Pemetrexed_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pemetrexed perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pemetrexed_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.306435
COL6A3 collagen, type VI, alpha 3 0.183961
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.11608
MYH9 myosin, heavy chain 9, non-muscle 0.108253
TRIO trio Rho guanine nucleotide exchange factor 0.0747599
ATP13A3 ATPase type 13A3 0.0686061
SMAD3 SMAD family member 3 0.0644994
LOXL2 lysyl oxidase-like 2 0.0573125
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0546231
ELL2 elongation factor, RNA polymerase II, 2 0.0544551
DPYSL3 dihydropyrimidinase-like 3 0.0446573
SPTBN1 spectrin, beta, non-erythrocytic 1 0.041125
PLEC plectin 0.0409877
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0402791
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0365958
ARRDC3 arrestin domain containing 3 0.0361116
MTSS1 metastasis suppressor 1 0.0348291
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.032321
FLNA filamin A, alpha 0.0320895
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0317963
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0316597
SPAG9 sperm associated antigen 9 0.0303197
TNIP1 TNFAIP3 interacting protein 1 0.0297916
STC1 stanniocalcin 1 0.0290018
PRELID2 PRELI domain containing 2 0.0286925
ADAM9 ADAM metallopeptidase domain 9 0.0286473
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0279876
ARHGAP29 Rho GTPase activating protein 29 0.0267448
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0266274
KDM7A lysine (K)-specific demethylase 7A 0.0264013
BHLHE40 basic helix-loop-helix family, member e40 0.0257277
VEGFA vascular endothelial growth factor A 0.025717
ANTXR2 anthrax toxin receptor 2 0.0256514
APP amyloid beta (A4) precursor protein 0.0252642
ICAM1 intercellular adhesion molecule 1 0.0251933
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0250438
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0249854
GRB10 growth factor receptor-bound protein 10 0.0242396
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0240458
NAV2 neuron navigator 2 0.023796
ERRFI1 ERBB receptor feedback inhibitor 1 0.0237273
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0235721
SHB Src homology 2 domain containing adaptor protein B 0.0227969
MAP1B microtubule-associated protein 1B 0.0227637
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.022148
AMPD3 adenosine monophosphate deaminase 3 0.0213715
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0208339
ADAM12 ADAM metallopeptidase domain 12 0.0207423
SEPTIN9 septin 9 0.0205917
ECT2 epithelial cell transforming 2 0.0205079
TM4SF1 transmembrane 4 L six family member 1 0.0204568
KMT2E lysine (K)-specific methyltransferase 2E 0.0204339
FLNB filamin B, beta 0.0203378
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0195458
ECE1 endothelin converting enzyme 1 0.0195001
ADAM17 ADAM metallopeptidase domain 17 0.0194606
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0194364
SMC4 structural maintenance of chromosomes 4 0.0191785
CENPF centromere protein F, 350/400kDa 0.019113
HAS2 hyaluronan synthase 2 0.0190257
CKAP5 cytoskeleton associated protein 5 0.0187874
ANLN anillin, actin binding protein 0.0185788
ACTN4 actinin, alpha 4 0.0185541
YEATS2 YEATS domain containing 2 0.0183319
RIPK2 receptor-interacting serine-threonine kinase 2 0.0182113
SOCS5 suppressor of cytokine signaling 5 0.0182035
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.018125
RARB retinoic acid receptor, beta 0.0180589
ANO6 anoctamin 6 0.0177054
ESYT2 extended synaptotagmin-like protein 2 0.0176567
RNF220 ring finger protein 220 0.017613
FAT1 FAT atypical cadherin 1 0.0174099
PDE10A phosphodiesterase 10A 0.0174065
UBA6 ubiquitin-like modifier activating enzyme 6 0.0173944
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0173677
MKI67 marker of proliferation Ki-67 0.0173452
AFAP1 actin filament associated protein 1 0.016956
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0168431
CD44 CD44 molecule (Indian blood group) 0.0166178
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0164255
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0162602
KIAA1217 KIAA1217 0.0161624
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0160026
AXL AXL receptor tyrosine kinase 0.0159838
DLG1 discs, large homolog 1 (Drosophila) 0.0156023
ABLIM3 actin binding LIM protein family, member 3 0.0154908
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0153415
DST dystonin 0.0151755
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.015147
SBF2 SET binding factor 2 0.0151242
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0151044
COL6A1 collagen, type VI, alpha 1 0.0149654
INHBA inhibin, beta A 0.0148689
KLF6 Kruppel-like factor 6 0.0148528
PRKCSH protein kinase C substrate 80K-H 0.0146943
