Pasireotide (acetate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) 0.145324
FNDC3B fibronectin type III domain containing 3B 0.143656
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.118429
DST dystonin 0.0914799
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0885099
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0878134
MACF1 microtubule-actin crosslinking factor 1 0.0842549
FMNL2 formin-like 2 0.082486
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0798276
BIRC3 baculoviral IAP repeat containing 3 0.0752747
SVIL supervillin 0.0682645
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0659841
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0655552
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0638556
AKAP12 A kinase (PRKA) anchor protein 12 0.0625899
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0596513
SLC38A2 solute carrier family 38, member 2 0.0585725
AHNAK AHNAK nucleoprotein 0.0573494
ANO6 anoctamin 6 0.0571062
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0550304
NT5E 5'-nucleotidase, ecto (CD73) 0.0525881
ZBTB20 zinc finger and BTB domain containing 20 0.0518837
ANGPTL4 angiopoietin-like 4 0.0508378
SAMD4A sterile alpha motif domain containing 4A 0.0501696
TRIO trio Rho guanine nucleotide exchange factor 0.0476828
OSMR oncostatin M receptor 0.047582
RIGI RNA sensor RIG-I 0.0474051
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0473677
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0468217
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0465471
SDC4 syndecan 4 0.0449306
HMGA2 high mobility group AT-hook 2 0.0444074
BASP1 brain abundant, membrane attached signal protein 1 0.0438831
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0434833
SH3KBP1 SH3-domain kinase binding protein 1 0.0433063
SMAD3 SMAD family member 3 0.0418938
NAV2 neuron navigator 2 0.0416734
LDHA lactate dehydrogenase A 0.0416034
BCAR3 breast cancer anti-estrogen resistance 3 0.0415204
VMP1 vacuole membrane protein 1 0.0412642
ASPH aspartate beta-hydroxylase 0.0404469
TM4SF1 transmembrane 4 L six family member 1 0.0395934
TPT1 tumor protein, translationally-controlled 1 0.0389413
ATXN1 ataxin 1 0.038517
EFNA5 ephrin-A5 0.037995
ENO1 enolase 1, (alpha) 0.0374822
RAD51B RAD51 paralog B 0.0370249
SMYD3 SET and MYND domain containing 3 0.0369015
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0363927
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0361024
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0360531
PTK2 protein tyrosine kinase 2 0.0357218
RASAL2 RAS protein activator like 2 0.0351133
AKAP13 A kinase (PRKA) anchor protein 13 0.0345944
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0345526
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0338577
BICD1 bicaudal D homolog 1 (Drosophila) 0.0337199
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0327862
B2M beta-2-microglobulin 0.0326874
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0326211
MBNL1 muscleblind-like splicing regulator 1 0.0325963
VIM vimentin 0.032397
PRSS23 protease, serine, 23 0.0320648
FMN1 formin 1 0.031957
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0318119
RTN4 reticulon 4 0.0316498
LPP LIM domain containing preferred translocation partner in lipoma 0.0312786
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.031225
ELL2 elongation factor, RNA polymerase II, 2 0.0309137
NALCN sodium leak channel, non selective 0.030755
RAI14 retinoic acid induced 14 0.0306177
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0299259
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0298324
ERBIN erbb2 interacting protein 0.0294647
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0286279
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0285617
YBX3 Y box binding protein 3 0.0282846
SASH1 SAM and SH3 domain containing 1 0.0282134
RPS6 ribosomal protein S6 0.0281556
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0281155
PCCA propionyl CoA carboxylase, alpha polypeptide 0.028008
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0279193
JMJD1C jumonji domain containing 1C 0.0279036
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0278861
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0275106
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0271918
MYH9 myosin, heavy chain 9, non-muscle 0.0269948
SOS1 son of sevenless homolog 1 (Drosophila) 0.0268773
ZMYND8 zinc finger, MYND-type containing 8 0.0268211
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0267496
FAM3C family with sequence similarity 3, member C 0.0267472
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.026651
HPCAL1 hippocalcin-like 1 0.0264295
DSCAM Down syndrome cell adhesion molecule 0.0262222
FER fer (fps/fes related) tyrosine kinase 0.0261727
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0261704
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0258178
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.025659
