Pasireotide (acetate)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.115783
MYH9 myosin, heavy chain 9, non-muscle 0.11341
FN1 fibronectin 1 0.110735
MACF1 microtubule-actin crosslinking factor 1 0.0949577
TGFBI transforming growth factor, beta-induced, 68kDa 0.0914623
VCL vinculin 0.0907448
SOD2 superoxide dismutase 2, mitochondrial 0.089511
CD44 CD44 molecule (Indian blood group) 0.0890265
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0868959
KYNU kynureninase 0.0784305
IGFBP3 insulin-like growth factor binding protein 3 0.0779566
NRXN3 neurexin 3 0.0733458
ASPH aspartate beta-hydroxylase 0.0667341
VEGFC vascular endothelial growth factor C 0.0649836
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0618842
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0601836
VEGFA vascular endothelial growth factor A 0.0569879
FNDC3B fibronectin type III domain containing 3B 0.0542003
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0524849
ZSWIM6 zinc finger, SWIM-type containing 6 0.052153
PRELID2 PRELI domain containing 2 0.0496495
CDK6 cyclin-dependent kinase 6 0.048428
MBD5 methyl-CpG binding domain protein 5 0.046914
VMP1 vacuole membrane protein 1 0.0450924
INTS6 integrator complex subunit 6 0.0450574
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0450078
ATXN1 ataxin 1 0.0434684
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0433514
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0432542
UBC ubiquitin C 0.0431934
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0431472
PDLIM5 PDZ and LIM domain 5 0.0426226
SAMD4A sterile alpha motif domain containing 4A 0.0425875
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0417908
ITGAV integrin, alpha V 0.0407851
HIP1 huntingtin interacting protein 1 0.0394321
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0388863
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0388244
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.038818
ARHGAP24 Rho GTPase activating protein 24 0.0387329
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0387209
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0386718
DST dystonin 0.0385093
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0379218
HMGA2 high mobility group AT-hook 2 0.0371018
AHNAK AHNAK nucleoprotein 0.0371009
THBS1 thrombospondin 1 0.0363402
SEC24A SEC24 family member A 0.0348091
ANKRD11 ankyrin repeat domain 11 0.0347198
GOLGB1 golgin B1 0.0346438
PSD3 pleckstrin and Sec7 domain containing 3 0.0343808
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0341209
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0340812
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.033753
CLIP2 CAP-GLY domain containing linker protein 2 0.0336534
DSCAM Down syndrome cell adhesion molecule 0.0333307
FBXL7 F-box and leucine-rich repeat protein 7 0.0331786
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0323619
CTNND1 catenin (cadherin-associated protein), delta 1 0.0317451
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0313859
MCL1 myeloid cell leukemia 1 0.0313761
BBS9 Bardet-Biedl syndrome 9 0.031321
AKAP9 A kinase (PRKA) anchor protein 9 0.0311945
ZNF644 zinc finger protein 644 0.0311913
PTK2 protein tyrosine kinase 2 0.0301779
GSE1 Gse1 coiled-coil protein 0.0300523
COL4A1 collagen, type IV, alpha 1 0.0298067
BCLAF1 BCL2-associated transcription factor 1 0.0297166
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.029639
TPM3 tropomyosin 3 0.0295379
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0295257
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0294261
TLN1 talin 1 0.029158
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0289601
FAF1 Fas (TNFRSF6) associated factor 1 0.0288742
DNAH11 dynein, axonemal, heavy chain 11 0.0284462
TTC3 tetratricopeptide repeat domain 3 0.0284075
SETBP1 SET binding protein 1 0.0279979
SBF2 SET binding factor 2 0.0279282
SND1 staphylococcal nuclease and tudor domain containing 1 0.0279049
TIMP3 TIMP metallopeptidase inhibitor 3 0.0278478
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0277571
FAM13A family with sequence similarity 13, member A 0.0276753
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0276524
LIMS1 LIM and senescent cell antigen-like domains 1 0.0276494
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0274324
PTPRM protein tyrosine phosphatase, receptor type, M 0.0272086
SCFD1 sec1 family domain containing 1 0.0271297
ZCCHC7 zinc finger, CCHC domain containing 7 0.0270453
EXT1 exostosin glycosyltransferase 1 0.0269763
MYO9A myosin IXA 0.0267747
ZMIZ1 zinc finger, MIZ-type containing 1 0.0267088
AEBP2 AE binding protein 2 0.0266437
HSPA8 heat shock 70kDa protein 8 0.0265456
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0263692
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0262422
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0261984
PITPNB phosphatidylinositol transfer protein, beta 0.0257639
ARB2A ARB2 cotranscriptional regulator A 0.0255215
