| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemetrexed_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.284746 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.15069 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0925643 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.083431 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.082574 |
| PLEC | plectin | 0.0767046 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0756864 |
| LAMC2 | laminin, gamma 2 | 0.0703025 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0655155 |
| KRT18 | keratin 18, type I | 0.0647399 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0622994 |
| CANX | calnexin | 0.0614362 |
| TMSB4X | thymosin beta 4, X-linked | 0.0598453 |
| FLNA | filamin A, alpha | 0.0587418 |
| DSPP | dentin sialophosphoprotein | 0.0573817 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0525852 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0518705 |
| NAV2 | neuron navigator 2 | 0.0513628 |
| CALR | calreticulin | 0.0485382 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0472298 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0460588 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0443374 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0438959 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0407606 |
| AHNAK | AHNAK nucleoprotein | 0.0380612 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0379117 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0368553 |
| PGK1 | phosphoglycerate kinase 1 | 0.0365758 |
| RNF213 | ring finger protein 213 | 0.0348807 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0348628 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0346507 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0344024 |
| APP | amyloid beta (A4) precursor protein | 0.0323012 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0316684 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0301246 |
| RPL4 | ribosomal protein L4 | 0.0300751 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0299807 |
| VEGFA | vascular endothelial growth factor A | 0.0299001 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0296205 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0293436 |
| FHIT | fragile histidine triad | 0.0287129 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0285618 |
| TPM3 | tropomyosin 3 | 0.0262478 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.025221 |
| CTSB | cathepsin B | 0.0251785 |
| SMAD3 | SMAD family member 3 | 0.0250918 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0244508 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.024257 |
| RPL14 | ribosomal protein L14 | 0.0242476 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0237176 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0233277 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0232758 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0231855 |
| MSN | moesin | 0.022788 |
| HMGB2 | high mobility group box 2 | 0.0226428 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0225176 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0220877 |
| SQSTM1 | sequestosome 1 | 0.0219743 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.021903 |
| ADAR | adenosine deaminase, RNA-specific | 0.0217101 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0215757 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0214692 |
| ASPH | aspartate beta-hydroxylase | 0.0213092 |
| HDLBP | high density lipoprotein binding protein | 0.0211264 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0207052 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0205727 |
| UBC | ubiquitin C | 0.0201636 |
| SEPTIN9 | septin 9 | 0.0200129 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0200091 |
| PLAU | plasminogen activator, urokinase | 0.0199703 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0199608 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0197477 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0197372 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0196541 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0192861 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0191448 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0187764 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0187328 |
| RAI14 | retinoic acid induced 14 | 0.0186841 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0186745 |
| ENO1 | enolase 1, (alpha) | 0.0186491 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0185339 |
| RAD51B | RAD51 paralog B | 0.0185289 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0183313 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.017906 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0176901 |
| LDHA | lactate dehydrogenase A | 0.0176215 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0175889 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0175536 |
| H1-4 | H1.4 linker histone, cluster member | 0.0173798 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0171528 |
| SPAG5 | sperm associated antigen 5 | 0.0171191 |
| RPS4X | ribosomal protein S4, X-linked | 0.0170819 |
| XPO1 | exportin 1 | 0.0168259 |
| SET | SET nuclear proto-oncogene | 0.0167742 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0167678 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0167604 |
