| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemetrexed_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.176721 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0955741 |
| TF | transferrin | 0.0944208 |
| APOB | apolipoprotein B | 0.0897895 |
| C3 | complement component 3 | 0.0825263 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0798982 |
| FN1 | fibronectin 1 | 0.0632021 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0623071 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0598276 |
| DSPP | dentin sialophosphoprotein | 0.0581781 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0562515 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0548532 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0531608 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0513428 |
| TRIM26 | tripartite motif containing 26 | 0.0463316 |
| AFDN | afadin, adherens junction formation factor | 0.0424625 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0407831 |
| LYZ | lysozyme | 0.0378927 |
| PEG3 | paternally expressed 3 | 0.0348603 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0337789 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0300096 |
| VEGFA | vascular endothelial growth factor A | 0.0297659 |
| A2M | alpha-2-macroglobulin | 0.029461 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0257237 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0251486 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0241234 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0231304 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0230529 |
| DTNA | dystrobrevin, alpha | 0.0224975 |
| PLEC | plectin | 0.0223983 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0219731 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0213988 |
| AHSG | alpha-2-HS-glycoprotein | 0.0211713 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0210052 |
| RPL4 | ribosomal protein L4 | 0.0208222 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0195138 |
| FLNB | filamin B, beta | 0.0194626 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0194158 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0194047 |
| PCBP2 | poly(rC) binding protein 2 | 0.0193055 |
| ARRDC3 | arrestin domain containing 3 | 0.0192411 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0191281 |
| CFB | complement factor B | 0.0188512 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0186386 |
| SEPTIN9 | septin 9 | 0.0183485 |
| HLF | hepatic leukemia factor | 0.0181322 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0178343 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0176941 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0176701 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0175648 |
| CLU | clusterin | 0.0174932 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0172843 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0171897 |
| LDHA | lactate dehydrogenase A | 0.0167924 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.016699 |
| TNS1 | tensin 1 | 0.0166711 |
| TOP1 | topoisomerase (DNA) I | 0.0165364 |
| XPO1 | exportin 1 | 0.0164151 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0161394 |
| PDE8A | phosphodiesterase 8A | 0.0160295 |
| RPL3 | ribosomal protein L3 | 0.016029 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0159568 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0157222 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0156903 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0156846 |
| EFNA1 | ephrin-A1 | 0.0155963 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.015125 |
| HNRNPF | heterogeneous nuclear ribonucleoprotein F | 0.0150425 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0150214 |
| KRT18 | keratin 18, type I | 0.0149795 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0148294 |
| ATP13A3 | ATPase type 13A3 | 0.0147334 |
| SELENOP | selenoprotein P | 0.0145593 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0144945 |
| RPS7 | ribosomal protein S7 | 0.0144746 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0143908 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0142733 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0142283 |
| PTK2 | protein tyrosine kinase 2 | 0.0141279 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0140789 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.0138716 |
| ABI1 | abl-interactor 1 | 0.0138413 |
| ABAT | 4-aminobutyrate aminotransferase | 0.0137477 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0137357 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0137212 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0136218 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.013603 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0135168 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0134172 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0134044 |
| PTPN2 | protein tyrosine phosphatase, non-receptor type 2 | 0.013192 |
| OPTN | optineurin | 0.0131448 |
| DENND5A | DENN/MADD domain containing 5A | 0.0130743 |
| FAT1 | FAT atypical cadherin 1 | 0.012994 |
| YAP1 | Yes-associated protein 1 | 0.0129663 |
| QKI | QKI, KH domain containing, RNA binding | 0.0129095 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.0128496 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.012828 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0128171 |
