Pemetrexed_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pemetrexed perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pemetrexed_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.218203
FLNB filamin B, beta 0.191525
MYH9 myosin, heavy chain 9, non-muscle 0.146381
PTMA prothymosin, alpha 0.112327
FLNA filamin A, alpha 0.097272
CLU clusterin 0.0797745
KRT17 keratin 17, type I 0.0795965
MSN moesin 0.0759176
PLEC plectin 0.0743127
PODXL podocalyxin-like 0.0701919
PGK1 phosphoglycerate kinase 1 0.0701194
APLP2 amyloid beta (A4) precursor-like protein 2 0.0698995
CANX calnexin 0.0694124
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0646396
B2M beta-2-microglobulin 0.0587474
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0580912
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0577985
BHLHE40 basic helix-loop-helix family, member e40 0.0561264
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0546979
SQLE squalene epoxidase 0.0537559
CD9 CD9 molecule 0.0526993
LDHA lactate dehydrogenase A 0.0518139
ALCAM activated leukocyte cell adhesion molecule 0.0511933
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0508023
RPS3 ribosomal protein S3 0.0495349
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0490693
ENO1 enolase 1, (alpha) 0.0487887
RAI14 retinoic acid induced 14 0.0485377
MYO10 myosin X 0.0475532
CALR calreticulin 0.0465723
NCOR2 nuclear receptor corepressor 2 0.045578
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0442831
TNIP1 TNFAIP3 interacting protein 1 0.0422854
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0420565
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0411955
TGM2 transglutaminase 2 0.0410859
KRT14 keratin 14, type I 0.0406265
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0405844
ITGA6 integrin, alpha 6 0.0404153
PRRC2C proline-rich coiled-coil 2C 0.0394495
MACF1 microtubule-actin crosslinking factor 1 0.0390447
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0378318
RPL11 ribosomal protein L11 0.0357728
RPL7 ribosomal protein L7 0.0357149
CEP250 centrosomal protein 250kDa 0.0354241
HLA-E major histocompatibility complex, class I, E 0.0353217
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0352213
PKM pyruvate kinase, muscle 0.0349503
TMSB10 thymosin beta 10 0.0348605
MCL1 myeloid cell leukemia 1 0.0347132
ARRDC3 arrestin domain containing 3 0.0346198
TPM3 tropomyosin 3 0.0345128
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0339727
EZR ezrin 0.0338148
ANO1 anoctamin 1, calcium activated chloride channel 0.0335616
TMSB4X thymosin beta 4, X-linked 0.0331885
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0329581
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0328826
HDGF hepatoma-derived growth factor 0.0327746
TTC3 tetratricopeptide repeat domain 3 0.0326711
PCBP2 poly(rC) binding protein 2 0.0324353
DIAPH1 diaphanous-related formin 1 0.0322967
EMP1 epithelial membrane protein 1 0.0320521
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0318429
CALB1 calbindin 1, 28kDa 0.0317163
GOLGA4 golgin A4 0.0316154
SLK STE20-like kinase 0.0311678
SRRM2 serine/arginine repetitive matrix 2 0.0311216
KRT6A keratin 6A, type II 0.0310909
KISS1 KiSS-1 metastasis-suppressor 0.0309378
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0308953
PSD3 pleckstrin and Sec7 domain containing 3 0.0305316
COL17A1 collagen, type XVII, alpha 1 0.0300158
CAPN2 calpain 2, (m/II) large subunit 0.029818
ATF4 activating transcription factor 4 0.029724
ZEB1 zinc finger E-box binding homeobox 1 0.0296923
EFHD2 EF-hand domain family, member D2 0.0295986
RASAL2 RAS protein activator like 2 0.0294978
IGFBP6 insulin-like growth factor binding protein 6 0.0294413
LAMC2 laminin, gamma 2 0.0293508
EEF2 eukaryotic translation elongation factor 2 0.0286331
GRB10 growth factor receptor-bound protein 10 0.028205
RPS12 ribosomal protein S12 0.0280897
SET SET nuclear proto-oncogene 0.0280289
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0279718
EHBP1L1 EH domain binding protein 1-like 1 0.0276101
VEGFA vascular endothelial growth factor A 0.0274501
APP amyloid beta (A4) precursor protein 0.027312
RPS4X ribosomal protein S4, X-linked 0.0271195
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.026946
ZMIZ1 zinc finger, MIZ-type containing 1 0.0269132
PRSS23 protease, serine, 23 0.0268333
ANXA1 annexin A1 0.0266036
RPS6 ribosomal protein S6 0.026504
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0263845
KRT18 keratin 18, type I 0.0263367
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0262033
RCOR1 REST corepressor 1 0.0261707
ITPRID2 ITPR interacting domain containing 2 0.0260198
ANLN anillin, actin binding protein 0.0259954

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.112579
OSMR oncostatin M receptor -0.0899969
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0725048
