| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemetrexed_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.126234 |
| FAM13A | family with sequence similarity 13, member A | 0.116844 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.113633 |
| SMAD3 | SMAD family member 3 | 0.102136 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0992662 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.098227 |
| VIM | vimentin | 0.0958464 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0958371 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0890684 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.08762 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0867025 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0847537 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.081659 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0806452 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0796973 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0790809 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0775069 |
| PCBP2 | poly(rC) binding protein 2 | 0.0590379 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0584913 |
| FLNB | filamin B, beta | 0.058053 |
| OGA | O-GlcNAcase | 0.0567051 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0566471 |
| CANX | calnexin | 0.0565095 |
| ATP13A3 | ATPase type 13A3 | 0.0519466 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0515651 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0512612 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0509464 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0505675 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0505405 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0502755 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0485517 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0485248 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0481314 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0460792 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0455169 |
| SETD5 | SET domain containing 5 | 0.0445939 |
| HELZ | helicase with zinc finger | 0.0445462 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0445436 |
| USP3 | ubiquitin specific peptidase 3 | 0.0444086 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0443215 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0440704 |
| PRELID2 | PRELI domain containing 2 | 0.0427296 |
| APP | amyloid beta (A4) precursor protein | 0.0426141 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0423546 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0422372 |
| NGLY1 | N-glycanase 1 | 0.0414009 |
| GOLGA4 | golgin A4 | 0.0402821 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0400899 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0393879 |
| CEP250 | centrosomal protein 250kDa | 0.0389293 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0388769 |
| SPAG9 | sperm associated antigen 9 | 0.0387963 |
| NAV2 | neuron navigator 2 | 0.0383032 |
| RIOK3 | RIO kinase 3 | 0.0381318 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0376459 |
| RPL4 | ribosomal protein L4 | 0.0367241 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0363567 |
| OTUD7B | OTU deubiquitinase 7B | 0.036034 |
| YEATS2 | YEATS domain containing 2 | 0.0355629 |
| ANXA1 | annexin A1 | 0.0353888 |
| PFKP | phosphofructokinase, platelet | 0.0349475 |
| RNF145 | ring finger protein 145 | 0.0346295 |
| VEGFA | vascular endothelial growth factor A | 0.0342268 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0337005 |
| FMNL2 | formin-like 2 | 0.0334241 |
| XPO1 | exportin 1 | 0.0329456 |
| SUCO | SUN domain containing ossification factor | 0.0328376 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0326829 |
| MYO1B | myosin IB | 0.031854 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0317503 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0315868 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0313476 |
| FLNA | filamin A, alpha | 0.0313028 |
| CALR | calreticulin | 0.0312856 |
| CTNNBL1 | catenin, beta like 1 | 0.0308954 |
| NBAS | neuroblastoma amplified sequence | 0.0308777 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0308082 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0307069 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0302904 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0299573 |
| HYOU1 | hypoxia up-regulated 1 | 0.0299433 |
| RUNX1 | runt-related transcription factor 1 | 0.0298787 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0297818 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0292073 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0289997 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0289422 |
| PRRC2C | proline-rich coiled-coil 2C | 0.028905 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0287823 |
| CABIN1 | calcineurin binding protein 1 | 0.0283838 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0283705 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.0282744 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.028015 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0278572 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0277849 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0275377 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0275372 |
| FAM107B | family with sequence similarity 107, member B | 0.0274204 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0273722 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0272499 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0270139 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.307804 |
| CD44 | CD44 molecule (Indian blood group) | -0.139827 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.119536 |
| GLCCI1 | glucocorticoid induced 1 | -0.110072 |
| OSMR | oncostatin M receptor | -0.0955709 |
| LOX | lysyl oxidase | -0.093981 |
| TMSB10 | thymosin beta 10 | -0.0904025 |
| MT2A | metallothionein 2A | -0.0857099 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0761871 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0706984 |
| EGR1 | early growth response 1 | -0.0682768 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0642351 |
| NRG1 | neuregulin 1 | -0.0605055 |
| HMGA2 | high mobility group AT-hook 2 | -0.0604066 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0586107 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.054025 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0529422 |
| NTN4 | netrin 4 | -0.0519431 |
| FTL | ferritin, light polypeptide | -0.0495712 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.046909 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.046326 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0461368 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0450775 |
| EFNA5 | ephrin-A5 | -0.0450653 |
| BPTF | bromodomain PHD finger transcription factor | -0.0441965 |
| NRP1 | neuropilin 1 | -0.0431515 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0417353 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0410017 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0390882 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0388873 |
| RPLP1 | ribosomal protein, large, P1 | -0.038797 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0384823 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0379697 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0379173 |
| RPL35A | ribosomal protein L35a | -0.0377841 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0365685 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0351081 |
| POTEF | POTE ankyrin domain family, member F | -0.0334207 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0334026 |
| AADAC | arylacetamide deacetylase | -0.0330387 |
| GLIS3 | GLIS family zinc finger 3 | -0.0325912 |
| SYT1 | synaptotagmin I | -0.0325278 |
| VRK2 | vaccinia related kinase 2 | -0.0319982 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0317432 |
| RPS19 | ribosomal protein S19 | -0.0311782 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0308806 |
| KYNU | kynureninase | -0.0308541 |
| TNNC1 | troponin C type 1 (slow) | -0.0306486 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.030417 |
| IER3 | immediate early response 3 | -0.0301365 |
| RPL34 | ribosomal protein L34 | -0.0295159 |
| R3HDM2 | R3H domain containing 2 | -0.0291763 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0286316 |
| ZNF804A | zinc finger protein 804A | -0.0281896 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0279926 |
| MYADM | myeloid-associated differentiation marker | -0.0279713 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0278659 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0274249 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0274017 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0272887 |
| S100A10 | S100 calcium binding protein A10 | -0.0270979 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0270058 |
| MX2 | MX dynamin-like GTPase 2 | -0.0269001 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.02672 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.026444 |
| HEG1 | heart development protein with EGF-like domains 1 | -0.026316 |
| RPL28 | ribosomal protein L28 | -0.0262776 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0259389 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0258149 |
| EHBP1 | EH domain binding protein 1 | -0.0257043 |
| VMP1 | vacuole membrane protein 1 | -0.0256951 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0252845 |
| RPL31 | ribosomal protein L31 | -0.0252698 |
| FRMD4A | FERM domain containing 4A | -0.0251987 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.025002 |
| HLA-B | major histocompatibility complex, class I, B | -0.0249304 |
| WLS | wntless Wnt ligand secretion mediator | -0.0247105 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0247052 |
| RPL32 | ribosomal protein L32 | -0.0245936 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0245906 |
| RPS21 | ribosomal protein S21 | -0.0243659 |
| RPL36 | ribosomal protein L36 | -0.0241971 |
| USP34 | ubiquitin specific peptidase 34 | -0.0241876 |
| EGFR | epidermal growth factor receptor | -0.0240411 |
| ATM | ATM serine/threonine kinase | -0.0239834 |
| IL1R1 | interleukin 1 receptor, type I | -0.0236787 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0234097 |
| FNBP1 | formin binding protein 1 | -0.0232946 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0231654 |
| SYAP1 | synapse associated protein 1 | -0.0229125 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.022745 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0226379 |
| FBN1 | fibrillin 1 | -0.0225015 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0224973 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0224084 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0221733 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0220934 |
| KSR1 | kinase suppressor of ras 1 | -0.0220681 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0220643 |
| PHF14 | PHD finger protein 14 | -0.0220338 |
