erythroid 2-like 1 0.0345288
BRD2 bromodomain containing 2 0.0344481
INTS6 integrator complex subunit 6 0.0337861
B2M beta-2-microglobulin 0.0332665
RPS23 ribosomal protein S23 0.0327568
RRM2 ribonucleotide reductase M2 0.0324738
ARHGAP29 Rho GTPase activating protein 29 0.0324137
GARS1 glycyl-tRNA synthetase 1 0.0322288
RPL26 ribosomal protein L26 0.0321943
EIF4B eukaryotic translation initiation factor 4B 0.0320947
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0318156
RPS4X ribosomal protein S4, X-linked 0.0316996
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0313452
EIF5B eukaryotic translation initiation factor 5B 0.0313145
WWTR1 WW domain containing transcription regulator 1 0.031106
FXR1 fragile X mental retardation, autosomal homolog 1 0.0303323
CKAP5 cytoskeleton associated protein 5 0.0303244
ZCCHC7 zinc finger, CCHC domain containing 7 0.0300442
YBX3 Y box binding protein 3 0.0299661
DSCAM Down syndrome cell adhesion molecule 0.0293115
RPL19 ribosomal protein L19 0.029218
DST dystonin 0.0291579
PRRC2C proline-rich coiled-coil 2C 0.0291143
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0285622
RPL32 ribosomal protein L32 0.0276481
FNDC3B fibronectin type III domain containing 3B 0.0273749
DNMBP dynamin binding protein 0.0268894
CCDC88A coiled-coil domain containing 88A 0.0267554
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0267357
VEGFA vascular endothelial growth factor A 0.0266758
ZNF146 zinc finger protein 146 0.0264289
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0258998
VMP1 vacuole membrane protein 1 0.0256035
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0255201
PNISR PNN-interacting serine/arginine-rich protein 0.0252989
SMAD3 SMAD family member 3 0.0252881
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0252781
SRRM1 serine/arginine repetitive matrix 1 0.0251054
RPL8 ribosomal protein L8 0.0250991
RSF1 remodeling and spacing factor 1 0.025041
SMYD3 SET and MYND domain containing 3 0.0250248
SON SON DNA binding protein 0.0249706
SET SET nuclear proto-oncogene 0.024942
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0248855
AHNAK AHNAK nucleoprotein 0.0247555
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0247093
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0245696
OGA O-GlcNAcase 0.0243931
RPL28 ribosomal protein L28 0.0242993
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.024266
ACTN4 actinin, alpha 4 0.0242015

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.311768
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119088
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.102516
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0987845
PTMA prothymosin, alpha -0.0975077
RPS16 ribosomal protein S16 -0.087521
ACTG1 actin gamma 1 -0.0813892
CTSD cathepsin D -0.064403
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0599007
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0577659
TMEM123 transmembrane protein 123 -0.0575791
KPNB1 karyopherin (importin) beta 1 -0.0546915
TRIO trio Rho guanine nucleotide exchange factor -0.0508662
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0488363
S100A6 S100 calcium binding protein A6 -0.0467033
HSPG2 heparan sulfate proteoglycan 2 -0.0461671
RPLP0 ribosomal protein, large, P0 -0.0432144
ANXA2 annexin A2 -0.0429486
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0429313
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0423833
VDAC1 voltage-dependent anion channel 1 -0.0413417
LOC112694756 uncharaterized LOC112694756 -0.0400976
RPS24 ribosomal protein S24 -0.0400421
SLC35F3 solute carrier family 35, member F3 -0.0376289
RNF220 ring finger protein 220 -0.0368572
CD44 CD44 molecule (Indian blood group) -0.0360548
LDHA lactate dehydrogenase A -0.0357199
CD109 CD109 molecule -0.0335228
MYOF myoferlin -0.0327325
ATG7 autophagy related 7 -0.0310578
DIAPH2 diaphanous-related formin 2 -0.0307179
EGFR epidermal growth factor receptor -0.0306726
HMGA1 high mobility group AT-hook 1 -0.0304252
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0303655
TUBB tubulin, beta class I -0.0291309
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0290336
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0289984
FTL ferritin, light polypeptide -0.0289153
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0282999
HMGA2 high mobility group AT-hook 2 -0.0281168
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0270113
AFAP1 actin filament associated protein 1 -0.0269732
RAP1B RAP1B, member of RAS oncogene family -0.0265719
RIGI RNA sensor RIG-I -0.0255487
PPARG peroxisome proliferator-activated receptor gamma -0.025111
PGK1 phosphoglycerate kinase 1 -0.0251005
ZMYND8 zinc finger, MYND-type containing 8 -0.0248236
TM4SF1 transmembrane 4 L six family member 1 -0.0244656
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0228888
RASAL2 RAS protein activator like 2 -0.0227109
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.022574
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0223842
ODF2L outer dense fiber of sperm tails 2-like -0.022259
VCL vinculin -0.0219808
NF1 neurofibromin 1 -0.0218774
EXT1 exostosin glycosyltransferase 1 -0.0218494
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0218425
MYADM myeloid-associated differentiation marker -0.0218394
EHBP1 EH domain binding protein 1 -0.0216686
IARS1 isoleucyl-tRNA synthetase 1 -0.021599
MEF2A myocyte enhancer factor 2A -0.021577
RAB7A RAB7A, member RAS oncogene family -0.0214633
RPL27A ribosomal protein L27a -0.0213982
LMNA lamin A/C -0.0212764
CAVIN1 caveolae associated protein 1 -0.0207276
KDM3A lysine (K)-specific demethylase 3A -0.0206832
REEP3 receptor accessory protein 3 -0.0204712
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0201929
SDK1 sidekick cell adhesion molecule 1 -0.0201846
RPL39 ribosomal protein L39 -0.0197075
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0194026
NHSL1 NHS-like 1 -0.0192989
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0192633
FHL2 four and a half LIM domains 2 -0.0192258
ENO1 enolase 1, (alpha) -0.0191377
CD164 CD164 molecule, sialomucin -0.0190272
ARHGAP26 Rho GTPase activating protein 26 -0.019012
BMAL2 basic helix-loop-helix ARNT like 2 -0.0188879
ELL2 elongation factor, RNA polymerase II, 2 -0.0188302
H1-0 H1.0 linker histone -0.0188115
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0188037
CD59 CD59 molecule, complement regulatory protein -0.0187359
CCND1 cyclin D1 -0.018734
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0185981
THSD4 thrombospondin, type I, domain containing 4 -0.0184578
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0183197
FBXO17 F-box protein 17 -0.0182484
ABLIM1 actin binding LIM protein 1 -0.0180378
MYO1E myosin IE -0.0180268
ARF1 ADP-ribosylation factor 1 -0.0179421
KRT19 keratin 19, type I -0.0178816
NPAS2 neuronal PAS domain protein 2 -0.0178377
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0176075
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0176024
TNS3 tensin 3 -0.0175981
SBF2 SET binding factor 2 -0.015937
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0156254
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0153796
PRSS23 protease, serine, 23 -0.015103
BIRC3 baculoviral IAP repeat containing 3 -0.0150887