| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemetrexed_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.121363 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0894011 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0669837 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0643856 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0632866 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0590606 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0547538 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0533901 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0502965 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0485566 |
| PGK1 | phosphoglycerate kinase 1 | 0.0442611 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0413108 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0409896 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.040973 |
| RNF149 | ring finger protein 149 | 0.0396976 |
| IFNGR1 | interferon gamma receptor 1 | 0.0384223 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0372679 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0358331 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0349732 |
| RAD51B | RAD51 paralog B | 0.0348833 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0332025 |
| XPO1 | exportin 1 | 0.033159 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0328841 |
| FNIP1 | folliculin interacting protein 1 | 0.030719 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0303471 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0300858 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0298031 |
| FAT1 | FAT atypical cadherin 1 | 0.0296182 |
| HYOU1 | hypoxia up-regulated 1 | 0.0294703 |
| DIAPH3 | diaphanous-related formin 3 | 0.0294068 |
| YEATS2 | YEATS domain containing 2 | 0.0290824 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0285361 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0282846 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0279961 |
| HELZ | helicase with zinc finger | 0.0279214 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0278721 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0272193 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.026989 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0269181 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.026681 |
| TXNIP | thioredoxin interacting protein | 0.0265674 |
| MLPH | melanophilin | 0.0263785 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0263619 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0263362 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0263123 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0261996 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0261972 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0260706 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0260421 |
| USP34 | ubiquitin specific peptidase 34 | 0.0257758 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0257173 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0255775 |
| SBF2 | SET binding factor 2 | 0.0255223 |
| ZNF652 | zinc finger protein 652 | 0.0254977 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0252619 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0252374 |
| UBC | ubiquitin C | 0.0250931 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0249178 |
| RUNX1 | runt-related transcription factor 1 | 0.024746 |
| APOL1 | apolipoprotein L, 1 | 0.0247425 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0245727 |
| OGA | O-GlcNAcase | 0.0245096 |
| SCFD1 | sec1 family domain containing 1 | 0.0244606 |
| RREB1 | ras responsive element binding protein 1 | 0.0240004 |
| ADAR | adenosine deaminase, RNA-specific | 0.0238304 |
| ENO1 | enolase 1, (alpha) | 0.0234895 |
| DENND4C | DENN/MADD domain containing 4C | 0.0234209 |
| CMIP | c-Maf inducing protein | 0.0231772 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0230854 |
| AHI1 | Abelson helper integration site 1 | 0.0227866 |
| CLTC | clathrin, heavy chain (Hc) | 0.0227205 |
| ASPH | aspartate beta-hydroxylase | 0.022591 |
| TRERF1 | transcriptional regulating factor 1 | 0.0224538 |
| DSPP | dentin sialophosphoprotein | 0.0224374 |
| PRELID2 | PRELI domain containing 2 | 0.0223489 |
| CLMN | calmin (calponin-like, transmembrane) | 0.0222174 |
| ARRDC3 | arrestin domain containing 3 | 0.0221286 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.0220564 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0217918 |
| AHNAK | AHNAK nucleoprotein | 0.0215225 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.021304 |
| GOLGA4 | golgin A4 | 0.0211209 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0210697 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0210363 |
| RBM33 | RNA binding motif protein 33 | 0.0209861 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0206273 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0203773 |
| RYK | receptor-like tyrosine kinase | 0.0202431 |
| USP49 | ubiquitin specific peptidase 49 | 0.0201932 |
| GSDMB | gasdermin B | 0.0197381 |
| USPL1 | ubiquitin specific peptidase like 1 | 0.0197248 |
| AAK1 | AP2 associated kinase 1 | 0.0197087 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0197031 |
| KDM3B | lysine (K)-specific demethylase 3B | 0.0196706 |
