Pemetrexed_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pemetrexed perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pemetrexed_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.149965
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0811704
MYH9 myosin, heavy chain 9, non-muscle 0.0698878
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0679727
EEF2 eukaryotic translation elongation factor 2 0.0569472
ENO2 enolase 2 (gamma, neuronal) 0.0483874
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.043582
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0435464
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0414041
CAPRIN2 caprin family member 2 0.0387604
EEF1G eukaryotic translation elongation factor 1 gamma 0.0386534
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0348881
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0341971
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0336343
RPL3 ribosomal protein L3 0.0330547
FLNB filamin B, beta 0.0329453
ERRFI1 ERBB receptor feedback inhibitor 1 0.032885
FMNL2 formin-like 2 0.0327356
ARRDC3 arrestin domain containing 3 0.0315619
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0304868
PTPRF protein tyrosine phosphatase, receptor type, F 0.030287
PLEC plectin 0.0302297
MSN moesin 0.0300607
CANX calnexin 0.0292333
PLK2 polo-like kinase 2 0.0290688
MCL1 myeloid cell leukemia 1 0.0289614
HDGF hepatoma-derived growth factor 0.0279398
RCOR1 REST corepressor 1 0.0277209
CMIP c-Maf inducing protein 0.0276236
SEPTIN9 septin 9 0.02753
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0271264
RPL13A ribosomal protein L13a 0.0265033
FLNA filamin A, alpha 0.0264359
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0260394
VEGFA vascular endothelial growth factor A 0.0257019
DDIT4 DNA-damage-inducible transcript 4 0.0251278
RPS4X ribosomal protein S4, X-linked 0.0250753
RASAL2 RAS protein activator like 2 0.0248375
TXNIP thioredoxin interacting protein 0.0241178
BEGAIN brain-enriched guanylate kinase-associated 0.0239057
RPS23 ribosomal protein S23 0.0236409
HSPA8 heat shock 70kDa protein 8 0.0233445
RPS12 ribosomal protein S12 0.0232632
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0231178
KRT18 keratin 18, type I 0.0229713
EFNA5 ephrin-A5 0.0229652
SMAD3 SMAD family member 3 0.0229374
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0227834
HYOU1 hypoxia up-regulated 1 0.0224344
RPS3 ribosomal protein S3 0.0222724
GRIPAP1 GRIP1 associated protein 1 0.0222628
RPL7 ribosomal protein L7 0.0222381
SDK1 sidekick cell adhesion molecule 1 0.0220589
CEP250 centrosomal protein 250kDa 0.0219467
RPS17 ribosomal protein S17 0.0218844
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0216714
RPS18 ribosomal protein S18 0.0216182
TPM3 tropomyosin 3 0.0212677
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0212603
ADARB1 adenosine deaminase, RNA-specific, B1 0.020866
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0208075
GYS1 glycogen synthase 1 (muscle) 0.0207763
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0204931
PCBP2 poly(rC) binding protein 2 0.0204253
CALR calreticulin 0.0199665
PTMA prothymosin, alpha 0.0199428
CLIP2 CAP-GLY domain containing linker protein 2 0.0198855
MBNL2 muscleblind-like splicing regulator 2 0.0196048
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0192278
HPCAL1 hippocalcin-like 1 0.019002
BHLHE40 basic helix-loop-helix family, member e40 0.0188288
MAT2A methionine adenosyltransferase II, alpha 0.018686
CDK19 cyclin-dependent kinase 19 0.0186313
MYO18A myosin XVIIIA 0.0185908
ADAR adenosine deaminase, RNA-specific 0.0184181
NCOR2 nuclear receptor corepressor 2 0.0183819
RAD23B RAD23 homolog B (S. cerevisiae) 0.0182463
TGM2 transglutaminase 2 0.0180476
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.0180365
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0177949
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0175862
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0173445
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0173179
PGK1 phosphoglycerate kinase 1 0.0172651
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0172258
EIF5 eukaryotic translation initiation factor 5 0.0172146
TIMP2 TIMP metallopeptidase inhibitor 2 0.0171178
FNBP4 formin binding protein 4 0.0170524
FAM13A family with sequence similarity 13, member A 0.0169649
ZDHHC14 zinc finger, DHHC-type containing 14 0.016721
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0167169
ZMIZ1 zinc finger, MIZ-type containing 1 0.0166329
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0166273
NFE2L1 nuclear factor, erythroid 2-like 1 0.0165911
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0165801
RPL4 ribosomal protein L4 0.0164917
PDIA4 protein disulfide isomerase family A, member 4 0.0163695
SNX5 sorting nexin 5 0.0163426
DIAPH1 diaphanous-related formin 1 0.0162788
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0160849

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.2586
