| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pemetrexed_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.189569 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.136758 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.085184 |
| FLNA | filamin A, alpha | 0.0814808 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0636442 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0607988 |
| FBN1 | fibrillin 1 | 0.0539548 |
| FLNB | filamin B, beta | 0.0489791 |
| L1CAM | L1 cell adhesion molecule | 0.04891 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0486798 |
| APP | amyloid beta (A4) precursor protein | 0.0484196 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0469638 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0467258 |
| SEPTIN9 | septin 9 | 0.0447154 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0443631 |
| COL3A1 | collagen, type III, alpha 1 | 0.0434334 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0425231 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0419767 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0405923 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0394981 |
| MSN | moesin | 0.0384604 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0380926 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0375266 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0368043 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0364295 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0347324 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0343357 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0334686 |
| VEGFA | vascular endothelial growth factor A | 0.0323948 |
| NAV2 | neuron navigator 2 | 0.0314214 |
| LOXL2 | lysyl oxidase-like 2 | 0.0311261 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0308935 |
| CD109 | CD109 molecule | 0.0304465 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.029676 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0296666 |
| ARRDC3 | arrestin domain containing 3 | 0.029516 |
| STC1 | stanniocalcin 1 | 0.0289378 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0288494 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0287634 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0279591 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0275681 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.026583 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0265142 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0263211 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0257016 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0253091 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0252652 |
| RNF24 | ring finger protein 24 | 0.0249473 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0247243 |
| VIM | vimentin | 0.0245669 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0244491 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0243761 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0243736 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0242951 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0242728 |
| SH3BP2 | SH3-domain binding protein 2 | 0.0242167 |
| SETD5 | SET domain containing 5 | 0.0241963 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0237658 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0222904 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0221842 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.021989 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0219282 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0218686 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0218403 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0216018 |
| AFDN | afadin, adherens junction formation factor | 0.0214486 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0213549 |
| HMGB2 | high mobility group box 2 | 0.0209633 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0208077 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0207701 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0204715 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0204653 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0203511 |
| UBQLN1 | ubiquilin 1 | 0.0202197 |
| CALR | calreticulin | 0.0201934 |
| SUCO | SUN domain containing ossification factor | 0.0198104 |
| OPTN | optineurin | 0.0194087 |
| RPS3 | ribosomal protein S3 | 0.019186 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0190589 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) | 0.0190572 |
| DENND5A | DENN/MADD domain containing 5A | 0.0188852 |
| KIF16B | kinesin family member 16B | 0.0188376 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0187599 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0186674 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0186581 |
| COL5A2 | collagen, type V, alpha 2 | 0.0184604 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0184431 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.018331 |
| SP3 | Sp3 transcription factor | 0.0180745 |
| WAC | WW domain containing adaptor with coiled-coil | 0.018038 |
| INSIG2 | insulin induced gene 2 | 0.0179595 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0178825 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0177697 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.0177486 |
| KRT18 | keratin 18, type I | 0.017732 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0173526 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0173044 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0172883 |
| AXL | AXL receptor tyrosine kinase | 0.0170758 |
| FERMT2 | fermitin family member 2 | 0.0170318 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.239109 |
| TMSB10 | thymosin beta 10 | -0.214994 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.133648 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.112085 |
| HLA-B | major histocompatibility complex, class I, B | -0.110097 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.10991 |
| S100A10 | S100 calcium binding protein A10 | -0.0956732 |
| CSTB | cystatin B (stefin B) | -0.0887103 |
| LOX | lysyl oxidase | -0.0875195 |
| NAV1 | neuron navigator 1 | -0.0812437 |
| CDH13 | cadherin 13 | -0.0812239 |
| MT2A | metallothionein 2A | -0.0800162 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0780371 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0750219 |
| LMNA | lamin A/C | -0.0658956 |
| S100A6 | S100 calcium binding protein A6 | -0.0638176 |
| AHNAK | AHNAK nucleoprotein | -0.0628973 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0536263 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0523974 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0519723 |
| CCND1 | cyclin D1 | -0.0502758 |
| HLA-C | major histocompatibility complex, class I, C | -0.0471558 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0455475 |
| ACTG1 | actin gamma 1 | -0.0454008 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0449548 |
| CD44 | CD44 molecule (Indian blood group) | -0.0448595 |
| SUCNR1 | succinate receptor 1 | -0.0444986 |
| SMYD3 | SET and MYND domain containing 3 | -0.043245 |
| RIGI | RNA sensor RIG-I | -0.0431544 |
| DST | dystonin | -0.0431369 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0429974 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.042987 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0428982 |
| MT1X | metallothionein 1X | -0.0417141 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0409788 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0399127 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.0394521 |
| MEIS2 | Meis homeobox 2 | -0.0393644 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0382421 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0381039 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0380232 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0375416 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0373937 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0369958 |
| RRBP1 | ribosome binding protein 1 | -0.0366297 |
| POTEF | POTE ankyrin domain family, member F | -0.0366058 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0361434 |
| MAP1B | microtubule-associated protein 1B | -0.0360491 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.03591 |
| CAVIN1 | caveolae associated protein 1 | -0.0357284 |
| CD99 | CD99 molecule | -0.0355699 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0355552 |
| TAGLN2 | transgelin 2 | -0.0355182 |
| PODXL | podocalyxin-like | -0.0351317 |
| RPL35A | ribosomal protein L35a | -0.0350476 |
| FUS | FUS RNA binding protein | -0.034936 |
| COL1A2 | collagen, type I, alpha 2 | -0.0349112 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0348874 |
| MX2 | MX dynamin-like GTPase 2 | -0.0341859 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0341389 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0339646 |
| S100A11 | S100 calcium binding protein A11 | -0.0333085 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0331761 |
| H3-3B | H3.3 histone B | -0.0331045 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0331011 |
| MAP4 | microtubule-associated protein 4 | -0.0330525 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0329699 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0327575 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0327342 |
| RPS15 | ribosomal protein S15 | -0.0327139 |
| RPLP2 | ribosomal protein, large, P2 | -0.0325321 |
| TBCA | tubulin folding cofactor A | -0.0306277 |
| GLG1 | golgi glycoprotein 1 | -0.0303319 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0299487 |
| CUX1 | cut-like homeobox 1 | -0.0297482 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0293198 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0292046 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0290797 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0290097 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0289087 |
| RPS6 | ribosomal protein S6 | -0.0288423 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0284247 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.028375 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0281855 |
| B2M | beta-2-microglobulin | -0.028161 |
| RPS21 | ribosomal protein S21 | -0.0277172 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0276709 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0275294 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.027409 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0273544 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0270648 |
| NDRG1 | N-myc downstream regulated 1 | -0.0270036 |
| BPTF | bromodomain PHD finger transcription factor | -0.0269978 |
| EHBP1 | EH domain binding protein 1 | -0.0269641 |
| TPR | translocated promoter region, nuclear basket protein | -0.0267926 |
| DCLK2 | doublecortin-like kinase 2 | -0.0267758 |
| FGF13 | fibroblast growth factor 13 | -0.0267318 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0265781 |
| RPS24 | ribosomal protein S24 | -0.0265158 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0264142 |
