| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemetrexed_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.164477 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0830835 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0754253 |
| RPL7 | ribosomal protein L7 | 0.0706342 |
| MCL1 | myeloid cell leukemia 1 | 0.0655978 |
| RPS8 | ribosomal protein S8 | 0.0572289 |
| FLNA | filamin A, alpha | 0.0518868 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.049395 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0481412 |
| RPS12 | ribosomal protein S12 | 0.0463539 |
| RPL19 | ribosomal protein L19 | 0.0452101 |
| RPL4 | ribosomal protein L4 | 0.0434083 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0429652 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.04101 |
| MT2A | metallothionein 2A | 0.0409472 |
| WWOX | WW domain containing oxidoreductase | 0.0403572 |
| RPL23 | ribosomal protein L23 | 0.0403143 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0397663 |
| HDGF | hepatoma-derived growth factor | 0.0393914 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0373096 |
| RPS17 | ribosomal protein S17 | 0.036199 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0350048 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0342501 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0339145 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0336595 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0336107 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0335525 |
| BMP6 | bone morphogenetic protein 6 | 0.0319041 |
| CALR | calreticulin | 0.0311336 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0311208 |
| PCBP2 | poly(rC) binding protein 2 | 0.0302406 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0300396 |
| TPM3 | tropomyosin 3 | 0.0297083 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0296597 |
| PTMA | prothymosin, alpha | 0.029582 |
| RPS3 | ribosomal protein S3 | 0.029552 |
| RPL13A | ribosomal protein L13a | 0.0295395 |
| RPS19 | ribosomal protein S19 | 0.0287743 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0287309 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0286265 |
| PLEC | plectin | 0.0285971 |
| RPL3 | ribosomal protein L3 | 0.0284651 |
| RPL37 | ribosomal protein L37 | 0.0280836 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0272785 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0272087 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0269863 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0268492 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0267438 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0262556 |
| FAM107B | family with sequence similarity 107, member B | 0.0261054 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0256214 |
| RPL37A | ribosomal protein L37a | 0.0255628 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0250918 |
| MYOF | myoferlin | 0.0250596 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0249252 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0247977 |
| RPS6 | ribosomal protein S6 | 0.0244052 |
| RPL26 | ribosomal protein L26 | 0.0241202 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0238778 |
| PFKP | phosphofructokinase, platelet | 0.0238322 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0237364 |
| RPL10A | ribosomal protein L10a | 0.0234584 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0232821 |
| CASC3 | cancer susceptibility candidate 3 | 0.0229723 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0227963 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0225041 |
| RPL31 | ribosomal protein L31 | 0.0224896 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0223535 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0219982 |
| H1-2 | H1.2 linker histone, cluster member | 0.0216058 |
| PNN | pinin, desmosome associated protein | 0.0216055 |
| ATP11A | ATPase, class VI, type 11A | 0.0212885 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0211115 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0210833 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0210809 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0209727 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0208601 |
| TMSB10 | thymosin beta 10 | 0.0207315 |
| RPL12 | ribosomal protein L12 | 0.0206046 |
| RPS4X | ribosomal protein S4, X-linked | 0.0204762 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0204534 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0200489 |
| ATF4 | activating transcription factor 4 | 0.0199979 |
| HYOU1 | hypoxia up-regulated 1 | 0.0199478 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0198197 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0197919 |
| STC2 | stanniocalcin 2 | 0.0196652 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0196062 |
| KRT18 | keratin 18, type I | 0.019558 |
| RRM2 | ribonucleotide reductase M2 | 0.0193318 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0190802 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0190747 |
| SMAD3 | SMAD family member 3 | 0.0190727 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0189276 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0189199 |
| LDHB | lactate dehydrogenase B | 0.0189149 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.018615 |
| CABIN1 | calcineurin binding protein 1 | 0.018599 |
| RPS26 | ribosomal protein S26 | 0.0185187 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0184267 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.249281 |
| TXNRD1 | thioredoxin reductase 1 | -0.211246 |
| IGF2 | insulin-like growth factor 2 | -0.12726 |
| HDAC9 | histone deacetylase 9 | -0.112964 |
| PARD3 | par-3 family cell polarity regulator | -0.103146 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.101681 |
| BICC1 | BicC family RNA binding protein 1 | -0.0901681 |
| NRG1 | neuregulin 1 | -0.0794089 |
| FTL | ferritin, light polypeptide | -0.0749917 |
| KYNU | kynureninase | -0.0700253 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0613824 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0606732 |
| ERBIN | erbb2 interacting protein | -0.0596266 |
| SVIL | supervillin | -0.057223 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0556542 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0538182 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0527794 |
| RBM39 | RNA binding motif protein 39 | -0.0527241 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0525266 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0523223 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0507701 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0504525 |
| ECT2 | epithelial cell transforming 2 | -0.0484708 |
| EFNA5 | ephrin-A5 | -0.0475298 |
| RAD51B | RAD51 paralog B | -0.0468092 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0458174 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0445634 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0443507 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0435939 |
| NEGR1 | neuronal growth regulator 1 | -0.0418788 |
| TBC1D5 | TBC1 domain family, member 5 | -0.04145 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0412724 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0408321 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0408167 |
| RASAL2 | RAS protein activator like 2 | -0.0404198 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.040315 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0400173 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0393793 |
| SMAD2 | SMAD family member 2 | -0.0393518 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0391686 |
| FBXO11 | F-box protein 11 | -0.0388688 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0380387 |
| OSMR | oncostatin M receptor | -0.0379552 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0379184 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0378725 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0378711 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0378707 |
| EGFR | epidermal growth factor receptor | -0.0373567 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0371257 |
| POTEF | POTE ankyrin domain family, member F | -0.0369466 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0368353 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0366925 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0363945 |
| GLIS3 | GLIS family zinc finger 3 | -0.0363804 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0361731 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0359989 |
| AK1 | adenylate kinase 1 | -0.0358188 |
| DST | dystonin | -0.0357046 |
| UTRN | utrophin | -0.0356788 |
| SPIDR | scaffolding protein involved in DNA repair | -0.034955 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0345393 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0345118 |
| EHBP1 | EH domain binding protein 1 | -0.0343931 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0343903 |
| ZNF207 | zinc finger protein 207 | -0.0343837 |
| NTN4 | netrin 4 | -0.0339903 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0334055 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.033322 |
| INO80 | INO80 complex subunit | -0.0325045 |
| SBF2 | SET binding factor 2 | -0.0322769 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0318252 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0315087 |
| ZNF804A | zinc finger protein 804A | -0.0312525 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0309547 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0302443 |
| VCL | vinculin | -0.0299676 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0298214 |
| TNRC6B | trinucleotide repeat containing 6B | -0.029776 |
| TCF12 | transcription factor 12 | -0.0297227 |
| SIK3 | SIK family kinase 3 | -0.0296987 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0296572 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0295226 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0294599 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0294494 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0293577 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0292481 |
| USP34 | ubiquitin specific peptidase 34 | -0.0291965 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0291729 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0290758 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0290373 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0289231 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.028827 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0287509 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0286551 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0283843 |
| COG5 | component of oligomeric golgi complex 5 | -0.0283118 |
| CAVIN1 | caveolae associated protein 1 | -0.0278772 |
| DENND5B | DENN/MADD domain containing 5B | -0.0278748 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.027866 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0277503 |
