| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pemetrexed_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.149199 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.10505 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.103532 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.099632 |
| FAM13A | family with sequence similarity 13, member A | 0.0819994 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0815464 |
| PIGR | polymeric immunoglobulin receptor | 0.0774365 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0772541 |
| TXNIP | thioredoxin interacting protein | 0.0769925 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0758151 |
| KRT18 | keratin 18, type I | 0.0744191 |
| EREG | epiregulin | 0.0693133 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0690036 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0679492 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0654423 |
| GOLGA4 | golgin A4 | 0.0633618 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0572937 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0572718 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.0562036 |
| CANX | calnexin | 0.056019 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0541642 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0510792 |
| DSPP | dentin sialophosphoprotein | 0.0499024 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0489989 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0476937 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0468996 |
| MUC17 | mucin 17, cell surface associated | 0.0458468 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0454423 |
| VEGFA | vascular endothelial growth factor A | 0.0428068 |
| TMSB4X | thymosin beta 4, X-linked | 0.042552 |
| CALR | calreticulin | 0.0420563 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0419871 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0406882 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0406266 |
| YME1L1 | YME1-like 1 ATPase | 0.0406213 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0402694 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0402097 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0389418 |
| SETD5 | SET domain containing 5 | 0.0387971 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0384787 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0382201 |
| PGK1 | phosphoglycerate kinase 1 | 0.0372827 |
| TFG | TRK-fused gene | 0.0356974 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0351583 |
| NUP58 | nucleoporin 58 | 0.034899 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0348641 |
| YTHDC1 | YTH domain containing 1 | 0.0335026 |
| UBC | ubiquitin C | 0.0334611 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0334269 |
| LDHA | lactate dehydrogenase A | 0.0334056 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0324165 |
| RREB1 | ras responsive element binding protein 1 | 0.0320959 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0320288 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0320287 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0317243 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0314634 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0314233 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0311896 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0311806 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0308599 |
| HELZ | helicase with zinc finger | 0.0303242 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0301145 |
| MLEC | malectin | 0.030091 |
| RNF145 | ring finger protein 145 | 0.0296203 |
| USP3 | ubiquitin specific peptidase 3 | 0.0293835 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0292066 |
| EHF | ets homologous factor | 0.029189 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0288564 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0285514 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0284074 |
| CCNY | cyclin Y | 0.0282292 |
| RPL3 | ribosomal protein L3 | 0.0279984 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0278457 |
| MATR3 | matrin 3 | 0.0275905 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0275313 |
| FAT1 | FAT atypical cadherin 1 | 0.0275012 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0272848 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.027223 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0271552 |
| LRRC1 | leucine rich repeat containing 1 | 0.0270908 |
| OGA | O-GlcNAcase | 0.0268789 |
| ZNF292 | zinc finger protein 292 | 0.0268684 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0266889 |
| AFDN | afadin, adherens junction formation factor | 0.0266509 |
| HDLBP | high density lipoprotein binding protein | 0.026277 |
| TPD52 | tumor protein D52 | 0.0262392 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0261011 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.0260448 |
| SERINC1 | serine incorporator 1 | 0.0260167 |
| NEK7 | NIMA-related kinase 7 | 0.0259352 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0258678 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.025792 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0255801 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0255485 |
| NCKAP1 | NCK-associated protein 1 | 0.0251571 |
| RLF | rearranged L-myc fusion | 0.0250169 |
