| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemetrexed_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.106293 |
| PDE10A | phosphodiesterase 10A | 0.102077 |
| TXNRD1 | thioredoxin reductase 1 | 0.0938554 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0916841 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0834434 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0831897 |
| NRG1 | neuregulin 1 | 0.0759354 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0751406 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0736738 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0719792 |
| RBM26 | RNA binding motif protein 26 | 0.0719262 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0704614 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0676505 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0657071 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0642766 |
| SPAG9 | sperm associated antigen 9 | 0.0630359 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0617939 |
| FAM13A | family with sequence similarity 13, member A | 0.0604314 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0600325 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0600265 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0582701 |
| SMAD3 | SMAD family member 3 | 0.0568527 |
| MKI67 | marker of proliferation Ki-67 | 0.056049 |
| BRD4 | bromodomain containing 4 | 0.0560481 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.0548206 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.0544651 |
| SEPTIN9 | septin 9 | 0.0528325 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0526382 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0521993 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0521047 |
| RPLP2 | ribosomal protein, large, P2 | 0.0513202 |
| KIF5B | kinesin family member 5B | 0.0511518 |
| LMO7 | LIM domain 7 | 0.0511435 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0503357 |
| FRYL | FRY-like | 0.0495563 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | 0.0475448 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0475025 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0474657 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0465828 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0457633 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0448767 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0441935 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0438458 |
| TPM3 | tropomyosin 3 | 0.0434114 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0429015 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0423959 |
| FLNA | filamin A, alpha | 0.0419253 |
| JAK1 | Janus kinase 1 | 0.0418718 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0418687 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0418233 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0415688 |
| USP3 | ubiquitin specific peptidase 3 | 0.0414629 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0412405 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0407832 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0405999 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | 0.0404942 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0402579 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0400273 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0400141 |
| ABI1 | abl-interactor 1 | 0.0399878 |
| RPS25 | ribosomal protein S25 | 0.0393778 |
| ADNP | activity-dependent neuroprotector homeobox | 0.039076 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0386791 |
| COPA | coatomer protein complex, subunit alpha | 0.0384778 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0382791 |
| NOP58 | NOP58 ribonucleoprotein | 0.0380875 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0380426 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0378026 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0374034 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0371427 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.035539 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0354315 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0353899 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0348207 |
| LAMA4 | laminin, alpha 4 | 0.0342234 |
| ACTN4 | actinin, alpha 4 | 0.0336668 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.0335686 |
| CCNY | cyclin Y | 0.0335478 |
| TPD52 | tumor protein D52 | 0.0334562 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0330164 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0323531 |
| AFTPH | aftiphilin | 0.0322717 |
| APP | amyloid beta (A4) precursor protein | 0.0321607 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0321025 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.031948 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0318306 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0318116 |
| AHR | aryl hydrocarbon receptor | 0.0310274 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0310108 |
| NAV2 | neuron navigator 2 | 0.0310036 |
| MT2A | metallothionein 2A | 0.0309507 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0308686 |
| RPL37 | ribosomal protein L37 | 0.0305206 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.030454 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0304115 |
| SKAP1 | src kinase associated phosphoprotein 1 | 0.029868 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0296146 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0294123 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0291325 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0289184 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.11557 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.110761 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0993017 |
| EXT1 | exostosin glycosyltransferase 1 | -0.095937 |
| ACTG1 | actin gamma 1 | -0.082328 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0791787 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.075833 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0751988 |
| COL1A1 | collagen, type I, alpha 1 | -0.0744232 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0743032 |
| NDRG1 | N-myc downstream regulated 1 | -0.0724096 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.071834 |
| VMP1 | vacuole membrane protein 1 | -0.0714949 |
| CD44 | CD44 molecule (Indian blood group) | -0.0709715 |
| CD2AP | CD2-associated protein | -0.0703727 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0685236 |
| TENM3 | teneurin transmembrane protein 3 | -0.0665728 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0656476 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0646996 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0631489 |
| LDHA | lactate dehydrogenase A | -0.0630583 |
| FLNB | filamin B, beta | -0.0624248 |
| RPS6 | ribosomal protein S6 | -0.0620872 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0613926 |
| ATP13A3 | ATPase type 13A3 | -0.0613787 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0600795 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0590365 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0585728 |
| MAP4 | microtubule-associated protein 4 | -0.058137 |
| CALU | calumenin | -0.0579635 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0576589 |
| VCL | vinculin | -0.0569752 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0567235 |
| GPC6 | glypican 6 | -0.0566204 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0559071 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0526641 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0519671 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0515789 |
| RBM25 | RNA binding motif protein 25 | -0.0514943 |
| RPLP0 | ribosomal protein, large, P0 | -0.0508556 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0503509 |
| ZNF148 | zinc finger protein 148 | -0.0500467 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0490986 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0482348 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0468825 |
| ENO1 | enolase 1, (alpha) | -0.0468159 |
| B2M | beta-2-microglobulin | -0.0455293 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0451644 |
| NF1 | neurofibromin 1 | -0.0443152 |
| LAMB3 | laminin, beta 3 | -0.0432768 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0420978 |
| NBAS | neuroblastoma amplified sequence | -0.0416918 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0404964 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0403762 |
| GNAS | GNAS complex locus | -0.0400722 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0400062 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0389653 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0383509 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0371532 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0364715 |
| AHNAK | AHNAK nucleoprotein | -0.0354566 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0350038 |
| RPL19 | ribosomal protein L19 | -0.0344136 |
| RPL35A | ribosomal protein L35a | -0.0343116 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0341602 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0335966 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.032956 |
| INHBA | inhibin, beta A | -0.0329355 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0326768 |
| CLTC | clathrin, heavy chain (Hc) | -0.0324541 |
| MATR3 | matrin 3 | -0.031827 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0312297 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0309912 |
| MYO10 | myosin X | -0.0306401 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0304438 |
| RPS17 | ribosomal protein S17 | -0.0299285 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0294998 |
| USP34 | ubiquitin specific peptidase 34 | -0.0289571 |
| RLF | rearranged L-myc fusion | -0.0287404 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0280181 |
| PTK2 | protein tyrosine kinase 2 | -0.0278383 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0278016 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.027153 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.027075 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0269065 |
| RPS12 | ribosomal protein S12 | -0.0267207 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0267145 |
| FAT1 | FAT atypical cadherin 1 | -0.0259755 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0254992 |
| MED13 | mediator complex subunit 13 | -0.0253436 |
| PEG10 | paternally expressed 10 | -0.02508 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0245504 |
| GOLGA4 | golgin A4 | -0.0242732 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0241968 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.023883 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.023742 |
| SMYD3 | SET and MYND domain containing 3 | -0.0236438 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0233483 |
| MMP1 | matrix metallopeptidase 1 | -0.0233437 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0233343 |
