| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemetrexed_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.122431 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0681768 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0664972 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0643161 |
| KRT18 | keratin 18, type I | 0.059961 |
| VIM | vimentin | 0.0577305 |
| TPM3 | tropomyosin 3 | 0.0547514 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0513817 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0506624 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0478398 |
| PRELID2 | PRELI domain containing 2 | 0.0477093 |
| OGA | O-GlcNAcase | 0.0476725 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0470266 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0457061 |
| PTMA | prothymosin, alpha | 0.0423469 |
| FLNA | filamin A, alpha | 0.0380683 |
| PCBP2 | poly(rC) binding protein 2 | 0.0377179 |
| PGK1 | phosphoglycerate kinase 1 | 0.0372288 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0363971 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0359408 |
| RPS4X | ribosomal protein S4, X-linked | 0.0346838 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0342338 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0342136 |
| TPM2 | tropomyosin 2 (beta) | 0.0340014 |
| XPO1 | exportin 1 | 0.0339471 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0329448 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0320406 |
| CEP192 | centrosomal protein 192kDa | 0.0317304 |
| CEP250 | centrosomal protein 250kDa | 0.031237 |
| YBX1 | Y box binding protein 1 | 0.0308217 |
| PLEC | plectin | 0.0297014 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0296287 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0296041 |
| FAM168A | family with sequence similarity 168, member A | 0.0292366 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.028842 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0281137 |
| RPL37A | ribosomal protein L37a | 0.0278476 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.027435 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0273268 |
| TMEM165 | transmembrane protein 165 | 0.0268133 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0265981 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0265919 |
| BBX | bobby sox homolog (Drosophila) | 0.0260906 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0260878 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0259147 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0255526 |
| RPL3 | ribosomal protein L3 | 0.025476 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0254615 |
| HYOU1 | hypoxia up-regulated 1 | 0.025052 |
| CASC3 | cancer susceptibility candidate 3 | 0.0248081 |
| PREPL | prolyl endopeptidase-like | 0.0240808 |
| PFKP | phosphofructokinase, platelet | 0.0239238 |
| MAGEA4 | melanoma antigen family A4 | 0.0237963 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0234906 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0232115 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0231746 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0230111 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0225106 |
| SMAD3 | SMAD family member 3 | 0.0221838 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0219146 |
| CABIN1 | calcineurin binding protein 1 | 0.0219005 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0211182 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0210391 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0208709 |
| YY1AP1 | YY1 associated protein 1 | 0.0207142 |
| PPP1R21 | protein phosphatase 1, regulatory subunit 21 | 0.0206637 |
| RPL4 | ribosomal protein L4 | 0.0206523 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0204693 |
| RBM33 | RNA binding motif protein 33 | 0.0204564 |
| RPS3 | ribosomal protein S3 | 0.0196676 |
| AFDN | afadin, adherens junction formation factor | 0.0196287 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0194202 |
| ENO1 | enolase 1, (alpha) | 0.0192526 |
| PNN | pinin, desmosome associated protein | 0.0191924 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0191416 |
| PFDN2 | prefoldin subunit 2 | 0.0189103 |
| CDYL | chromodomain protein, Y-like | 0.0186333 |
| RPS18 | ribosomal protein S18 | 0.0186246 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0184836 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0184444 |
| HDGF | hepatoma-derived growth factor | 0.0182905 |
| CDK19 | cyclin-dependent kinase 19 | 0.0182096 |
| ZNF292 | zinc finger protein 292 | 0.0181375 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0180281 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0180097 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0179686 |
| UBN2 | ubinuclein 2 | 0.0177373 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0176972 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0176677 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0175304 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0175225 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.0174963 |
| SPPL3 | signal peptide peptidase like 3 | 0.0172921 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0172154 |
| MSH6 | mutS homolog 6 | 0.0168304 |
| COPA | coatomer protein complex, subunit alpha | 0.0168052 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0167711 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0167443 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0167297 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0166257 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.219431 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.160021 |
| YBX3 | Y box binding protein 3 | -0.110495 |
| OSMR | oncostatin M receptor | -0.104294 |
| EGR1 | early growth response 1 | -0.0873714 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0692224 |
| NABP1 | nucleic acid binding protein 1 | -0.0675675 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0612644 |
| ACTG1 | actin gamma 1 | -0.0606444 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0605672 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0580269 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0572294 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0553475 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0539404 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0520843 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0512391 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0507026 |
| TXNRD1 | thioredoxin reductase 1 | -0.0504559 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0500915 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0492523 |
| HMGA2 | high mobility group AT-hook 2 | -0.0488959 |
| BPTF | bromodomain PHD finger transcription factor | -0.0487063 |
| CDK17 | cyclin-dependent kinase 17 | -0.0484265 |
| POTEF | POTE ankyrin domain family, member F | -0.0477557 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0473422 |
| FBXO11 | F-box protein 11 | -0.0473285 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0464947 |
| STC1 | stanniocalcin 1 | -0.0461243 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0453056 |
| VCL | vinculin | -0.044876 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.044176 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0439439 |
| PDE10A | phosphodiesterase 10A | -0.0436166 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0433313 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0432403 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0425153 |
| NF1 | neurofibromin 1 | -0.0417476 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0410601 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0405607 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0400953 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0388526 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0385407 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0374678 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0371002 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0366299 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0351769 |
| EGFR | epidermal growth factor receptor | -0.0348687 |
| R3HDM2 | R3H domain containing 2 | -0.0346271 |
| ATF6 | activating transcription factor 6 | -0.0346242 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0344679 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0342369 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.034135 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0338838 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.033527 |
| PLSCR1 | phospholipid scramblase 1 | -0.0331865 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0326242 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0321596 |
| E2F3 | E2F transcription factor 3 | -0.0321493 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0319858 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0315987 |
| SETX | senataxin | -0.0315622 |
| CALD1 | caldesmon 1 | -0.0310912 |
| HLA-B | major histocompatibility complex, class I, B | -0.0308165 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0305618 |
| KLF6 | Kruppel-like factor 6 | -0.0304911 |
| CCND1 | cyclin D1 | -0.0300563 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0299813 |
| SPIDR | scaffolding protein involved in DNA repair | -0.029574 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.029442 |
| PHF14 | PHD finger protein 14 | -0.0291853 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0291815 |
| PHF3 | PHD finger protein 3 | -0.0287522 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0286204 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0284975 |
| CAVIN1 | caveolae associated protein 1 | -0.0284153 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0281352 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0279758 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0274218 |
| VMP1 | vacuole membrane protein 1 | -0.0272796 |
| POGZ | pogo transposable element with ZNF domain | -0.0268958 |
| EHBP1 | EH domain binding protein 1 | -0.0265367 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0262686 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0260806 |
| INTS6 | integrator complex subunit 6 | -0.0260227 |
| PMP22 | peripheral myelin protein 22 | -0.0258655 |
| ST7L | suppression of tumorigenicity 7 like | -0.0257298 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0253712 |
| ZNF644 | zinc finger protein 644 | -0.0251044 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0249626 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0248136 |
| RIGI | RNA sensor RIG-I | -0.0246825 |
| AHNAK | AHNAK nucleoprotein | -0.0246018 |
| IER3 | immediate early response 3 | -0.0245429 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0242592 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0240097 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0238325 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0237532 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0237432 |
| DENND5B | DENN/MADD domain containing 5B | -0.0233204 |
| THOC2 | THO complex 2 | -0.0232871 |
