| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemetrexed_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.145605 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.140652 |
| TMSB4X | thymosin beta 4, X-linked | 0.137255 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.11396 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.104591 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0932208 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0826658 |
| ZNF292 | zinc finger protein 292 | 0.0804002 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0791943 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0782399 |
| GOLGA4 | golgin A4 | 0.0752798 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0723106 |
| EZR | ezrin | 0.0717264 |
| PGK1 | phosphoglycerate kinase 1 | 0.0714911 |
| PTMA | prothymosin, alpha | 0.0654374 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0609774 |
| FLNB | filamin B, beta | 0.0566861 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0557172 |
| RNF145 | ring finger protein 145 | 0.0556947 |
| LDHA | lactate dehydrogenase A | 0.053457 |
| TXNRD1 | thioredoxin reductase 1 | 0.0529937 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0506604 |
| XPO1 | exportin 1 | 0.0502102 |
| S100A6 | S100 calcium binding protein A6 | 0.0500627 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0492855 |
| HDLBP | high density lipoprotein binding protein | 0.049191 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.046655 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0453168 |
| TXNIP | thioredoxin interacting protein | 0.0447313 |
| RBM39 | RNA binding motif protein 39 | 0.0438712 |
| JMJD1C | jumonji domain containing 1C | 0.0434676 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0433013 |
| NUP58 | nucleoporin 58 | 0.0425925 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0405574 |
| MATR3 | matrin 3 | 0.0396685 |
| APP | amyloid beta (A4) precursor protein | 0.0391877 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0391089 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0380919 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0380284 |
| RPL4 | ribosomal protein L4 | 0.036731 |
| NCKAP1 | NCK-associated protein 1 | 0.0356497 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0355648 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.035549 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0354618 |
| RTN4 | reticulon 4 | 0.0354066 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0352097 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0348863 |
| CDC73 | cell division cycle 73 | 0.0346546 |
| TFG | TRK-fused gene | 0.0345796 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0345151 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0339374 |
| USP3 | ubiquitin specific peptidase 3 | 0.0338193 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0337001 |
| TMEM41B | transmembrane protein 41B | 0.0335719 |
| YME1L1 | YME1-like 1 ATPase | 0.0326449 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0326319 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0323917 |
| PYGB | phosphorylase, glycogen; brain | 0.0323727 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0323052 |
| QKI | QKI, KH domain containing, RNA binding | 0.0320496 |
| AHNAK | AHNAK nucleoprotein | 0.0315318 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0313214 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0311507 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0310472 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0300842 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0299032 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0298246 |
| B2M | beta-2-microglobulin | 0.0296868 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0291858 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0290531 |
| COG5 | component of oligomeric golgi complex 5 | 0.0289472 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0288689 |
| CALR | calreticulin | 0.0287677 |
| OGA | O-GlcNAcase | 0.0287428 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0286739 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0279665 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0278901 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0278526 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0277053 |
| COPA | coatomer protein complex, subunit alpha | 0.0274182 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0274112 |
| SETD5 | SET domain containing 5 | 0.0273818 |
| ANK2 | ankyrin 2, neuronal | 0.0273469 |
| NBAS | neuroblastoma amplified sequence | 0.0270544 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0269945 |
| CCNL1 | cyclin L1 | 0.0265782 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0264971 |
| UBC | ubiquitin C | 0.026404 |
| CANX | calnexin | 0.0263033 |
| RHOA | ras homolog family member A | 0.0262259 |
| YTHDC1 | YTH domain containing 1 | 0.0262083 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0261661 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0260427 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0260223 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0259373 |
| ABHD12 | abhydrolase domain containing 12 | 0.0256189 |
| RLF | rearranged L-myc fusion | 0.0251956 |
| RPL3 | ribosomal protein L3 | 0.0251952 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0251902 |
