Pelvic Organ Prolapse Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Abnormal descent of a pelvic organ resulting in the protrusion of the organ beyond its normal anatomical confines. (Experimental Factor Ontology, EFO_0004710)
External Link https://www.disgenet.org/browser/0/1/0/C0877015
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Genes

111 genes associated with the disease Pelvic Organ Prolapse in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACTB actin, beta
ACTG1 actin gamma 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADRB3 adrenoceptor beta 3
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATF3 activating transcription factor 3
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BGN biglycan
BMP1 bone morphogenetic protein 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALD1 caldesmon 1
CAPG capping protein (actin filament), gelsolin-like
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCK cholecystokinin
CD46 CD46 molecule, complement regulatory protein
CDKN2A cyclin-dependent kinase inhibitor 2A
CHPT1 choline phosphotransferase 1
CNOT8 CCR4-NOT transcription complex, subunit 8
COL14A1 collagen, type XIV, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A1 collagen, type V, alpha 1
CORO7 coronin 7
CPE carboxypeptidase E
CRYM crystallin, mu
CS citrate synthase
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DCN decorin
DES desmin
DHDDS dehydrodolichyl diphosphate synthase
DPP6 dipeptidyl-peptidase 6
ECM1 extracellular matrix protein 1
EIF1 eukaryotic translation initiation factor 1
ELN elastin
EPHB2 EPH receptor B2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FBLN5 fibulin 5
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1
FLT4 fms-related tyrosine kinase 4
FMOD fibromodulin
FOXC1 forkhead box C1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GPX1 glutathione peroxidase 1
GUCA1C guanylate cyclase activator 1C
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOXA11 homeobox A11
IL6 interleukin 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KL klotho
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALS1 lectin, galactoside-binding, soluble, 1
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LOXL4 lysyl oxidase-like 4
LUM lumican
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MARK3 MAP/microtubule affinity-regulating kinase 3
MFN2 mitofusin 2
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MMRN1 multimerin 1
MSX2 msh homeobox 2
NFE2L1 nuclear factor, erythroid 2-like 1
NFE2L2 nuclear factor, erythroid 2-like 2
NKX2-3 NK2 homeobox 3
NRF1 nuclear respiratory factor 1
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PARP1 poly (ADP-ribose) polymerase 1
PGR progesterone receptor
PI3 peptidase inhibitor 3, skin-derived
PKD2L1 polycystic kidney disease 2-like 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POPDC2 popeye domain containing 2
POPDC3 popeye domain containing 3
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRSS3 protease, serine, 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRD protein tyrosine phosphatase, receptor type, D
PYDC2 pyrin domain containing 2
RXFP1 relaxin/insulin-like family peptide receptor 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHBG sex hormone-binding globulin
SLC19A1 solute carrier family 19 (folate transporter), member 1
SNAI2 snail family zinc finger 2
STAU2 staufen double-stranded RNA binding protein 2
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
TCF21 transcription factor 21
TFAM transcription factor A, mitochondrial
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TNXB tenascin XB
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
VIM vimentin
WNK1 WNK lysine deficient protein kinase 1
ZFAT zinc finger and AT hook domain containing