| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemetrexed_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAM13A | family with sequence similarity 13, member A | 0.0563385 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.054182 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0473414 |
| CES1 | carboxylesterase 1 | 0.0424967 |
| ARRDC3 | arrestin domain containing 3 | 0.0424111 |
| PLEC | plectin | 0.0417366 |
| NGLY1 | N-glycanase 1 | 0.0413428 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0376712 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0372025 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0355981 |
| SMAD3 | SMAD family member 3 | 0.0348399 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0324933 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0313284 |
| LAMB3 | laminin, beta 3 | 0.0304774 |
| HYOU1 | hypoxia up-regulated 1 | 0.0292784 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0280566 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0274408 |
| OGA | O-GlcNAcase | 0.0268182 |
| PGK1 | phosphoglycerate kinase 1 | 0.0267049 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0263335 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0256856 |
| LAMC2 | laminin, gamma 2 | 0.0256329 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0254946 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0251586 |
| CANX | calnexin | 0.0236941 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0229562 |
| YEATS2 | YEATS domain containing 2 | 0.0221965 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0215589 |
| ANO6 | anoctamin 6 | 0.0214276 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0208946 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0205712 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.0205642 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0204021 |
| RPL4 | ribosomal protein L4 | 0.0196894 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0193432 |
| NDE1 | nudE neurodevelopment protein 1 | 0.0193356 |
| TXNRD1 | thioredoxin reductase 1 | 0.0190971 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0190915 |
| MKI67 | marker of proliferation Ki-67 | 0.0187941 |
| RUNX1 | runt-related transcription factor 1 | 0.0183804 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0179013 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0178186 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.01764 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0176212 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0174153 |
| CASC3 | cancer susceptibility candidate 3 | 0.0173105 |
| HDLBP | high density lipoprotein binding protein | 0.0171035 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0170649 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0166574 |
| KLC1 | kinesin light chain 1 | 0.0163435 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0157381 |
| NCKAP1 | NCK-associated protein 1 | 0.0157186 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | 0.0154965 |
| MYO1B | myosin IB | 0.0154726 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0153272 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0150402 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | 0.0148401 |
| TPD52 | tumor protein D52 | 0.0147268 |
| MATR3 | matrin 3 | 0.0143305 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0142341 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.014199 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.0141373 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0139952 |
| ATP13A3 | ATPase type 13A3 | 0.0138101 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0137352 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.013436 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0130844 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0130668 |
| TOP1 | topoisomerase (DNA) I | 0.0130527 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0130521 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.012947 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0127859 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0127705 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0123292 |
| FNIP1 | folliculin interacting protein 1 | 0.0122831 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0122709 |
| SUCO | SUN domain containing ossification factor | 0.0121573 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0121447 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | 0.0118976 |
| TMEM165 | transmembrane protein 165 | 0.0118916 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0118643 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.011771 |
| CAB39 | calcium binding protein 39 | 0.0116662 |
| GPBP1L1 | GC-rich promoter binding protein 1-like 1 | 0.0115663 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0114765 |
| PUM2 | pumilio RNA-binding family member 2 | 0.011428 |
| RNF145 | ring finger protein 145 | 0.0113417 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0111904 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0110692 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | 0.0110442 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0110055 |
| ATG16L1 | autophagy related 16-like 1 (S. cerevisiae) | 0.0109952 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0107993 |
| NUP58 | nucleoporin 58 | 0.010799 |
| PRELID2 | PRELI domain containing 2 | 0.010775 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0107493 |