| HBS1L | HBS1-like translational GTPase | 0.0195665 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0193695 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | 0.0191703 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0188946 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0187723 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0186661 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.152144 |
| EGR1 | early growth response 1 | -0.122193 |
| ANXA2 | annexin A2 | -0.118409 |
| B2M | beta-2-microglobulin | -0.115204 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0948829 |
| EZR | ezrin | -0.0883764 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0792745 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0738178 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0706287 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0673876 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0667218 |
| MYO1E | myosin IE | -0.0663795 |
| VCL | vinculin | -0.0652081 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0644438 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0624503 |
| SQSTM1 | sequestosome 1 | -0.0606038 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0591212 |
| SP100 | SP100 nuclear antigen | -0.0583938 |
| PTMA | prothymosin, alpha | -0.0564213 |
| PLSCR1 | phospholipid scramblase 1 | -0.0544573 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0543352 |
| JUN | jun proto-oncogene | -0.0533234 |
| MX1 | MX dynamin-like GTPase 1 | -0.0523093 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0521249 |
| MX2 | MX dynamin-like GTPase 2 | -0.0510255 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0487203 |
| RIGI | RNA sensor RIG-I | -0.0462555 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0459748 |
| AREG | amphiregulin | -0.045523 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0443611 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0443191 |
| HLA-B | major histocompatibility complex, class I, B | -0.0427562 |
| RPS6 | ribosomal protein S6 | -0.0425772 |
| TJP1 | tight junction protein 1 | -0.0420929 |
| ERBIN | erbb2 interacting protein | -0.0419368 |
| PERP | PERP, TP53 apoptosis effector | -0.0411794 |
| PMP22 | peripheral myelin protein 22 | -0.0386328 |
| EPHB2 | EPH receptor B2 | -0.0381451 |
| INTS6 | integrator complex subunit 6 | -0.0374373 |
| CCNL1 | cyclin L1 | -0.0373659 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0367722 |
| ITGA6 | integrin, alpha 6 | -0.0357868 |
| ACTG1 | actin gamma 1 | -0.035131 |
| EFNB2 | ephrin-B2 | -0.0348335 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0341849 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0336637 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0323897 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0323 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0319165 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.031021 |
| KIAA1217 | KIAA1217 | -0.0307961 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0307844 |
| RPLP1 | ribosomal protein, large, P1 | -0.0303039 |
| TMSB10 | thymosin beta 10 | -0.029525 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0293 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0292179 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | -0.0290365 |
| KLF6 | Kruppel-like factor 6 | -0.0289671 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0288905 |
| TNS4 | tensin 4 | -0.0288356 |
| VMP1 | vacuole membrane protein 1 | -0.0284098 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0283917 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0282038 |
| RPL34 | ribosomal protein L34 | -0.0277046 |
| RPS27 | ribosomal protein S27 | -0.0274941 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.027374 |
| POTEF | POTE ankyrin domain family, member F | -0.0273355 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0273248 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0272602 |
| FOXP1 | forkhead box P1 | -0.027184 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0271042 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0270166 |
| TOX3 | TOX high mobility group box family member 3 | -0.0267852 |
| UBAP2 | ubiquitin associated protein 2 | -0.0265784 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0265639 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0265528 |
| LCN2 | lipocalin 2 | -0.026474 |
| RPS19 | ribosomal protein S19 | -0.0264048 |
| ETV6 | ets variant 6 | -0.0263862 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0262203 |
| RPL12 | ribosomal protein L12 | -0.0261993 |
| MT2A | metallothionein 2A | -0.0258855 |
| BPTF | bromodomain PHD finger transcription factor | -0.0256636 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0256313 |
| FTL | ferritin, light polypeptide | -0.0254609 |
| RPL26 | ribosomal protein L26 | -0.0254187 |
| CLDN4 | claudin 4 | -0.025352 |
| RPL35A | ribosomal protein L35a | -0.0253255 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0252059 |
| XAF1 | XIAP associated factor 1 | -0.0247608 |
| MCU | mitochondrial calcium uniporter | -0.0244189 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | -0.0242315 |
| SPATA13 | spermatogenesis associated 13 | -0.0240082 |
| ADIPOR2 | adiponectin receptor 2 | -0.0239919 |
| RPS8 | ribosomal protein S8 | -0.023977 |
| RPS3 | ribosomal protein S3 | -0.0238123 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0235911 |
| HLA-A | major histocompatibility complex, class I, A | -0.0232797 |
| NCOA7 | nuclear receptor coactivator 7 | -0.022879 |
| TC2N | tandem C2 domains, nuclear | -0.0228522 |
