Pasireotide (acetate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pasireotide (acetate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pasireotide (acetate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.152857
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.126697
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.110019
HSPA8 heat shock 70kDa protein 8 0.0987758
RCOR1 REST corepressor 1 0.0986838
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.092333
EGFR epidermal growth factor receptor 0.0877855
RPS12 ribosomal protein S12 0.0857974
ATXN1 ataxin 1 0.0795246
RPL3 ribosomal protein L3 0.0767949
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0695042
CENPF centromere protein F, 350/400kDa 0.0653977
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0650786
SEPTIN9 septin 9 0.0634535
AREG amphiregulin 0.0627206
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.06177
NCEH1 neutral cholesterol ester hydrolase 1 0.05966
VCL vinculin 0.0587654
FHL2 four and a half LIM domains 2 0.0572012
LAMA4 laminin, alpha 4 0.0529605
RPS8 ribosomal protein S8 0.0523426
EEF1G eukaryotic translation elongation factor 1 gamma 0.051382
RPS19 ribosomal protein S19 0.0505305
DSPP dentin sialophosphoprotein 0.0503988
RPS2 ribosomal protein S2 0.050122
EGR1 early growth response 1 0.0480574
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0476765
CPOX coproporphyrinogen oxidase 0.0475307
AKAP9 A kinase (PRKA) anchor protein 9 0.0465654
YAP1 Yes-associated protein 1 0.0462903
ITGA6 integrin, alpha 6 0.0462838
YBX1 Y box binding protein 1 0.0460797
KTN1 kinectin 1 (kinesin receptor) 0.0455332
ZSWIM6 zinc finger, SWIM-type containing 6 0.0453313
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0448131
EMP1 epithelial membrane protein 1 0.044031
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0436299
SGMS2 sphingomyelin synthase 2 0.0436002
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.043168
RPS4X ribosomal protein S4, X-linked 0.0416771
MYH9 myosin, heavy chain 9, non-muscle 0.0416616
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0410982
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0402895
SMAD3 SMAD family member 3 0.039516
RPS3 ribosomal protein S3 0.0393827
RPL19 ribosomal protein L19 0.0379028
FAT1 FAT atypical cadherin 1 0.0377777
MACF1 microtubule-actin crosslinking factor 1 0.0377555
ASPH aspartate beta-hydroxylase 0.0374639
NUP50 nucleoporin 50kDa 0.0363352
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0361735
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0357537
APLP2 amyloid beta (A4) precursor-like protein 2 0.0355155
AKAP13 A kinase (PRKA) anchor protein 13 0.0352996
MKI67 marker of proliferation Ki-67 0.0349871
DOCK5 dedicator of cytokinesis 5 0.0346728
NTSR1 neurotensin receptor 1 (high affinity) 0.0343817
AHNAK AHNAK nucleoprotein 0.0340981
SFPQ splicing factor proline/glutamine-rich 0.0340738
ABR active BCR-related 0.0337995
ITPRID2 ITPR interacting domain containing 2 0.033654
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0333755
AKAP12 A kinase (PRKA) anchor protein 12 0.0333241
RPL21 ribosomal protein L21 0.0331233
BRD2 bromodomain containing 2 0.0326418
GATAD2A GATA zinc finger domain containing 2A 0.0323598
JARID2 jumonji, AT rich interactive domain 2 0.0319032
MT2A metallothionein 2A 0.0315283
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0313311
RPL37A ribosomal protein L37a 0.031225
SNX9 sorting nexin 9 0.031041
TPM3 tropomyosin 3 0.0308772
DSCAM Down syndrome cell adhesion molecule 0.0308453
BCL2L1 BCL2-like 1 0.0308417
DUSP4 dual specificity phosphatase 4 0.030122
LOC102724023 ES1 protein homolog, mitochondrial 0.0300012
GOLGB1 golgin B1 0.0299814
MYO5B myosin VB 0.0296062
RPS17 ribosomal protein S17 0.0294805
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0292244
DST dystonin 0.0291894
VMP1 vacuole membrane protein 1 0.0291243
RPL32 ribosomal protein L32 0.0288642
POTEF POTE ankyrin domain family, member F 0.0287564
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0285291
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0283292
RPL11 ribosomal protein L11 0.0281457
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0281146
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0278689
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0276957
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0275497
EFNB2 ephrin-B2 0.0274115
MCL1 myeloid cell leukemia 1 0.0273217
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0272514
KIF1B kinesin family member 1B 0.0269564
RPL26 ribosomal protein L26 0.0266786
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0266334
SRRM1 serine/arginine repetitive matrix 1 0.0265308
SFTPA2 surfactant protein A2 0.0263204
GOLGA4 golgin A4 0.0261155

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.308592
CD36 CD36 molecule (thrombospondin receptor) -0.215053
FERMT1 fermitin family member 1 -0.119545
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.101224