| PDS5B | PDS5 cohesin associated factor B | 0.0128121 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.627073 |
| MT2A | metallothionein 2A | -0.217358 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.136058 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.131183 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.126051 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0938927 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0762181 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0666524 |
| RPLP1 | ribosomal protein, large, P1 | -0.0642419 |
| APOA2 | apolipoprotein A-II | -0.0621428 |
| RPL35A | ribosomal protein L35a | -0.0604928 |
| RPS24 | ribosomal protein S24 | -0.0582447 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0570337 |
| RPL34 | ribosomal protein L34 | -0.0553885 |
| RPS19 | ribosomal protein S19 | -0.0553716 |
| RPS6 | ribosomal protein S6 | -0.0550296 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0537842 |
| RPS8 | ribosomal protein S8 | -0.0526424 |
| GPC6 | glypican 6 | -0.0518796 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0516514 |
| RPL37A | ribosomal protein L37a | -0.0504992 |
| EHBP1 | EH domain binding protein 1 | -0.0492886 |
| RPS21 | ribosomal protein S21 | -0.0487873 |
| EGR1 | early growth response 1 | -0.047415 |
| RPL11 | ribosomal protein L11 | -0.0467183 |
| FTL | ferritin, light polypeptide | -0.0465462 |
| TMSB10 | thymosin beta 10 | -0.0464845 |
| RPLP2 | ribosomal protein, large, P2 | -0.0438591 |
| FOXP1 | forkhead box P1 | -0.0417859 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0415259 |
| RPL31 | ribosomal protein L31 | -0.0393406 |
| RPL26 | ribosomal protein L26 | -0.0383282 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.036168 |
| EXT1 | exostosin glycosyltransferase 1 | -0.035472 |
| RPS13 | ribosomal protein S13 | -0.0350374 |
| PARD3 | par-3 family cell polarity regulator | -0.0331942 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0331517 |
| ATXN1 | ataxin 1 | -0.0327003 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0325097 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0317949 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0314309 |
| RPS10 | ribosomal protein S10 | -0.0308447 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.030228 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.0298319 |
| RPS27A | ribosomal protein S27a | -0.0297426 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0286231 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0286154 |
| ACTG1 | actin gamma 1 | -0.0283641 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0278298 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0276649 |
| RPS29 | ribosomal protein S29 | -0.0274724 |
| RPL9 | ribosomal protein L9 | -0.0270333 |
| RPL30 | ribosomal protein L30 | -0.0268455 |
| RPL38 | ribosomal protein L38 | -0.0267891 |
| RPS15 | ribosomal protein S15 | -0.0267472 |
| GPC3 | glypican 3 | -0.0266832 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0266011 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0262386 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0259705 |
| RPL23 | ribosomal protein L23 | -0.0259563 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0257791 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0254423 |
| NDRG1 | N-myc downstream regulated 1 | -0.0253562 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0252772 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0252441 |
| RPLP0 | ribosomal protein, large, P0 | -0.0251394 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0249647 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0248903 |
| RPL32 | ribosomal protein L32 | -0.0247306 |
| RPL27 | ribosomal protein L27 | -0.0245443 |
| RPL5 | ribosomal protein L5 | -0.0242733 |
| ITGAV | integrin, alpha V | -0.0241212 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0236649 |
| GNAS | GNAS complex locus | -0.0236027 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0234332 |
| IER3 | immediate early response 3 | -0.023254 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0227046 |
| RPL37 | ribosomal protein L37 | -0.022596 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0225688 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0223135 |
| RPL7A | ribosomal protein L7a | -0.0221869 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0221409 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0221088 |
| S100A9 | S100 calcium binding protein A9 | -0.0219274 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -0.0219233 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0218448 |
| FAM107B | family with sequence similarity 107, member B | -0.0217642 |
| KIF21A | kinesin family member 21A | -0.0214101 |
| B2M | beta-2-microglobulin | -0.0213695 |
| BPTF | bromodomain PHD finger transcription factor | -0.0213119 |
| GOLGB1 | golgin B1 | -0.0211184 |
| PTCHD4 | patched domain containing 4 | -0.0210036 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0205009 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0204504 |
| RPL10A | ribosomal protein L10a | -0.0203328 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0201477 |
| RNF213 | ring finger protein 213 | -0.0199573 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0197296 |
| RPS14 | ribosomal protein S14 | -0.0196995 |
| SVIL | supervillin | -0.0196594 |
