| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pemetrexed_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.195099 |
| COL6A3 | collagen, type VI, alpha 3 | 0.101207 |
| FAM13A | family with sequence similarity 13, member A | 0.0860927 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0709282 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0672994 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0590876 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0571822 |
| ARRDC3 | arrestin domain containing 3 | 0.0568656 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0543499 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0536538 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0535075 |
| PTMA | prothymosin, alpha | 0.0493716 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0484618 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0460645 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0458438 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0442071 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0420445 |
| RBM39 | RNA binding motif protein 39 | 0.0406913 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0405063 |
| FLNB | filamin B, beta | 0.0396825 |
| TXNIP | thioredoxin interacting protein | 0.0377532 |
| MSN | moesin | 0.0376286 |
| MATR3 | matrin 3 | 0.0373933 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0371949 |
| PKM | pyruvate kinase, muscle | 0.0367336 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0366898 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0356934 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0351651 |
| COL1A1 | collagen, type I, alpha 1 | 0.034777 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0340265 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0339227 |
| FLNA | filamin A, alpha | 0.0335505 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0334415 |
| ACTN4 | actinin, alpha 4 | 0.0332046 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0330775 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0324888 |
| AFAP1 | actin filament associated protein 1 | 0.0321862 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0320355 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0319201 |
| VIM | vimentin | 0.0317922 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0317213 |
| FBXO32 | F-box protein 32 | 0.0314309 |
| HMGA1 | high mobility group AT-hook 1 | 0.0313679 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0311723 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0310118 |
| COL1A2 | collagen, type I, alpha 2 | 0.0309865 |
| UBAP1 | ubiquitin associated protein 1 | 0.0303649 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0302687 |
| INHBA | inhibin, beta A | 0.0302432 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0301605 |
| ZNF638 | zinc finger protein 638 | 0.0300249 |
| WTAP | Wilms tumor 1 associated protein | 0.0298546 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0296867 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0296766 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0296042 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0295303 |
| TLK1 | tousled-like kinase 1 | 0.0293084 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0290233 |
| USP3 | ubiquitin specific peptidase 3 | 0.0288382 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0284758 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0281841 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0278332 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.0276282 |
| KLC1 | kinesin light chain 1 | 0.0276014 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0273651 |
| TFG | TRK-fused gene | 0.0273411 |
| RNF24 | ring finger protein 24 | 0.0273246 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0271325 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0270492 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0268656 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0267857 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0266642 |
| TMEM245 | transmembrane protein 245 | 0.0266218 |
| TET2 | tet methylcytosine dioxygenase 2 | 0.0264672 |
| RPL7 | ribosomal protein L7 | 0.0264518 |
| PDE10A | phosphodiesterase 10A | 0.0261407 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0260613 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.0258025 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0257993 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0256481 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.025553 |
| RPL23 | ribosomal protein L23 | 0.025213 |
| SLMAP | sarcolemma associated protein | 0.0251793 |
| NDRG1 | N-myc downstream regulated 1 | 0.0251304 |
| BBX | bobby sox homolog (Drosophila) | 0.0250925 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0249272 |
| MEF2A | myocyte enhancer factor 2A | 0.0248849 |
| IGF2 | insulin-like growth factor 2 | 0.0248399 |
| ATP13A3 | ATPase type 13A3 | 0.024642 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0245913 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0245145 |
| COL5A2 | collagen, type V, alpha 2 | 0.0245087 |
| APOB | apolipoprotein B | 0.0243941 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0243824 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0243803 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0243194 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0243191 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0243185 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0242439 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0242374 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.176559 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.160459 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.125248 |
| LOX | lysyl oxidase | -0.111176 |
| HMGA2 | high mobility group AT-hook 2 | -0.108332 |
| HLA-B | major histocompatibility complex, class I, B | -0.0986251 |
| SDC4 | syndecan 4 | -0.0971241 |
| CDH13 | cadherin 13 | -0.0923744 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0905306 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0901735 |
| FN1 | fibronectin 1 | -0.0896472 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0894341 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0763101 |
| EGFR | epidermal growth factor receptor | -0.0716448 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0697419 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0678403 |
| IL6 | interleukin 6 | -0.0649521 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0598672 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0595498 |
| RAI14 | retinoic acid induced 14 | -0.0577222 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0574329 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0547516 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0545007 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0535418 |
| CD44 | CD44 molecule (Indian blood group) | -0.0533827 |
| COL5A1 | collagen, type V, alpha 1 | -0.0511339 |
| VCL | vinculin | -0.0508035 |
| CDK13 | cyclin-dependent kinase 13 | -0.0502222 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0497902 |
| FBXO11 | F-box protein 11 | -0.0494326 |
| STC1 | stanniocalcin 1 | -0.0487721 |
| HDLBP | high density lipoprotein binding protein | -0.0486371 |
| AHNAK | AHNAK nucleoprotein | -0.0485395 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0482714 |
| FNIP1 | folliculin interacting protein 1 | -0.0481895 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0477247 |
| TPM4 | tropomyosin 4 | -0.0475147 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0473268 |
| GOLGA4 | golgin A4 | -0.0468924 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0463342 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0457844 |
| INTS6 | integrator complex subunit 6 | -0.0453249 |
| ATXN1 | ataxin 1 | -0.0445424 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0435359 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0426098 |
| TNS3 | tensin 3 | -0.0418198 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0417534 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0396504 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0388232 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0386327 |
| CALU | calumenin | -0.0380495 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0374496 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0373286 |
| GOLGB1 | golgin B1 | -0.0366982 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0366468 |
| COG6 | component of oligomeric golgi complex 6 | -0.036483 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0364609 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0362018 |
| PTGES2 | prostaglandin E synthase 2 | -0.036177 |
| HLA-C | major histocompatibility complex, class I, C | -0.0357273 |
| NBEAL1 | neurobeachin-like 1 | -0.0345468 |
| HM13 | histocompatibility (minor) 13 | -0.034159 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.033398 |
| B2M | beta-2-microglobulin | -0.0332506 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0331817 |
| COL6A1 | collagen, type VI, alpha 1 | -0.033156 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0328377 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.0327974 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0326333 |
| CADM1 | cell adhesion molecule 1 | -0.0319141 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0318104 |
| PRSS23 | protease, serine, 23 | -0.0317753 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0313433 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0309455 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | -0.0306576 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.030535 |
| TBCA | tubulin folding cofactor A | -0.0303822 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0302371 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0302347 |
| CANX | calnexin | -0.0301499 |
| VEGFC | vascular endothelial growth factor C | -0.0299038 |
| MMP12 | matrix metallopeptidase 12 | -0.0297612 |
| SCFD2 | sec1 family domain containing 2 | -0.0296356 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0296138 |
| GLG1 | golgi glycoprotein 1 | -0.0292982 |
| CDK6 | cyclin-dependent kinase 6 | -0.029193 |
| MAP4 | microtubule-associated protein 4 | -0.0287381 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0282399 |
| SEC24D | SEC24 family member D | -0.0281485 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0278921 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0277553 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0276605 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0275406 |
| PPIP5K2 | diphosphoinositol pentakisphosphate kinase 2 | -0.0272121 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0269377 |
| ROS1 | ROS proto-oncogene 1 , receptor tyrosine kinase | -0.0268928 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0266964 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0264918 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0259802 |
| HLA-A | major histocompatibility complex, class I, A | -0.0259388 |