| ADAR | adenosine deaminase, RNA-specific | 0.0249414 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.116182 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0935146 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0919309 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0813569 |
| FOXP1 | forkhead box P1 | -0.0581306 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0509104 |
| GLI3 | GLI family zinc finger 3 | -0.0491495 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0482004 |
| NBEA | neurobeachin | -0.0471203 |
| BMP10 | bone morphogenetic protein 10 | -0.0466259 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0436387 |
| RPL35A | ribosomal protein L35a | -0.043366 |
| NAV2 | neuron navigator 2 | -0.039152 |
| RPS8 | ribosomal protein S8 | -0.0373912 |
| RPL31 | ribosomal protein L31 | -0.0361194 |
| RPL9 | ribosomal protein L9 | -0.035271 |
| DIAPH3 | diaphanous-related formin 3 | -0.0340956 |
| ACTG1 | actin gamma 1 | -0.0317653 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0300303 |
| EGFR | epidermal growth factor receptor | -0.0293161 |
| POTEF | POTE ankyrin domain family, member F | -0.0287785 |
| INTS6 | integrator complex subunit 6 | -0.0286382 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0283746 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0281025 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0269686 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0265469 |
| GLI2 | GLI family zinc finger 2 | -0.0257685 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0256565 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.0255969 |
| EFNA5 | ephrin-A5 | -0.0254373 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0247533 |
| CENPE | centromere protein E, 312kDa | -0.024745 |
| CEP112 | centrosomal protein 112kDa | -0.0235618 |
| BPTF | bromodomain PHD finger transcription factor | -0.0234043 |
| VIM | vimentin | -0.0233075 |
| TMSB10 | thymosin beta 10 | -0.0231584 |
| MACROD2 | MACRO domain containing 2 | -0.0230845 |
| RPS6 | ribosomal protein S6 | -0.0228464 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.022772 |
| TBCA | tubulin folding cofactor A | -0.0220178 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.0219999 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | -0.0219256 |
| CUX1 | cut-like homeobox 1 | -0.0217851 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0217787 |
| AEBP2 | AE binding protein 2 | -0.0217722 |
| PDE7B | phosphodiesterase 7B | -0.0217688 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0215667 |
| MYO5C | myosin VC | -0.0213177 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.021179 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0208432 |
| RPL37A | ribosomal protein L37a | -0.0205499 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0202138 |
| ITGA10 | integrin, alpha 10 | -0.0195878 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | -0.0193797 |
| RPS13 | ribosomal protein S13 | -0.0187295 |
| APLF | aprataxin and PNKP like factor | -0.018691 |
| COMMD10 | COMM domain containing 10 | -0.0183435 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.0182603 |
| RPS25 | ribosomal protein S25 | -0.0181487 |
| PKP4 | plakophilin 4 | -0.0178282 |
| PDE10A | phosphodiesterase 10A | -0.0178205 |
| CCND1 | cyclin D1 | -0.0175354 |
| CENPF | centromere protein F, 350/400kDa | -0.0174262 |
| AFG2A | AFG2 AAA ATPase homolog A | -0.0173801 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0172544 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0172098 |
| GSE1 | Gse1 coiled-coil protein | -0.0171211 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.017112 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0170339 |
| ZMYM4 | zinc finger, MYM-type 4 | -0.0168825 |
| RPLP1 | ribosomal protein, large, P1 | -0.0167691 |
| FNIP1 | folliculin interacting protein 1 | -0.0165411 |
| RPS29 | ribosomal protein S29 | -0.0165286 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0164058 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0163396 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0161781 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0161496 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0160599 |
| RPS14 | ribosomal protein S14 | -0.0160511 |
| RPS27 | ribosomal protein S27 | -0.015884 |
| EXOC4 | exocyst complex component 4 | -0.0158239 |
| RPS15 | ribosomal protein S15 | -0.0157221 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0155359 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0154176 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.0152973 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0152897 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0151029 |
| RPL34 | ribosomal protein L34 | -0.015043 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0149373 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0148325 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0148131 |
| HDAC9 | histone deacetylase 9 | -0.0145277 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0144869 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0143346 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0143221 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0143116 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0140623 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0140498 |
| EBNA1BP2 | EBNA1 binding protein 2 | -0.0140339 |
| PMM2 | phosphomannomutase 2 | -0.014033 |