PTMA prothymosin, alpha -0.0996892
IER3 immediate early response 3 -0.0939372
HDAC2 histone deacetylase 2 -0.0915539
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0822136
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0723179
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0655618
FHIT fragile histidine triad -0.0596437
RPS24 ribosomal protein S24 -0.0563326
RAD51B RAD51 paralog B -0.0542713
RUNX2 runt-related transcription factor 2 -0.0505919
IGFBP3 insulin-like growth factor binding protein 3 -0.0505391
ACTG1 actin gamma 1 -0.0503203
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0496056
KLF5 Kruppel-like factor 5 (intestinal) -0.0485453
OXR1 oxidation resistance 1 -0.0478783
AOPEP aminopeptidase O (putative) -0.0476675
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0475988
SERINC5 serine incorporator 5 -0.046948
S100A6 S100 calcium binding protein A6 -0.0436537
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0417364
OSBPL3 oxysterol binding protein-like 3 -0.0406396
ITGB4 integrin, beta 4 -0.0403996
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0396749
KPNB1 karyopherin (importin) beta 1 -0.0345121
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0341196
ESYT2 extended synaptotagmin-like protein 2 -0.0334028
HMGA2 high mobility group AT-hook 2 -0.033337
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0320422
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.031135
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0298631
RBM25 RNA binding motif protein 25 -0.0298397
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0297265
NPEPPS aminopeptidase puromycin sensitive -0.0292714
PARD3 par-3 family cell polarity regulator -0.0291014
RPL35A ribosomal protein L35a -0.0288254
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0285083
VDAC1 voltage-dependent anion channel 1 -0.0282987
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0280828
NFIA nuclear factor I/A -0.0271391
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0267863
RREB1 ras responsive element binding protein 1 -0.0261913
MBNL1 muscleblind-like splicing regulator 1 -0.0249787
NEMF nuclear export mediator factor -0.0249426
MTAP methylthioadenosine phosphorylase -0.0248127
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.024003
GNAT3 guanine nucleotide binding protein, alpha transducing 3 -0.0238822
KLK6 kallikrein-related peptidase 6 -0.0235994
KDM3A lysine (K)-specific demethylase 3A -0.0232036
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0231804
TOP1 topoisomerase (DNA) I -0.0229952
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0229201
SQSTM1 sequestosome 1 -0.0228764
ZBTB7C zinc finger and BTB domain containing 7C -0.0227966
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0226525
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0225545
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0224611
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0221131
ANKRD28 ankyrin repeat domain 28 -0.0220957
ANXA4 annexin A4 -0.0219566
TMEM123 transmembrane protein 123 -0.0219168
LMO7 LIM domain 7 -0.0219017
PATJ PATJ crumbs cell polarity complex component -0.0218984
ZMYM2 zinc finger, MYM-type 2 -0.0218663
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0218159
ANAPC5 anaphase promoting complex subunit 5 -0.0217516
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0216496
ARF1 ADP-ribosylation factor 1 -0.0215401
XPO7 exportin 7 -0.0215338
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0214794
KLK10 kallikrein-related peptidase 10 -0.0214132
USP3 ubiquitin specific peptidase 3 -0.0212726
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0211861
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma -0.0211601
TPT1 tumor protein, translationally-controlled 1 -0.0210095
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0209079
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0208694
PCNX1 pecanex 1 -0.0205878
ICA1 islet cell autoantigen 1, 69kDa -0.0205225
CLASP2 cytoplasmic linker associated protein 2 -0.0205011
PTBP2 polypyrimidine tract binding protein 2 -0.0204962
SREBF2 sterol regulatory element binding transcription factor 2 -0.0204381
LMAN1 lectin, mannose-binding, 1 -0.0204126
NEK7 NIMA-related kinase 7 -0.020139
IARS1 isoleucyl-tRNA synthetase 1 -0.0200722
S100A10 S100 calcium binding protein A10 -0.0199892
DIAPH2 diaphanous-related formin 2 -0.0198446
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0197612
STRN3 striatin, calmodulin binding protein 3 -0.0197487
NT5DC3 5'-nucleotidase domain containing 3 -0.0197462
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0195317
DDIT4 DNA-damage-inducible transcript 4 -0.0195181
CD2AP CD2-associated protein -0.0194052
LOC112694756 uncharaterized LOC112694756 -0.0194036
MARCHF6 membrane associated ring-CH-type finger 6 -0.0190739
BMP4 bone morphogenetic protein 4 -0.0189495
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0188788