| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemetrexed_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| THBS1 | thrombospondin 1 | 0.158626 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.14776 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.140731 |
| TMSB4X | thymosin beta 4, X-linked | 0.112492 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.106308 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.10278 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0993531 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0725647 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0644858 |
| COL3A1 | collagen, type III, alpha 1 | 0.0633597 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0565161 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0555387 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0528788 |
| CFL2 | cofilin 2 (muscle) | 0.0512767 |
| TPM3 | tropomyosin 3 | 0.0466084 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0464051 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0455858 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0452739 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.044541 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0441567 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.04336 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0429924 |
| MATR3 | matrin 3 | 0.0424039 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.040804 |
| NCKAP1 | NCK-associated protein 1 | 0.040668 |
| MKI67 | marker of proliferation Ki-67 | 0.0403427 |
| UPP1 | uridine phosphorylase 1 | 0.0391199 |
| APP | amyloid beta (A4) precursor protein | 0.0391176 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0379938 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0379668 |
| SET | SET nuclear proto-oncogene | 0.0370226 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0349934 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0348719 |
| FLNA | filamin A, alpha | 0.0346161 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0342585 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0342359 |
| ANXA1 | annexin A1 | 0.0339467 |
| H1-4 | H1.4 linker histone, cluster member | 0.033901 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0335254 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0333952 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0332803 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0331333 |
| CANX | calnexin | 0.0320702 |
| VIM | vimentin | 0.0320194 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0317928 |
| CORO1C | coronin, actin binding protein, 1C | 0.0316688 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0312368 |
| SERINC1 | serine incorporator 1 | 0.0307933 |
| NONO | non-POU domain containing, octamer-binding | 0.0307672 |
| C1QBP | complement component 1, q subcomponent binding protein | 0.0304427 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0302556 |
| EMP1 | epithelial membrane protein 1 | 0.0299236 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0291889 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0287747 |
| YME1L1 | YME1-like 1 ATPase | 0.0287041 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0286812 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0286527 |
| SCRN1 | secernin 1 | 0.0281806 |
| MITF | microphthalmia-associated transcription factor | 0.0277395 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0277195 |
| DST | dystonin | 0.0276203 |
| H1-2 | H1.2 linker histone, cluster member | 0.0274907 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0269866 |
| ENAH | enabled homolog (Drosophila) | 0.0269002 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0267575 |
| PNN | pinin, desmosome associated protein | 0.0266363 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0263804 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0260595 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | 0.0260301 |
| ABI2 | abl-interactor 2 | 0.026014 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.025866 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0257956 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0257209 |
| GASK1B | golgi associated kinase 1B | 0.0253887 |
| RPS15A | ribosomal protein S15a | 0.0253816 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0252833 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0251429 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0248086 |
| GPC4 | glypican 4 | 0.0247426 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0246343 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.024568 |
| WDR43 | WD repeat domain 43 | 0.0243305 |
| LRRC59 | leucine rich repeat containing 59 | 0.0242675 |
| SACS | sacsin molecular chaperone | 0.0238643 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 0.0237884 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0236193 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.0235516 |
| WDR33 | WD repeat domain 33 | 0.0235478 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0235392 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0235059 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.0227875 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0225995 |
| ZNF146 | zinc finger protein 146 | 0.0225591 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0225129 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0224738 |
| SART1 | squamous cell carcinoma antigen recognized by T cells | 0.0222591 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0222564 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.022246 |
| RPL3 | ribosomal protein L3 | 0.0222195 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0221427 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.15805 |
| CADM2 | cell adhesion molecule 2 | -0.122646 |
| TMSB10 | thymosin beta 10 | -0.0995913 |
| RPLP1 | ribosomal protein, large, P1 | -0.0856519 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0801517 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0797611 |
| PFN1 | profilin 1 | -0.0724737 |
| RPS8 | ribosomal protein S8 | -0.0690383 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0682927 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.063949 |
| RPL35A | ribosomal protein L35a | -0.0631609 |
| RPS6 | ribosomal protein S6 | -0.0620137 |
| GNAS | GNAS complex locus | -0.0588029 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0567282 |
| POTEF | POTE ankyrin domain family, member F | -0.0539096 |
| RAD51B | RAD51 paralog B | -0.0534449 |
| PHIP | pleckstrin homology domain interacting protein | -0.0532791 |
| PRTG | protogenin | -0.0509136 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0505606 |
| PRKD1 | protein kinase D1 | -0.0505047 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0505024 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0504111 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0491249 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.049101 |
| RPS16 | ribosomal protein S16 | -0.0490731 |
| HMGB1 | high mobility group box 1 | -0.0481103 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0473812 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0459836 |
| RPS19 | ribosomal protein S19 | -0.0448145 |
| HSPB1 | heat shock 27kDa protein 1 | -0.044594 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0445121 |
| SETD5 | SET domain containing 5 | -0.0443713 |
| FBXO11 | F-box protein 11 | -0.0438649 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.043483 |
| FTL | ferritin, light polypeptide | -0.0431316 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0412282 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0410448 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0409282 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0394144 |
| MED13L | mediator complex subunit 13-like | -0.03939 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0393729 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0388179 |
| RPLP0 | ribosomal protein, large, P0 | -0.0382648 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0378466 |
| RPL23 | ribosomal protein L23 | -0.0378453 |
| ENO1 | enolase 1, (alpha) | -0.0372606 |
| RPL12 | ribosomal protein L12 | -0.0369777 |
| RPLP2 | ribosomal protein, large, P2 | -0.0363698 |
| RPS13 | ribosomal protein S13 | -0.0363157 |
| PRR16 | proline rich 16 | -0.0347248 |
| RPL30 | ribosomal protein L30 | -0.0346218 |
| SRP54 | signal recognition particle 54kDa | -0.0345927 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0345508 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0342871 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0338721 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0336514 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.033594 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0332658 |
| MPG | N-methylpurine-DNA glycosylase | -0.0329578 |
| NTM | neurotrimin | -0.0328379 |
| RPL34 | ribosomal protein L34 | -0.0326798 |
| RACK1 | receptor for activated C kinase 1 | -0.0326066 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0325756 |
| RPL28 | ribosomal protein L28 | -0.0325415 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0325108 |
| USP34 | ubiquitin specific peptidase 34 | -0.0322185 |
| NRG1 | neuregulin 1 | -0.0321921 |
| NCOA2 | nuclear receptor coactivator 2 | -0.032092 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0320581 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0317291 |
| THOC2 | THO complex 2 | -0.0311807 |
| RBM25 | RNA binding motif protein 25 | -0.0310714 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0307938 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0305644 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0301081 |
| MAP1B | microtubule-associated protein 1B | -0.0300683 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0300376 |
| FOXP2 | forkhead box P2 | -0.029992 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.029936 |
| ATXN2 | ataxin 2 | -0.0297628 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0296497 |
| NOP58 | NOP58 ribonucleoprotein | -0.0296239 |
| CUX1 | cut-like homeobox 1 | -0.0292821 |
| RPS14 | ribosomal protein S14 | -0.0292555 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0289551 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0287819 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.0285493 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0284595 |
| PARD3 | par-3 family cell polarity regulator | -0.0282451 |
| ITGAV | integrin, alpha V | -0.0282161 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0280823 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.0278982 |
| RPL37A | ribosomal protein L37a | -0.0278708 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0278018 |
| MEIS2 | Meis homeobox 2 | -0.0275506 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0274276 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0273392 |
| TUT4 | terminal uridylyl transferase 4 | -0.0273202 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0272824 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0272103 |
