Pemetrexed_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pemetrexed perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pemetrexed_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.133408
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.117635
FN1 fibronectin 1 0.0904791
PDE4D phosphodiesterase 4D, cAMP-specific 0.0856358
FNDC3B fibronectin type III domain containing 3B 0.0830835
NAMPT nicotinamide phosphoribosyltransferase 0.0823671
MCL1 myeloid cell leukemia 1 0.0786949
ESYT2 extended synaptotagmin-like protein 2 0.0753362
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0729901
PGK1 phosphoglycerate kinase 1 0.0711337
SPAG9 sperm associated antigen 9 0.0670113
ASPH aspartate beta-hydroxylase 0.0629162
SOD2 superoxide dismutase 2, mitochondrial 0.0625723
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0545726
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0543635
ERRFI1 ERBB receptor feedback inhibitor 1 0.0529759
TRIO trio Rho guanine nucleotide exchange factor 0.0521466
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0511192
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0504596
FAM13A family with sequence similarity 13, member A 0.0460977
FLNA filamin A, alpha 0.0450472
NCAM1 neural cell adhesion molecule 1 0.0438039
OGA O-GlcNAcase 0.0421319
AGFG1 ArfGAP with FG repeats 1 0.0420087
DGKD diacylglycerol kinase, delta 130kDa 0.041866
NRCAM neuronal cell adhesion molecule 0.0412697
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0406198
TNIP1 TNFAIP3 interacting protein 1 0.0398957
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0397222
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.03892
EEF2 eukaryotic translation elongation factor 2 0.0380136
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0380001
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0379515
FLNB filamin B, beta 0.0375105
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.03736
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0373117
KDM6A lysine (K)-specific demethylase 6A 0.0367932
KMT2C lysine (K)-specific methyltransferase 2C 0.0365589
PSD3 pleckstrin and Sec7 domain containing 3 0.0365191
LIMCH1 LIM and calponin homology domains 1 0.0350587
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0349617
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0346335
DNER delta/notch-like EGF repeat containing 0.0345529
PCBP3 poly(rC) binding protein 3 0.0339089
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0328924
MYOF myoferlin 0.032777
USP9X ubiquitin specific peptidase 9, X-linked 0.0320031
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0317365
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0317094
ELL2 elongation factor, RNA polymerase II, 2 0.0315514
HELZ helicase with zinc finger 0.0312348
CDH13 cadherin 13 0.0311282
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0307951
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0307841
KDM3A lysine (K)-specific demethylase 3A 0.0307791
GRB10 growth factor receptor-bound protein 10 0.030161
HSPA8 heat shock 70kDa protein 8 0.0299933
GRAMD1B GRAM domain containing 1B 0.0297473
NBAS neuroblastoma amplified sequence 0.0295315
PYGL phosphorylase, glycogen, liver 0.0295007
SUCO SUN domain containing ossification factor 0.0287266
MYH9 myosin, heavy chain 9, non-muscle 0.0286305
APP amyloid beta (A4) precursor protein 0.028406
ZC3H11A zinc finger CCCH-type containing 11A 0.028346
NCOR2 nuclear receptor corepressor 2 0.0281144
ANO6 anoctamin 6 0.0274143
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0273632
CDC73 cell division cycle 73 0.0272595
XPO1 exportin 1 0.0272135
CTBP2 C-terminal binding protein 2 0.0271709
BDNF brain-derived neurotrophic factor 0.0271309
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0266811
BIRC6 baculoviral IAP repeat containing 6 0.0264018
BRWD3 bromodomain and WD repeat domain containing 3 0.0263944
RGS2 regulator of G-protein signaling 2 0.0261003
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0260922
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0260644
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0259916
BZW1 basic leucine zipper and W2 domains 1 0.0258338
ZNF292 zinc finger protein 292 0.0256173
LDHA lactate dehydrogenase A 0.0256087
KMT2E lysine (K)-specific methyltransferase 2E 0.0249298
CAMTA1 calmodulin binding transcription activator 1 0.0244558
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0243555
ARRDC3 arrestin domain containing 3 0.0241546
UBC ubiquitin C 0.0240683
TPM3 tropomyosin 3 0.0239714
ITPRID2 ITPR interacting domain containing 2 0.0238546
CXCL8 chemokine (C-X-C motif) ligand 8 0.0236223
NCKAP1 NCK-associated protein 1 0.0236144
ZFC3H1 zinc finger, C3H1-type containing 0.0235855
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0235544
YEATS2 YEATS domain containing 2 0.0235434