| KRT8 | keratin 8, type II | 0.016702 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0164628 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0161421 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.252871 |
| POTEF | POTE ankyrin domain family, member F | -0.208163 |
| FTL | ferritin, light polypeptide | -0.186001 |
| ACTG1 | actin gamma 1 | -0.141837 |
| TMSB10 | thymosin beta 10 | -0.0949092 |
| HMGA1 | high mobility group AT-hook 1 | -0.0816957 |
| NDRG1 | N-myc downstream regulated 1 | -0.0768564 |
| RPL35A | ribosomal protein L35a | -0.0702467 |
| S100A6 | S100 calcium binding protein A6 | -0.0688976 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0655316 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0570785 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0565729 |
| RPLP1 | ribosomal protein, large, P1 | -0.0556871 |
| MT2A | metallothionein 2A | -0.0523169 |
| FAM3C | family with sequence similarity 3, member C | -0.051914 |
| ERBIN | erbb2 interacting protein | -0.0507139 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0497063 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0474412 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0473033 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.046732 |
| RBM25 | RNA binding motif protein 25 | -0.0454233 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0449468 |
| GOLGA4 | golgin A4 | -0.0435843 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0417257 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0410278 |
| RPL34 | ribosomal protein L34 | -0.0408598 |
| RNF145 | ring finger protein 145 | -0.0404088 |
| RPL30 | ribosomal protein L30 | -0.039666 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0391009 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0389398 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0385232 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.038492 |
| RPS6 | ribosomal protein S6 | -0.0384419 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0383452 |
| RACK1 | receptor for activated C kinase 1 | -0.0376395 |
| RTN4 | reticulon 4 | -0.0365799 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0356206 |
| RPLP2 | ribosomal protein, large, P2 | -0.0350204 |
| JMJD1C | jumonji domain containing 1C | -0.0349474 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0349108 |
| RPS19 | ribosomal protein S19 | -0.0346534 |
| CD2AP | CD2-associated protein | -0.0346015 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0344906 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0341782 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0339348 |
| CLDN4 | claudin 4 | -0.0334854 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.033191 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0330903 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0324403 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0316677 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0312605 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.030641 |
| ZNF292 | zinc finger protein 292 | -0.030573 |
| RPS13 | ribosomal protein S13 | -0.0298653 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0292708 |
| CDCP1 | CUB domain containing protein 1 | -0.0290927 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0288997 |
| RPL28 | ribosomal protein L28 | -0.0288826 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0285519 |
| SETD5 | SET domain containing 5 | -0.0283008 |
| RPL9 | ribosomal protein L9 | -0.0280736 |
| ZNF654 | zinc finger protein 654 | -0.0280251 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0278644 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.027845 |
| EGR1 | early growth response 1 | -0.0278179 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0277494 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0276946 |
| ANXA2 | annexin A2 | -0.0276712 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0276348 |
| RPL37A | ribosomal protein L37a | -0.0273381 |
| NR3C2 | nuclear receptor subfamily 3, group C, member 2 | -0.0270219 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0268665 |
| RAB7A | RAB7A, member RAS oncogene family | -0.026695 |
| CSTB | cystatin B (stefin B) | -0.0263884 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0261826 |
| TMEM165 | transmembrane protein 165 | -0.0261481 |
| RASA2 | RAS p21 protein activator 2 | -0.0255828 |
| RPS25 | ribosomal protein S25 | -0.0252756 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0252681 |
| DTNA | dystrobrevin, alpha | -0.0252264 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0249501 |
| PTMA | prothymosin, alpha | -0.0248176 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0247617 |
| RPL5 | ribosomal protein L5 | -0.0245461 |
| RASAL2 | RAS protein activator like 2 | -0.0243799 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0241529 |
| GNAS | GNAS complex locus | -0.0241022 |
| RPS8 | ribosomal protein S8 | -0.0240966 |
| RPL31 | ribosomal protein L31 | -0.0239599 |
| USP15 | ubiquitin specific peptidase 15 | -0.0237793 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0233899 |
| CCNL1 | cyclin L1 | -0.0233432 |
| RPL32 | ribosomal protein L32 | -0.0232462 |
| RPS5 | ribosomal protein S5 | -0.0230803 |
| RPS12 | ribosomal protein S12 | -0.0230168 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0229453 |
| TXNIP | thioredoxin interacting protein | -0.0227573 |
| TFG | TRK-fused gene | -0.0226817 |
| S100A9 | S100 calcium binding protein A9 | -0.022605 |
| OXSR1 | oxidative stress responsive 1 | -0.0224966 |
