| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pemetrexed_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.117597 |
| VIM | vimentin | 0.116759 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0678485 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0585756 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0508574 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0497192 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0469518 |
| XPO1 | exportin 1 | 0.0468431 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.042371 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0404307 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0390971 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0388972 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0381708 |
| PCBP2 | poly(rC) binding protein 2 | 0.0377076 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0376921 |
| MATR3 | matrin 3 | 0.0359887 |
| YBX1 | Y box binding protein 1 | 0.0346586 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0346107 |
| CPOX | coproporphyrinogen oxidase | 0.0345351 |
| CCNL1 | cyclin L1 | 0.0328724 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0321377 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0319965 |
| TXNRD1 | thioredoxin reductase 1 | 0.0309317 |
| TMEM41B | transmembrane protein 41B | 0.0306337 |
| ZNF292 | zinc finger protein 292 | 0.0296075 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0294219 |
| TNPO1 | transportin 1 | 0.0280392 |
| NEK7 | NIMA-related kinase 7 | 0.0279621 |
| PTMA | prothymosin, alpha | 0.027562 |
| THOC1 | THO complex 1 | 0.0267496 |
| OGA | O-GlcNAcase | 0.0264051 |
| WDR43 | WD repeat domain 43 | 0.0257699 |
| KLHL24 | kelch-like family member 24 | 0.0256975 |
| YEATS2 | YEATS domain containing 2 | 0.0255813 |
| KIF5B | kinesin family member 5B | 0.0251754 |
| RPS12 | ribosomal protein S12 | 0.0250627 |
| PNN | pinin, desmosome associated protein | 0.0250001 |
| CASC3 | cancer susceptibility candidate 3 | 0.0242639 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0241584 |
| GASK1B | golgi associated kinase 1B | 0.0240178 |
| CXADR | coxsackie virus and adenovirus receptor | 0.023945 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0236727 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0236041 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0234617 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0234577 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0233468 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0228844 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0226872 |
| MED13L | mediator complex subunit 13-like | 0.0226543 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0225666 |
| CEP192 | centrosomal protein 192kDa | 0.0224932 |
| RNF145 | ring finger protein 145 | 0.0224309 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0220476 |
| YBX3 | Y box binding protein 3 | 0.0218951 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0218213 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0217536 |
| OXR1 | oxidation resistance 1 | 0.0216543 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0216043 |
| NUP58 | nucleoporin 58 | 0.0212328 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0211757 |
| ATP11A | ATPase, class VI, type 11A | 0.0211514 |
| PTMS | parathymosin | 0.0210626 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0208268 |
| ARRDC3 | arrestin domain containing 3 | 0.0208193 |
| RPL23 | ribosomal protein L23 | 0.0207974 |
| RPL11 | ribosomal protein L11 | 0.0207674 |
| PGK1 | phosphoglycerate kinase 1 | 0.0205631 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0204417 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0203952 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0203504 |
| RPS4X | ribosomal protein S4, X-linked | 0.019898 |
| AXIN2 | axin 2 | 0.019877 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0192794 |
| NCKAP1 | NCK-associated protein 1 | 0.0192318 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0190456 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0189203 |
| RPL7 | ribosomal protein L7 | 0.0189076 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0188354 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0183485 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0178142 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0176251 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0175455 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0172099 |
| TFG | TRK-fused gene | 0.0171181 |
| CEP95 | centrosomal protein 95kDa | 0.0169696 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0169479 |
| CDK19 | cyclin-dependent kinase 19 | 0.0168398 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0166772 |
| RPS3 | ribosomal protein S3 | 0.0164668 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0164647 |
| RPL3 | ribosomal protein L3 | 0.0163891 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0163531 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0162804 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0162698 |
| HLTF | helicase-like transcription factor | 0.0162155 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0162032 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0161708 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0160854 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0159031 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0158535 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.305137 |
| NLGN1 | neuroligin 1 | -0.20576 |
| HMGA2 | high mobility group AT-hook 2 | -0.162264 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.124052 |
| PCDH7 | protocadherin 7 | -0.101578 |
| EHBP1 | EH domain binding protein 1 | -0.0941881 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0821889 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0740528 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0719928 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0708003 |
| ZNF804A | zinc finger protein 804A | -0.0704219 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0686324 |
| INTS6 | integrator complex subunit 6 | -0.0598297 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0598094 |
| NHSL1 | NHS-like 1 | -0.0587435 |
| MMP12 | matrix metallopeptidase 12 | -0.0553605 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0547901 |
| JMJD1C | jumonji domain containing 1C | -0.0546639 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0543706 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0536706 |
| YAP1 | Yes-associated protein 1 | -0.0533521 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0529925 |
| RASAL2 | RAS protein activator like 2 | -0.05269 |
| ACTG1 | actin gamma 1 | -0.051121 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0499501 |
| ADIPOR2 | adiponectin receptor 2 | -0.0494089 |
| DPYD | dihydropyrimidine dehydrogenase | -0.04604 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.044698 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.044387 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0439193 |
| EGR1 | early growth response 1 | -0.0438535 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0434013 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0430601 |
| ASPH | aspartate beta-hydroxylase | -0.0429106 |
| CUX1 | cut-like homeobox 1 | -0.0422879 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0413413 |
| NABP1 | nucleic acid binding protein 1 | -0.04096 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0399977 |
| DST | dystonin | -0.0396289 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0388827 |
| PDGFC | platelet derived growth factor C | -0.0369431 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0363512 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0347749 |
| R3HDM2 | R3H domain containing 2 | -0.0342569 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0333031 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0332061 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.0330494 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0324296 |
| BCHE | butyrylcholinesterase | -0.0321293 |
| PCDH9 | protocadherin 9 | -0.0319356 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.031455 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0311199 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0309879 |
| LRRC23 | leucine rich repeat containing 23 | -0.0292181 |
| AHNAK | AHNAK nucleoprotein | -0.0289692 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0288361 |
| CMIP | c-Maf inducing protein | -0.0285734 |
| EXOC4 | exocyst complex component 4 | -0.0282098 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0280802 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.027922 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0277103 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.027578 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.027562 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.027252 |
| HDAC9 | histone deacetylase 9 | -0.0269246 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0265613 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0265092 |
| CEP112 | centrosomal protein 112kDa | -0.0265031 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0256143 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0254738 |
| RAB10 | RAB10, member RAS oncogene family | -0.025114 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0250918 |
| NAV3 | neuron navigator 3 | -0.0249264 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0246314 |
| MTAP | methylthioadenosine phosphorylase | -0.0245862 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0244638 |
| USP34 | ubiquitin specific peptidase 34 | -0.0243494 |
| ANKRD17 | ankyrin repeat domain 17 | -0.024114 |
| MYPN | myopalladin | -0.0238999 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0238086 |
| DTNA | dystrobrevin, alpha | -0.0237545 |
| ETV6 | ets variant 6 | -0.0235849 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0235121 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.023466 |
| COMMD10 | COMM domain containing 10 | -0.0233105 |
| BPTF | bromodomain PHD finger transcription factor | -0.0232599 |
| RSU1 | Ras suppressor protein 1 | -0.0231882 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0230903 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0229743 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0227356 |
| SETX | senataxin | -0.0226097 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | -0.0222514 |
| GPHN | gephyrin | -0.021904 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0218199 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0216743 |
| CANX | calnexin | -0.0215986 |
| EGFR | epidermal growth factor receptor | -0.0211705 |
| NEBL | nebulette | -0.0210545 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0208197 |
| EDARADD | EDAR-associated death domain | -0.0206961 |