TAOK1 TAO kinase 1 0.0255091

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.107305
MT2A metallothionein 2A -0.093211
FTL ferritin, light polypeptide -0.0842233
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.082869
HLA-B major histocompatibility complex, class I, B -0.0770273
NAMPT nicotinamide phosphoribosyltransferase -0.0718758
F3 coagulation factor III (thromboplastin, tissue factor) -0.0591432
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0544165
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0472763
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0430645
MT1X metallothionein 1X -0.042534
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0421564
ZMYND8 zinc finger, MYND-type containing 8 -0.0389737
ACTG1 actin gamma 1 -0.0382284
RPLP1 ribosomal protein, large, P1 -0.0371754
PDIA3 protein disulfide isomerase family A, member 3 -0.0361257
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0343867
CAVIN1 caveolae associated protein 1 -0.0332508
USP34 ubiquitin specific peptidase 34 -0.0326391
CCNI cyclin I -0.0326208
RPS14 ribosomal protein S14 -0.0316744
AK1 adenylate kinase 1 -0.031503
CALR calreticulin -0.0310427
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0306928
GNAS GNAS complex locus -0.0300515
PTN pleiotrophin -0.0299529
TPX2 TPX2, microtubule-associated -0.0299321
RLF rearranged L-myc fusion -0.029585
COL1A1 collagen, type I, alpha 1 -0.0291161
H3-3B H3.3 histone B -0.0288927
FOXP1 forkhead box P1 -0.0283914
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0280516
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0279502
RPL34 ribosomal protein L34 -0.02762
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0275101
CRLS1 cardiolipin synthase 1 -0.0271028
IFI6 interferon, alpha-inducible protein 6 -0.0269684
LOC112694756 uncharaterized LOC112694756 -0.026829
HLA-C major histocompatibility complex, class I, C -0.0267243
STC1 stanniocalcin 1 -0.0266376
TUBA1B tubulin, alpha 1b -0.0264925
IARS1 isoleucyl-tRNA synthetase 1 -0.0264331
RPL28 ribosomal protein L28 -0.0255369
NPAS2 neuronal PAS domain protein 2 -0.0252643
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.025111
TENT5A terminal nucleotidyltransferase 5A -0.0251051
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0249067
COL1A2 collagen, type I, alpha 2 -0.0248049
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0246222
NDFIP1 Nedd4 family interacting protein 1 -0.0245026
UBE2C ubiquitin-conjugating enzyme E2C -0.0244194
EFHD2 EF-hand domain family, member D2 -0.0244104
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0243033
ATL1 atlastin GTPase 1 -0.0240959
S100A6 S100 calcium binding protein A6 -0.0239568
HMGB1 high mobility group box 1 -0.0239194
FNBP4 formin binding protein 4 -0.0237034
STK17A serine/threonine kinase 17a -0.0236748
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0236261
EIF3D eukaryotic translation initiation factor 3, subunit D -0.0234207
ANKRD33B ankyrin repeat domain 33B -0.0232814
SKAP2 src kinase associated phosphoprotein 2 -0.0231553
INHBA inhibin, beta A -0.0229892
MYADM myeloid-associated differentiation marker -0.0228056
VDAC1 voltage-dependent anion channel 1 -0.0227187
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0226757
CENPE centromere protein E, 312kDa -0.0224631
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0223819
MMP2 matrix metallopeptidase 2 -0.0222552
RAB1A RAB1A, member RAS oncogene family -0.0220978
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0220669
ADM adrenomedullin -0.0219532
NOP58 NOP58 ribonucleoprotein -0.0219119
DDIT4 DNA-damage-inducible transcript 4 -0.0218655
MANF mesencephalic astrocyte-derived neurotrophic factor -0.0218216
EHD2 EH-domain containing 2 -0.0217698
RPL27A ribosomal protein L27a -0.0217523
HLA-E major histocompatibility complex, class I, E -0.0215863
SLC38A1 solute carrier family 38, member 1 -0.0215654
TMSB10 thymosin beta 10 -0.0215526
HDLBP high density lipoprotein binding protein -0.0214953
HMGB2 high mobility group box 2 -0.02147
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0213471
MX2 MX dynamin-like GTPase 2 -0.0209238
PNISR PNN-interacting serine/arginine-rich protein -0.0207588
TUBA1C tubulin, alpha 1c -0.0207038
COL6A1 collagen, type VI, alpha 1 -0.0205662
CDCA2 cell division cycle associated 2 -0.0205587
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0205298
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0204289
PTPRF protein tyrosine phosphatase, receptor type, F -0.0203152
CDH13 cadherin 13 -0.0202498
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0201793
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -0.020041
ERLEC1 endoplasmic reticulum lectin 1 -0.0200152
NF1 neurofibromin 1 -0.0198885
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0197095
SEPTIN7 septin 7 -0.0196188
TCF25 transcription factor 25 (basic helix-loop-helix) -0.019568
PTGR1 prostaglandin reductase 1 -0.0195057