Pazopanib Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/10113978
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Genes

199 proteins with high or low expression in Pazopanib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
FBXO41 F-box protein 41 2.89
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.01
NRP1 neuropilin 1 1.0
DNAH1 dynein, axonemal, heavy chain 1 0.95
SLFN5 schlafen family member 5 0.94
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.93
ABHD2 abhydrolase domain containing 2 0.89
FAM110C family with sequence similarity 110, member C 0.86
NIBAN1 niban apoptosis regulator 1 0.84
GDF15 growth differentiation factor 15 0.83
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 0.81
TRIB3 tribbles pseudokinase 3 0.8
IRF9 interferon regulatory factor 9 0.78
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.74
KLK6 kallikrein-related peptidase 6 0.72
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.69
CD63 CD63 molecule 0.67
SLC49A4 solute carrier family 49 member 4 0.64
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.63
ADSS1 adenylosuccinate synthase 1 0.59
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.58
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.58
APOB apolipoprotein B 0.57
LTBP3 latent transforming growth factor beta binding protein 3 0.57
SDHAF4 succinate dehydrogenase complex assembly factor 4 0.57
FBXL4 F-box and leucine-rich repeat protein 4 0.56
SOX13 SRY (sex determining region Y)-box 13 0.55
CABLES1 Cdk5 and Abl enzyme substrate 1 0.54
PLEKHN1 pleckstrin homology domain containing, family N member 1 0.54
FSTL1 follistatin-like 1 0.53
THSD4 thrombospondin, type I, domain containing 4 0.53
UPP1 uridine phosphorylase 1 0.52
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.52
NT5E 5'-nucleotidase, ecto (CD73) 0.52
RBKS ribokinase 0.52
TSPAN3 tetraspanin 3 0.52
DUSP4 dual specificity phosphatase 4 0.51
NDFIP1 Nedd4 family interacting protein 1 0.5
VWA5B2 von Willebrand factor A domain containing 5B2 0.5
TMEM87B transmembrane protein 87B 0.5
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.49
KIAA1191 KIAA1191 0.48
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.48
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.47
COA5 cytochrome c oxidase assembly factor 5 0.47
AARS alanyl-tRNA synthetase 0.47
PLEK pleckstrin 0.47
SLC16A6 solute carrier family 16, member 6 0.47
TACSTD2 tumor-associated calcium signal transducer 2 0.46
DHFR dihydrofolate reductase 0.46
LMBRD1 LMBR1 domain containing 1 0.46
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.46
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 0.46
TENT5A terminal nucleotidyltransferase 5A 0.46
MEGF8 multiple EGF-like-domains 8 0.45
PCDH1 protocadherin 1 0.45
MAN2C1 mannosidase, alpha, class 2C, member 1 0.45
ZC3H6 zinc finger CCCH-type containing 6 0.45
IFRD1 interferon-related developmental regulator 1 0.45
FHIT fragile histidine triad 0.45
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.45
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 0.44
IGFBP5 insulin-like growth factor binding protein 5 0.44
SH2D5 SH2 domain containing 5 0.44
RNF111 ring finger protein 111 0.44
ATP13A2 ATPase type 13A2 0.44
ZCCHC24 zinc finger, CCHC domain containing 24 0.44
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 0.43
ITGB4 integrin, beta 4 0.43
LRATD2 LRAT domain containing 2 0.43
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 0.43
MOSPD3 motile sperm domain containing 3 0.43
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.42
TMEM104 transmembrane protein 104 0.42
TMEM231 transmembrane protein 231 0.42
ALPK1 alpha-kinase 1 0.42
SRR serine racemase 0.41
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.41
STARD3NL STARD3 N-terminal like 0.41
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.41
EVL Enah/Vasp-like 0.41
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.41
TBC1D14 TBC1 domain family, member 14 0.4
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 0.4
NDRG1 N-myc downstream regulated 1 0.4
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.4
CTSH cathepsin H 0.4
ONECUT2 one cut homeobox 2 0.4
FBXL20 F-box and leucine-rich repeat protein 20 0.4
LAMC2 laminin, gamma 2 0.4
HYKK hydroxylysine kinase 0.4
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.4
ACSS2 acyl-CoA synthetase short-chain family member 2 0.39
CTBS chitobiase, di-N-acetyl- 0.39
DNASE2 deoxyribonuclease II, lysosomal 0.39
MED30 mediator complex subunit 30 0.39
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 0.39
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.39
HAL histidine ammonia-lyase 0.39
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.38