XPO1 exportin 1 0.0146204
JMJD1C jumonji domain containing 1C 0.0144866
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0144567
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0144145
TIMP3 TIMP metallopeptidase inhibitor 3 0.0142826

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.198663
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.139742
MT2A metallothionein 2A -0.130442
IGFBP3 insulin-like growth factor binding protein 3 -0.129405
COL1A1 collagen, type I, alpha 1 -0.123438
TMSB10 thymosin beta 10 -0.116915
VIM vimentin -0.112075
CDH13 cadherin 13 -0.110948
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0991229
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0986564
RPS8 ribosomal protein S8 -0.091326
FTL ferritin, light polypeptide -0.0787352
NDRG1 N-myc downstream regulated 1 -0.0709456
RPL35A ribosomal protein L35a -0.064831
IER3 immediate early response 3 -0.0617997
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0570642
RPS6 ribosomal protein S6 -0.0562705
ACTG1 actin gamma 1 -0.0558399
RPS19 ribosomal protein S19 -0.0460665
PTMA prothymosin, alpha -0.0456312
RPL11 ribosomal protein L11 -0.0455462
EIF1 eukaryotic translation initiation factor 1 -0.0450875
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0435557
ZSWIM6 zinc finger, SWIM-type containing 6 -0.042968
RPL5 ribosomal protein L5 -0.0422525
RPL23 ribosomal protein L23 -0.041104
RAB2A RAB2A, member RAS oncogene family -0.0410392
RPS3 ribosomal protein S3 -0.040961
RPL28 ribosomal protein L28 -0.0408599
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0406457
TGFBI transforming growth factor, beta-induced, 68kDa -0.0401551
RPL12 ribosomal protein L12 -0.0397313
TPT1 tumor protein, translationally-controlled 1 -0.0380416
RPL37A ribosomal protein L37a -0.0374184
CALR calreticulin -0.0373392
RPL26 ribosomal protein L26 -0.0373143
RPL36 ribosomal protein L36 -0.0368863
RPL30 ribosomal protein L30 -0.0368114
RPLP1 ribosomal protein, large, P1 -0.0367999
COL1A2 collagen, type I, alpha 2 -0.0365325
RACK1 receptor for activated C kinase 1 -0.0363564
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0363455
S100A9 S100 calcium binding protein A9 -0.0359435
MTDH metadherin -0.0356464
TRPS1 trichorhinophalangeal syndrome I -0.0353057
LOX lysyl oxidase -0.0352479
RPLP2 ribosomal protein, large, P2 -0.0345454
RPS12 ribosomal protein S12 -0.0344127
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0341843
FBN1 fibrillin 1 -0.0337863
ANKRD11 ankyrin repeat domain 11 -0.0332871
HLA-B major histocompatibility complex, class I, B -0.0332288
RPL34 ribosomal protein L34 -0.0330632
PSD3 pleckstrin and Sec7 domain containing 3 -0.0324001
SQSTM1 sequestosome 1 -0.0322777
NALF1 NALCN channel auxiliary factor 1 -0.0316979
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0310816
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0307386
TTC3 tetratricopeptide repeat domain 3 -0.0301508
RPL7 ribosomal protein L7 -0.0297709
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0297157
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0296235
DPYD dihydropyrimidine dehydrogenase -0.0292085
RPS20 ribosomal protein S20 -0.0289242
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0285632
RPL8 ribosomal protein L8 -0.0284924
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0282396
RPL31 ribosomal protein L31 -0.0280638
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0278414
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0277621
IARS1 isoleucyl-tRNA synthetase 1 -0.0277091
NEK10 NIMA-related kinase 10 -0.0275314
RPS16 ribosomal protein S16 -0.0275015
SPDYA speedy/RINGO cell cycle regulator family member A -0.0270917
RPS5 ribosomal protein S5 -0.0270346
ENO1 enolase 1, (alpha) -0.0270146
RPL19 ribosomal protein L19 -0.0266935
RPL37 ribosomal protein L37 -0.0262208
B2M beta-2-microglobulin -0.0259839
FTH1 ferritin, heavy polypeptide 1 -0.0254403
RPS13 ribosomal protein S13 -0.0253848
RPLP0 ribosomal protein, large, P0 -0.0252048
RPS24 ribosomal protein S24 -0.0251825
ZFAND3 zinc finger, AN1-type domain 3 -0.0248181
ZBTB20 zinc finger and BTB domain containing 20 -0.0243848
EGR1 early growth response 1 -0.0242913
NAP1L1 nucleosome assembly protein 1-like 1 -0.0241492
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0241175
RPL9 ribosomal protein L9 -0.0239681
COL5A1 collagen, type V, alpha 1 -0.0232751
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0231793
RND3 Rho family GTPase 3 -0.0230116
DGKI diacylglycerol kinase, iota -0.0229134
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0227013
RPS14 ribosomal protein S14 -0.0226307
GOLGB1 golgin B1 -0.0224327
MT1X metallothionein 1X -0.0223062
HM13 histocompatibility (minor) 13 -0.0222801
RPL18 ribosomal protein L18 -0.0221456
RPS25 ribosomal protein S25 -0.0220162