CHD1L chromodomain helicase DNA binding protein 1-like 0.0230843
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0229822
NGLY1 N-glycanase 1 0.0227432
BHLHE40 basic helix-loop-helix family, member e40 0.0226952
NUP58 nucleoporin 58 0.0224763
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0221813
DOCK4 dedicator of cytokinesis 4 0.0220796

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.224477
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121123
TMSB10 thymosin beta 10 -0.0981428
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0830552
FTL ferritin, light polypeptide -0.0772777
RPS6 ribosomal protein S6 -0.0725595
RPLP1 ribosomal protein, large, P1 -0.0664914
VIM vimentin -0.061095
PDLIM5 PDZ and LIM domain 5 -0.0591054
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0566233
RPL37A ribosomal protein L37a -0.0543117
GDA guanine deaminase -0.0533388
RPL26 ribosomal protein L26 -0.0530216
RPL31 ribosomal protein L31 -0.0520735
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0517738
RPL12 ribosomal protein L12 -0.0496046
RPS19 ribosomal protein S19 -0.0492504
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0484611
TPT1 tumor protein, translationally-controlled 1 -0.0475654
RPS8 ribosomal protein S8 -0.0468157
DST dystonin -0.0464578
SMYD3 SET and MYND domain containing 3 -0.0458087
PTMA prothymosin, alpha -0.0455523
RPL35A ribosomal protein L35a -0.0448068
COL4A5 collagen, type IV, alpha 5 -0.0445716
POTEF POTE ankyrin domain family, member F -0.0435336
RPS12 ribosomal protein S12 -0.042892
MT2A metallothionein 2A -0.0410071
RPL9 ribosomal protein L9 -0.0403851
RPS3 ribosomal protein S3 -0.0401751
ACTG1 actin gamma 1 -0.0386875
RPL7A ribosomal protein L7a -0.0373918
RPS24 ribosomal protein S24 -0.0363256
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0356738
RTN1 reticulon 1 -0.0356446
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0353951
RPL36A ribosomal protein L36a -0.0353178
NTN4 netrin 4 -0.0350909
SLC38A2 solute carrier family 38, member 2 -0.0346782
EIF1 eukaryotic translation initiation factor 1 -0.0336303
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0335539
RPL36 ribosomal protein L36 -0.0329904
S100A6 S100 calcium binding protein A6 -0.0321238
RACK1 receptor for activated C kinase 1 -0.0318837
RPLP2 ribosomal protein, large, P2 -0.0316404
RPS27 ribosomal protein S27 -0.0316341
RPL37 ribosomal protein L37 -0.0314898
RPL19 ribosomal protein L19 -0.0311784
RPL34 ribosomal protein L34 -0.0309203
TBCA tubulin folding cofactor A -0.030889
RPS14 ribosomal protein S14 -0.0298021
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0287133
EGR1 early growth response 1 -0.0281881
KYNU kynureninase -0.0275466
RPL23 ribosomal protein L23 -0.0275146
RPS29 ribosomal protein S29 -0.0269883
RPS16 ribosomal protein S16 -0.0268988
RPLP0 ribosomal protein, large, P0 -0.026601
RPL5 ribosomal protein L5 -0.0265598
RPL35 ribosomal protein L35 -0.0259699
HLA-B major histocompatibility complex, class I, B -0.025045
VCL vinculin -0.0250131
ANTXR1 anthrax toxin receptor 1 -0.0248522
TFPI2 tissue factor pathway inhibitor 2 -0.0237287
FNDC3A fibronectin type III domain containing 3A -0.0235105
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0233401
RPS27A ribosomal protein S27a -0.023338
RPS13 ribosomal protein S13 -0.0228513
RPL32 ribosomal protein L32 -0.0228192
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0222592
RPS21 ribosomal protein S21 -0.0220334
RPL28 ribosomal protein L28 -0.0218955
B2M beta-2-microglobulin -0.0218394
WSB1 WD repeat and SOCS box containing 1 -0.0217148
RPL30 ribosomal protein L30 -0.0214224
GNAS GNAS complex locus -0.0212682
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0209813
RPS25 ribosomal protein S25 -0.0208917
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0206642
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0201503
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0201157
HLA-A major histocompatibility complex, class I, A -0.019697
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0196652
RPL11 ribosomal protein L11 -0.019577
EIF5B eukaryotic translation initiation factor 5B -0.0195734
COL8A1 collagen, type VIII, alpha 1 -0.019298
NABP1 nucleic acid binding protein 1 -0.0191137
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0190397
AGTPBP1 ATP/GTP binding protein 1 -0.0190262
ASTN2 astrotactin 2 -0.0189504
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0188835
PFN1 profilin 1 -0.0187555
RPS5 ribosomal protein S5 -0.0187273
RPS28 ribosomal protein S28 -0.0183943
BPTF bromodomain PHD finger transcription factor -0.0182658
RPL27 ribosomal protein L27 -0.0181721
ATP5F1E ATP synthase F1 subunit epsilon -0.018018
NT5C2 5'-nucleotidase, cytosolic II -0.0179206
RPS17 ribosomal protein S17 -0.0177282
RANBP17 RAN binding protein 17 -0.0175221