low expression

Symbol Name Standardized Value
E2F8 E2F transcription factor 8 -2.29
EPHA4 EPH receptor A4 -1.52
ZNF580 zinc finger protein 580 -1.09
LOXL2 lysyl oxidase-like 2 -1.09
FRS2 fibroblast growth factor receptor substrate 2 -0.97
KLHL23 kelch-like family member 23 -0.86
STK16 serine/threonine kinase 16 -0.82
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.81
ZRANB1 zinc finger, RAN-binding domain containing 1 -0.79
ODC1 ornithine decarboxylase 1 -0.78
ARID5B AT rich interactive domain 5B (MRF1-like) -0.76
SEC14L1 SEC14-like 1 (S. cerevisiae) -0.76
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit -0.76
AXIN2 axin 2 -0.75
BMT2 base methyltransferase of 25S rRNA 2 homolog -0.74
LRP6 low density lipoprotein receptor-related protein 6 -0.74
TRIB1 tribbles pseudokinase 1 -0.73
KLHL21 kelch-like family member 21 -0.7
JADE1 jade family PHD finger 1 -0.69
GPATCH3 G patch domain containing 3 -0.69
ZHX3 zinc fingers and homeoboxes 3 -0.68
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -0.68
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -0.65
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 -0.64
KLHL25 kelch-like family member 25 -0.64
CHURC1 churchill domain containing 1 -0.64
CDC6 cell division cycle 6 -0.63
PML promyelocytic leukemia -0.63
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 -0.62
IFIH1 interferon induced with helicase C domain 1 -0.61
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.6
KITLG KIT ligand -0.6
PTTG1 pituitary tumor-transforming 1 -0.6
ANKRD10 ankyrin repeat domain 10 -0.6
SMIM26 small integral membrane protein 26 -0.6
YBX3 Y box binding protein 3 -0.59
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -0.59
JUN jun proto-oncogene -0.59
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 -0.58
CDC45 cell division cycle 45 -0.56
ENO1 enolase 1, (alpha) -0.55
ZNF124 zinc finger protein 124 -0.52
RND3 Rho family GTPase 3 -0.52
PPP1R2B PPP1R2 family member B -0.52
PCLAF PCNA clamp associated factor -0.51
CEP55 centrosomal protein 55kDa -0.51
VASN vasorin -0.51
ZNF430 zinc finger protein 430 -0.5
ZNF600 zinc finger protein 600 -0.5
PRELID1 PRELI domain containing 1 -0.5
MT1E metallothionein 1E -0.5
SBNO2 strawberry notch homolog 2 (Drosophila) -0.5
MAST3 microtubule associated serine/threonine kinase 3 -0.5
BMP4 bone morphogenetic protein 4 -0.5
PER1 period circadian clock 1 -0.49
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.49
UBE2S ubiquitin-conjugating enzyme E2S -0.49
PDE4B phosphodiesterase 4B, cAMP-specific -0.48
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B -0.48
FIZ1 FLT3-interacting zinc finger 1 -0.48
PLK1 polo-like kinase 1 -0.47
IL10RB interleukin 10 receptor, beta -0.45
FAM111B family with sequence similarity 111, member B -0.45
GCH1 GTP cyclohydrolase 1 -0.45
DOCK11 dedicator of cytokinesis 11 -0.45
CDKN3 cyclin-dependent kinase inhibitor 3 -0.45
FAIM Fas apoptotic inhibitory molecule -0.45
FAM13A family with sequence similarity 13, member A -0.45
SCNM1 sodium channel modifier 1 -0.45
TOP2A topoisomerase (DNA) II alpha 170kDa -0.45
MID1IP1 MID1 interacting protein 1 -0.45
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.44
MTFR2 mitochondrial fission regulator 2 -0.44
ZBTB45 zinc finger and BTB domain containing 45 -0.44
PSRC1 proline/serine-rich coiled-coil 1 -0.44
INAVA innate immunity activator -0.44
TYMS thymidylate synthetase -0.44
SVBP small vasohibin binding protein -0.43
CPA4 carboxypeptidase A4 -0.43
CCDC138 coiled-coil domain containing 138 -0.43
ADCK5 aarF domain containing kinase 5 -0.43
CCDC84 coiled-coil domain containing 84 -0.42
SYTL3 synaptotagmin-like 3 -0.42
RAD54B RAD54 homolog B (S. cerevisiae) -0.42
C15ORF40 chromosome 15 open reading frame 40 -0.42
ANKRD26 ankyrin repeat domain 26 -0.42
CCNB1 cyclin B1 -0.42
TCP11L1 t-complex 11, testis-specific-like 1 -0.42
HOXB9 homeobox B9 -0.42
LIMK1 LIM domain kinase 1 -0.42
DEPDC1B DEP domain containing 1B -0.42
LATS2 large tumor suppressor kinase 2 -0.41
AAGAB alpha- and gamma-adaptin binding protein -0.41
MICA MHC class I polypeptide-related sequence A -0.41
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase -0.41
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit -0.41
KIAA0586 KIAA0586 -0.41
KIF1B kinesin family member 1B -0.41
RILPL2 Rab interacting lysosomal protein-like 2 -0.41