| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemetrexed_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.138808 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.136021 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.133615 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.12938 |
| DTNA | dystrobrevin, alpha | 0.104645 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.104502 |
| GPC6 | glypican 6 | 0.0916873 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0909962 |
| CANX | calnexin | 0.0907978 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0904453 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0891851 |
| RPS6 | ribosomal protein S6 | 0.0868461 |
| PCBP2 | poly(rC) binding protein 2 | 0.085447 |
| DST | dystonin | 0.0840593 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0824344 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0815654 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0808842 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0808453 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0808133 |
| LSAMP | limbic system-associated membrane protein | 0.0798071 |
| FN1 | fibronectin 1 | 0.0787666 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0787537 |
| WDR45B | WD repeat domain 45B | 0.076255 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.075007 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0744968 |
| PARD3 | par-3 family cell polarity regulator | 0.0740839 |
| FRMD4A | FERM domain containing 4A | 0.0735542 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0726571 |
| OXR1 | oxidation resistance 1 | 0.0723995 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0719995 |
| DENND4A | DENN/MADD domain containing 4A | 0.0717437 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0711777 |
| MORF4L1 | mortality factor 4 like 1 | 0.0707459 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.0695886 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0683105 |
| NPTN | neuroplastin | 0.0657886 |
| FMN1 | formin 1 | 0.0655894 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0647842 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0643602 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0637283 |
| UTRN | utrophin | 0.0624938 |
| RPL37 | ribosomal protein L37 | 0.0624606 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0614477 |
| RPS3 | ribosomal protein S3 | 0.0614271 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0595927 |
| RBM39 | RNA binding motif protein 39 | 0.0592928 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0572731 |
| NUP58 | nucleoporin 58 | 0.0569305 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0568718 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0561416 |
| ZNF292 | zinc finger protein 292 | 0.0552519 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0551339 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0533851 |
| SPAG9 | sperm associated antigen 9 | 0.052955 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0526805 |
| SYT1 | synaptotagmin I | 0.0514186 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0499693 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0499241 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.048589 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0483643 |
| LAMB3 | laminin, beta 3 | 0.0483264 |
| RUNX1 | runt-related transcription factor 1 | 0.0462639 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0454011 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0438359 |
| RAD51B | RAD51 paralog B | 0.0435821 |
| MSI2 | musashi RNA-binding protein 2 | 0.0424338 |
| PTK2 | protein tyrosine kinase 2 | 0.0414693 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0410422 |
| OGA | O-GlcNAcase | 0.0399193 |
| LDHA | lactate dehydrogenase A | 0.0393455 |
| FMNL2 | formin-like 2 | 0.0384264 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0380619 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.034205 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0330504 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0330192 |
| GOLGA4 | golgin A4 | 0.0301701 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0299573 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0293782 |
| USP34 | ubiquitin specific peptidase 34 | 0.0281341 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0274969 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0252722 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0217234 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0213263 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0192064 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0181003 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0172182 |
| RNF213 | ring finger protein 213 | 0.0161856 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0156202 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0147901 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0144387 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0143493 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0135626 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0131948 |
| RPS8 | ribosomal protein S8 | 0.0130942 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0117332 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0105292 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0101984 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.00946514 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.00913514 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.00865249 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.218519 |
| MT2A | metallothionein 2A | -0.161032 |
| FNDC3B | fibronectin type III domain containing 3B | -0.150452 |
| FTL | ferritin, light polypeptide | -0.12214 |
| GRB10 | growth factor receptor-bound protein 10 | -0.11879 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.103654 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.102962 |
| FLNB | filamin B, beta | -0.0941931 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0933799 |
| VIM | vimentin | -0.0889008 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0876164 |
| HLA-B | major histocompatibility complex, class I, B | -0.0872946 |
| LMO7 | LIM domain 7 | -0.0867349 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0855703 |
| NAV2 | neuron navigator 2 | -0.0804205 |
| PTMA | prothymosin, alpha | -0.0787864 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0777712 |
| MED13L | mediator complex subunit 13-like | -0.0761491 |
| EGFR | epidermal growth factor receptor | -0.0757943 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0744587 |
| SMAD3 | SMAD family member 3 | -0.0731233 |
| POTEF | POTE ankyrin domain family, member F | -0.0716135 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0641842 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0630444 |
| LOXL2 | lysyl oxidase-like 2 | -0.0625687 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0622825 |
| RPLP1 | ribosomal protein, large, P1 | -0.0615852 |
| FBXO11 | F-box protein 11 | -0.0613993 |
| SVIL | supervillin | -0.0611187 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0610751 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0605231 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0600089 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0597833 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0596927 |
| TMSB10 | thymosin beta 10 | -0.0583532 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0580745 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0578455 |
| ZNF638 | zinc finger protein 638 | -0.0571764 |
| EFNA5 | ephrin-A5 | -0.0566014 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0539482 |
| MUC16 | mucin 16, cell surface associated | -0.053578 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.052121 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.052113 |
| ASPH | aspartate beta-hydroxylase | -0.0518467 |
| ACTG1 | actin gamma 1 | -0.0513221 |
| NDRG1 | N-myc downstream regulated 1 | -0.0510247 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0509257 |
| RAB10 | RAB10, member RAS oncogene family | -0.0499022 |
| SBF2 | SET binding factor 2 | -0.0492116 |
| KIF13B | kinesin family member 13B | -0.0489601 |
| ATOSA | atos homolog A | -0.0486838 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0481825 |
| NF1 | neurofibromin 1 | -0.0477018 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0477004 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0475767 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0472385 |
| RPL19 | ribosomal protein L19 | -0.0465289 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0452079 |
| RPL11 | ribosomal protein L11 | -0.045063 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0434687 |
| MYO1E | myosin IE | -0.04234 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0419795 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0407094 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0400693 |
| MYOF | myoferlin | -0.0390557 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.037346 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0357141 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0348161 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0324452 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0322699 |
| SMYD3 | SET and MYND domain containing 3 | -0.0317586 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0311887 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0307624 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0299761 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0298768 |
| TXNRD1 | thioredoxin reductase 1 | -0.0288757 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.028095 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0268228 |
| RAB7A | RAB7A, member RAS oncogene family | -0.026705 |
| ERBIN | erbb2 interacting protein | -0.0259846 |
| EXOC4 | exocyst complex component 4 | -0.0259612 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0254531 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0252058 |
| BPTF | bromodomain PHD finger transcription factor | -0.0237299 |
| TCF12 | transcription factor 12 | -0.0232942 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0224921 |
| B2M | beta-2-microglobulin | -0.0217077 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0213466 |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | -0.0204111 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0198433 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0189857 |
| ANXA2 | annexin A2 | -0.0188971 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0186524 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0184992 |
| RPLP2 | ribosomal protein, large, P2 | -0.0175777 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0173155 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0168237 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0167639 |
| KYNU | kynureninase | -0.0165053 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0161745 |