SLC35F2 solute carrier family 35, member F2 0.0254001
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0253396

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0538614
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0535025
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0529826
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0459907
NUP58 nucleoporin 58 -0.0393835
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.036668
WDR45B WD repeat domain 45B -0.0336734
IARS1 isoleucyl-tRNA synthetase 1 -0.0324229
HILPDA hypoxia inducible lipid droplet-associated -0.0319411
INTS6 integrator complex subunit 6 -0.031435
SNX14 sorting nexin 14 -0.0302335
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0300521
RPLP1 ribosomal protein, large, P1 -0.0294835
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0293926
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.029378
RPL35A ribosomal protein L35a -0.0281359
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0271579
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0242417
COPB1 coatomer protein complex, subunit beta 1 -0.0233841
SEC24A SEC24 family member A -0.0233702
CANX calnexin -0.0222704
MORF4L2 mortality factor 4 like 2 -0.022029
HM13 histocompatibility (minor) 13 -0.0217329
BSG basigin (Ok blood group) -0.0213086
RPL28 ribosomal protein L28 -0.0212235
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0209723
ZBTB43 zinc finger and BTB domain containing 43 -0.0209362
RPL23 ribosomal protein L23 -0.0208562
SRSF11 serine/arginine-rich splicing factor 11 -0.0206882
TPX2 TPX2, microtubule-associated -0.0205112
EIF1 eukaryotic translation initiation factor 1 -0.0203857
WAC WW domain containing adaptor with coiled-coil -0.0203536
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 -0.020343
NSD2 nuclear receptor binding SET domain protein 2 -0.0199
HOMER1 homer scaffolding protein 1 -0.0198081
MIS18BP1 MIS18 binding protein 1 -0.0196341
PGM3 phosphoglucomutase 3 -0.019437
RNF111 ring finger protein 111 -0.0193134
MIDEAS mitotic deacetylase associated SANT domain protein -0.0189629
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0188772
SEPTIN7 septin 7 -0.0187591
RPLP0 ribosomal protein, large, P0 -0.0185234
TTK TTK protein kinase -0.0184848
ANLN anillin, actin binding protein -0.018483
FOXO3 forkhead box O3 -0.0182081
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0181905
HELZ helicase with zinc finger -0.0180717
SGO2 shugoshin 2 -0.0178518
KDM3A lysine (K)-specific demethylase 3A -0.0175438
TNPO1 transportin 1 -0.017538
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0175168
HDLBP high density lipoprotein binding protein -0.0174371
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0174098
UBXN7 UBX domain protein 7 -0.0171632
INSIG1 insulin induced gene 1 -0.0170069
TFG TRK-fused gene -0.0168808
RAB1A RAB1A, member RAS oncogene family -0.0168375
TFRC transferrin receptor -0.016604
XPO6 exportin 6 -0.0163944
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0163662
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0163591
COPA coatomer protein complex, subunit alpha -0.0162051
COG5 component of oligomeric golgi complex 5 -0.0161506
TRA2B transformer 2 beta homolog (Drosophila) -0.0161245
MCTP1 multiple C2 domains, transmembrane 1 -0.0160766
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0160432
UBE2O ubiquitin-conjugating enzyme E2O -0.0160276
HMGB2 high mobility group box 2 -0.0160259
ZNF292 zinc finger protein 292 -0.0158871
SEC24D SEC24 family member D -0.0158003
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.0157496
CCDC47 coiled-coil domain containing 47 -0.0155863
RPS23 ribosomal protein S23 -0.0155588
GOLGA2 golgin A2 -0.015405
ADIPOR2 adiponectin receptor 2 -0.0153749
RPS19 ribosomal protein S19 -0.0152881
TP53 tumor protein p53 -0.0151017
MTDH metadherin -0.0148092
TRA2A transformer 2 alpha homolog (Drosophila) -0.0148027
MTF2 metal response element binding transcription factor 2 -0.0147608
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -0.0147398
COG6 component of oligomeric golgi complex 6 -0.0147236
TMEM263 transmembrane protein 263 -0.0147142
ETF1 eukaryotic translation termination factor 1 -0.0146903
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0146836
SLF1 SMC5-SMC6 complex localization factor 1 -0.0146348
AKAP10 A kinase (PRKA) anchor protein 10 -0.0146236
SMC4 structural maintenance of chromosomes 4 -0.0146041
ERLEC1 endoplasmic reticulum lectin 1 -0.0145984
LMAN1 lectin, mannose-binding, 1 -0.0145591
TCERG1 transcription elongation regulator 1 -0.0144435
GNAS GNAS complex locus -0.0144091
ANKRD37 ankyrin repeat domain 37 -0.014393
ARF4 ADP-ribosylation factor 4 -0.0143832
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0142812
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0142802
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 -0.0142298
ZNF207 zinc finger protein 207 -0.0142292
APOLD1 apolipoprotein L domain containing 1 -0.0141688
CALU calumenin -0.0141285