CD44 CD44 molecule (Indian blood group) -0.0680104
PRELID2 PRELI domain containing 2 -0.0643881
FOXP1 forkhead box P1 -0.0613556
PDE4D phosphodiesterase 4D, cAMP-specific -0.0565741
AOPEP aminopeptidase O (putative) -0.056425
FOXO1 forkhead box O1 -0.0527518
MBNL1 muscleblind-like splicing regulator 1 -0.052328
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0494612
MYOF myoferlin -0.048955
KIAA1217 KIAA1217 -0.0484121
CEMIP cell migration inducing protein, hyaluronan binding -0.0420574
RPS21 ribosomal protein S21 -0.0413105
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0381336
RIN2 Ras and Rab interactor 2 -0.0367444
DPYD dihydropyrimidine dehydrogenase -0.0356425
RBM39 RNA binding motif protein 39 -0.0349225
KLF5 Kruppel-like factor 5 (intestinal) -0.0349076
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0346595
NEK7 NIMA-related kinase 7 -0.0342615
ANKRD10 ankyrin repeat domain 10 -0.0326329
NT5C2 5'-nucleotidase, cytosolic II -0.030105
CNTNAP3 contactin associated protein-like 3 -0.0300397
RIGI RNA sensor RIG-I -0.0300395
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0284051
LOC112694756 uncharaterized LOC112694756 -0.0283194
SMYD3 SET and MYND domain containing 3 -0.0280506
NRIP1 nuclear receptor interacting protein 1 -0.0273059
CAV1 caveolin 1, caveolae protein, 22kDa -0.0268408
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0267886
SMAD3 SMAD family member 3 -0.026624
NIPBL Nipped-B homolog (Drosophila) -0.0265923
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0261063
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0260518
NRG1 neuregulin 1 -0.0258285
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0241591
CUL4B cullin 4B -0.0240916
ARHGAP29 Rho GTPase activating protein 29 -0.0232369
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0231974
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0231571
ZNFX1 zinc finger, NFX1-type containing 1 -0.0229612
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0225495
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0224865
ANKRD12 ankyrin repeat domain 12 -0.0223705
RPS24 ribosomal protein S24 -0.0221629
ANKRD28 ankyrin repeat domain 28 -0.0217049
SLC45A4 solute carrier family 45, member 4 -0.0216072
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -0.0215905
BMAL2 basic helix-loop-helix ARNT like 2 -0.0215704
JAG1 jagged 1 -0.0215538
PDLIM5 PDZ and LIM domain 5 -0.0215107
ARF1 ADP-ribosylation factor 1 -0.0213778
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0212968
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0208448
IGF2 insulin-like growth factor 2 -0.0206593
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0203762
NIBAN2 niban apoptosis regulator 2 -0.0202364
ZNF217 zinc finger protein 217 -0.0200606
TXNRD1 thioredoxin reductase 1 -0.020024
NRCAM neuronal cell adhesion molecule -0.0198652
LDLR low density lipoprotein receptor -0.0196918
IER3 immediate early response 3 -0.0196282
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0196142
TPT1 tumor protein, translationally-controlled 1 -0.0191041
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0190258
UBE2H ubiquitin-conjugating enzyme E2H -0.0188912
EFNA5 ephrin-A5 -0.0188298
MBD5 methyl-CpG binding domain protein 5 -0.018731
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0187087
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0186167
IFI44 interferon-induced protein 44 -0.0184974
IL6ST interleukin 6 signal transducer -0.0181495
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0181182
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -0.01811
FUS FUS RNA binding protein -0.0179435
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.017842
FOXK1 forkhead box K1 -0.0177893
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0176087
IGFBP4 insulin-like growth factor binding protein 4 -0.0174407
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0172882
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0171322
MEF2C myocyte enhancer factor 2C -0.0170794
PNISR PNN-interacting serine/arginine-rich protein -0.0170384
METTL15 methyltransferase like 15 -0.0169649
SSBP2 single-stranded DNA binding protein 2 -0.0169615
RPL34 ribosomal protein L34 -0.0168084
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0164966
PHF21A PHD finger protein 21A -0.0164397
FAM3C family with sequence similarity 3, member C -0.0163461
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0162846
PALLD palladin, cytoskeletal associated protein -0.0162762
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0162554
FAF1 Fas (TNFRSF6) associated factor 1 -0.0161925
LIFR leukemia inhibitory factor receptor alpha -0.0160348
SLC38A1 solute carrier family 38, member 1 -0.0160345
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0158532
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0158142
DOK5 docking protein 5 -0.0157697