| CTTN | cortactin | 0.0107051 |
| DIDO1 | death inducer-obliterator 1 | 0.0107032 |
| YY1AP1 | YY1 associated protein 1 | 0.0104687 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0104179 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.610892 |
| TMSB10 | thymosin beta 10 | -0.153604 |
| EGFR | epidermal growth factor receptor | -0.111167 |
| ACTG1 | actin gamma 1 | -0.093703 |
| EGR1 | early growth response 1 | -0.0909157 |
| S100A10 | S100 calcium binding protein A10 | -0.0883997 |
| MT2A | metallothionein 2A | -0.0801905 |
| FTL | ferritin, light polypeptide | -0.0716741 |
| INTS6 | integrator complex subunit 6 | -0.0696551 |
| RPL35A | ribosomal protein L35a | -0.0687961 |
| PTMA | prothymosin, alpha | -0.0669238 |
| NDRG1 | N-myc downstream regulated 1 | -0.0668619 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0644103 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0642061 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0582073 |
| CST3 | cystatin C | -0.0574729 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0557331 |
| RPLP1 | ribosomal protein, large, P1 | -0.0550879 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.05352 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0508151 |
| SEC61G | Sec61 gamma subunit | -0.0493964 |
| ANXA2 | annexin A2 | -0.0465945 |
| RPS25 | ribosomal protein S25 | -0.045483 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0448057 |
| ASPH | aspartate beta-hydroxylase | -0.0445588 |
| RPS8 | ribosomal protein S8 | -0.044248 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.043421 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0432704 |
| RPS6 | ribosomal protein S6 | -0.0428842 |
| RPL31 | ribosomal protein L31 | -0.0423643 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0410704 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0393672 |
| PKM | pyruvate kinase, muscle | -0.038456 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0377859 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0376725 |
| NABP1 | nucleic acid binding protein 1 | -0.0373106 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0371126 |
| RPL34 | ribosomal protein L34 | -0.0370477 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0366777 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0359808 |
| RPS23 | ribosomal protein S23 | -0.0359653 |
| FBXO11 | F-box protein 11 | -0.0352657 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0352604 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0349516 |
| RPL37A | ribosomal protein L37a | -0.0345986 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0339341 |
| POTEF | POTE ankyrin domain family, member F | -0.0339131 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0336319 |
| MYO1E | myosin IE | -0.0336261 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0332992 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0330597 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0328478 |
| STC1 | stanniocalcin 1 | -0.032825 |
| CAV2 | caveolin 2 | -0.0322978 |
| B2M | beta-2-microglobulin | -0.0319667 |
| LDHA | lactate dehydrogenase A | -0.0316357 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0311427 |
| ENO1 | enolase 1, (alpha) | -0.0307935 |
| AREG | amphiregulin | -0.0306213 |
| WASF2 | WAS protein family, member 2 | -0.0303706 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.030188 |
| RPS29 | ribosomal protein S29 | -0.0298589 |
| IER3 | immediate early response 3 | -0.0294591 |
| RPS24 | ribosomal protein S24 | -0.029328 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0292703 |
| SCEL | sciellin | -0.0289055 |
| S100P | S100 calcium binding protein P | -0.0286936 |
| KRT7 | keratin 7, type II | -0.0284628 |
| CPE | carboxypeptidase E | -0.0284412 |
| S100A9 | S100 calcium binding protein A9 | -0.0282463 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0281402 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0279618 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.027368 |
| MCL1 | myeloid cell leukemia 1 | -0.0273612 |
| RPS27A | ribosomal protein S27a | -0.0270528 |
| RPL37 | ribosomal protein L37 | -0.0270441 |
| CUX1 | cut-like homeobox 1 | -0.0269856 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0264026 |
| RPL30 | ribosomal protein L30 | -0.0263543 |
| VMP1 | vacuole membrane protein 1 | -0.0263036 |
| BPTF | bromodomain PHD finger transcription factor | -0.0260404 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.025985 |
| CCND1 | cyclin D1 | -0.0259473 |
| VCL | vinculin | -0.0258892 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0256874 |
| MYOF | myoferlin | -0.0255255 |
| S100A6 | S100 calcium binding protein A6 | -0.0251636 |
| RPL8 | ribosomal protein L8 | -0.0251466 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0251127 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.024947 |
| HLA-B | major histocompatibility complex, class I, B | -0.024819 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0247593 |
| GNAS | GNAS complex locus | -0.0246446 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0246052 |
| S100A11 | S100 calcium binding protein A11 | -0.0244652 |
| HMGA1 | high mobility group AT-hook 1 | -0.0241235 |
| FUS | FUS RNA binding protein | -0.023938 |
| RPS13 | ribosomal protein S13 | -0.0239057 |
| RPS3 | ribosomal protein S3 | -0.0235818 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0235638 |