| HYOU1 | hypoxia up-regulated 1 | 0.0245297 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0244043 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0241498 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0241384 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.147125 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.126235 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.11944 |
| NPSR1 | neuropeptide S receptor 1 | -0.111124 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.111052 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.110418 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0921172 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0877242 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0860688 |
| ONECUT3 | one cut homeobox 3 | -0.0754548 |
| RPS19 | ribosomal protein S19 | -0.0747183 |
| RPS6 | ribosomal protein S6 | -0.0719027 |
| MT2A | metallothionein 2A | -0.0660167 |
| RPL35A | ribosomal protein L35a | -0.0648848 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0628875 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0617166 |
| RPLP1 | ribosomal protein, large, P1 | -0.0617084 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0599984 |
| RPL34 | ribosomal protein L34 | -0.0595306 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0577572 |
| CADPS | Ca++-dependent secretion activator | -0.0570723 |
| RPS8 | ribosomal protein S8 | -0.0558188 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0545481 |
| MYO1E | myosin IE | -0.0537246 |
| ACTG1 | actin gamma 1 | -0.0527368 |
| RPL36 | ribosomal protein L36 | -0.0521842 |
| RPLP2 | ribosomal protein, large, P2 | -0.0520834 |
| RPL37A | ribosomal protein L37a | -0.0510881 |
| FHIT | fragile histidine triad | -0.0508877 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0503254 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0500824 |
| RPL5 | ribosomal protein L5 | -0.0496026 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0488077 |
| FOXP1 | forkhead box P1 | -0.0469261 |
| RPL26 | ribosomal protein L26 | -0.0466715 |
| RPS12 | ribosomal protein S12 | -0.0448029 |
| S100P | S100 calcium binding protein P | -0.0443895 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.044302 |
| GPHN | gephyrin | -0.0436441 |
| SMYD3 | SET and MYND domain containing 3 | -0.0436078 |
| RPL9 | ribosomal protein L9 | -0.0424308 |
| RPL31 | ribosomal protein L31 | -0.0421761 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0411195 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0399895 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0380469 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0376158 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0371443 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0360596 |
| RPS21 | ribosomal protein S21 | -0.0348855 |
| RPL23 | ribosomal protein L23 | -0.0345658 |
| PTMA | prothymosin, alpha | -0.0339201 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0335338 |
| RPS24 | ribosomal protein S24 | -0.0333785 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0331171 |
| ATXN1 | ataxin 1 | -0.0329364 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0322694 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0318333 |
| FTL | ferritin, light polypeptide | -0.0314306 |
| RPS29 | ribosomal protein S29 | -0.0309615 |
| EGFR | epidermal growth factor receptor | -0.0307759 |
| POF1B | premature ovarian failure, 1B | -0.0305041 |
| S100A6 | S100 calcium binding protein A6 | -0.029986 |
| RNF217 | ring finger protein 217 | -0.0299371 |
| DIAPH2 | diaphanous-related formin 2 | -0.0298221 |
| RPL27 | ribosomal protein L27 | -0.0293776 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0289252 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0287329 |
| HMGB1 | high mobility group box 1 | -0.028283 |
| RAD51B | RAD51 paralog B | -0.028119 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0276814 |
| MT1X | metallothionein 1X | -0.0276599 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0270799 |
| RPS27A | ribosomal protein S27a | -0.0270562 |
| CD44 | CD44 molecule (Indian blood group) | -0.0270357 |
| ITGA6 | integrin, alpha 6 | -0.0266423 |
| RPS13 | ribosomal protein S13 | -0.0263963 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0263249 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.026295 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0260311 |
| ASPH | aspartate beta-hydroxylase | -0.0258174 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0257697 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0255493 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0251695 |
| RPS25 | ribosomal protein S25 | -0.0251003 |
| RPL37 | ribosomal protein L37 | -0.0249814 |
| RPL7A | ribosomal protein L7a | -0.0249648 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0247772 |
| RPL38 | ribosomal protein L38 | -0.0244391 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0243655 |
| PRDX1 | peroxiredoxin 1 | -0.0243131 |
| RPL28 | ribosomal protein L28 | -0.0240451 |
| MUC13 | mucin 13, cell surface associated | -0.0240079 |
| RPS11 | ribosomal protein S11 | -0.0239543 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0238438 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0237341 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0236321 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0235633 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0234812 |
| PALLD | palladin, cytoskeletal associated protein | -0.0233307 |
| VCL | vinculin | -0.0229561 |