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.176214
TM4SF1 transmembrane 4 L six family member 1 -0.148242
MT2A metallothionein 2A -0.147689
ACTG1 actin gamma 1 -0.106781
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0958415
TMSB10 thymosin beta 10 -0.0933791
TXNRD1 thioredoxin reductase 1 -0.0925399
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0857792
TP63 tumor protein p63 -0.0806056
CD44 CD44 molecule (Indian blood group) -0.078986
PSD3 pleckstrin and Sec7 domain containing 3 -0.0715064
SRGN serglycin -0.0650766
LOC112694756 uncharaterized LOC112694756 -0.0649307
ARHGAP5 Rho GTPase activating protein 5 -0.0615363
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.058756
AHNAK AHNAK nucleoprotein -0.0558337
TMSB4X thymosin beta 4, X-linked -0.0540424
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0519136
RAI1 retinoic acid induced 1 -0.0496082
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0494321
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0478272
KMT2E lysine (K)-specific methyltransferase 2E -0.0472059
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0467502
RPL35A ribosomal protein L35a -0.04621
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0453945
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0453442
RIGI RNA sensor RIG-I -0.0438389
EREG epiregulin -0.0426388
ZMYND8 zinc finger, MYND-type containing 8 -0.0426347
WARS1 tryptophanyl-tRNA synthetase 1 -0.0425731
GCLM glutamate-cysteine ligase, modifier subunit -0.0423507
TRIP12 thyroid hormone receptor interactor 12 -0.0421459
RTN4 reticulon 4 -0.0413225
MT1E metallothionein 1E -0.0412249
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0404628
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0391419
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0390344
SLC38A2 solute carrier family 38, member 2 -0.0382476
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0381581
ANXA1 annexin A1 -0.037917
TMEM41B transmembrane protein 41B -0.0376524
FBXO11 F-box protein 11 -0.037646
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.037291
WSB1 WD repeat and SOCS box containing 1 -0.0360265
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0357157
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0356434
NAMPT nicotinamide phosphoribosyltransferase -0.0356115
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0353146
JMJD1C jumonji domain containing 1C -0.0339902
AFF4 AF4/FMR2 family, member 4 -0.0334993
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0334431
TPT1 tumor protein, translationally-controlled 1 -0.0331896
KPNB1 karyopherin (importin) beta 1 -0.0329753
KLF6 Kruppel-like factor 6 -0.0327453
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.032665
RPS24 ribosomal protein S24 -0.0323306
DPYD dihydropyrimidine dehydrogenase -0.0323149
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0321002
GNAS GNAS complex locus -0.031761
SLC38A1 solute carrier family 38, member 1 -0.0314586
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0313664
ZFR zinc finger RNA binding protein -0.0313291
OSMR oncostatin M receptor -0.0311071
RPLP0 ribosomal protein, large, P0 -0.0309967
BZW1 basic leucine zipper and W2 domains 1 -0.0309456
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0308013
CADM2 cell adhesion molecule 2 -0.0305713
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0302949
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0301253
FUS FUS RNA binding protein -0.0299542
S100A10 S100 calcium binding protein A10 -0.029828
SPRY4 sprouty homolog 4 (Drosophila) -0.0298276
RBM25 RNA binding motif protein 25 -0.0295094
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0295092
CENPF centromere protein F, 350/400kDa -0.029394
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0291684
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.0291233
RPL26 ribosomal protein L26 -0.0290993
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0285747
BIRC3 baculoviral IAP repeat containing 3 -0.0283671
NT5E 5'-nucleotidase, ecto (CD73) -0.0282983
SMC4 structural maintenance of chromosomes 4 -0.0282816
ADGRG6 adhesion G protein-coupled receptor G6 -0.0282346
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0282141
DEK DEK proto-oncogene -0.0279916
EIF1 eukaryotic translation initiation factor 1 -0.0278117
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0278071
ZNF217 zinc finger protein 217 -0.0275734
TMEM123 transmembrane protein 123 -0.0271495
MT1X metallothionein 1X -0.0270607
HLA-B major histocompatibility complex, class I, B -0.0270046
NPAS2 neuronal PAS domain protein 2 -0.0269797
CFAP299 cilia and flagella associated protein 299 -0.0268026
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0267689
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.026741
SDC4 syndecan 4 -0.0265249
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0264929
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0263326
NPR2 natriuretic peptide receptor 2 -0.0260182