| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pemetrexed_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DERA | deoxyribose-phosphate aldolase (putative) | 0.0454751 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0382696 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0368309 |
| CEP250 | centrosomal protein 250kDa | 0.0335111 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0320813 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0305589 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0270552 |
| NBAS | neuroblastoma amplified sequence | 0.0267689 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0260099 |
| VIM | vimentin | 0.0249257 |
| PRKCE | protein kinase C, epsilon | 0.0237512 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0226876 |
| ERGIC3 | ERGIC and golgi 3 | 0.0226332 |
| ALKBH5 | AlkB family member 5, RNA demethylase | 0.0224799 |
| FLNA | filamin A, alpha | 0.021882 |
| RPL4 | ribosomal protein L4 | 0.0217941 |
| DSE | dermatan sulfate epimerase | 0.0214741 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0214711 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0206356 |
| JMJD1C | jumonji domain containing 1C | 0.0194914 |
| RPL7 | ribosomal protein L7 | 0.0193997 |
| COPG1 | coatomer protein complex, subunit gamma 1 | 0.0193853 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0193557 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0191991 |
| PRELID2 | PRELI domain containing 2 | 0.0183338 |
| XPO1 | exportin 1 | 0.0180032 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0179832 |
| SH3GL1 | SH3-domain GRB2-like 1 | 0.0179115 |
| CAPRIN2 | caprin family member 2 | 0.0178256 |
| SEPTIN2 | septin 2 | 0.0174671 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0171553 |
| HDLBP | high density lipoprotein binding protein | 0.0168567 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0167586 |
| GPR107 | G protein-coupled receptor 107 | 0.0166134 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0163252 |
| HBP1 | HMG-box transcription factor 1 | 0.0160935 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0160857 |
| TAOK2 | TAO kinase 2 | 0.0158618 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0157213 |
| FBXW2 | F-box and WD repeat domain containing 2 | 0.0156699 |
| OLA1 | Obg-like ATPase 1 | 0.0155054 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0153621 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0152481 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.0152416 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.015232 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0151973 |
| RPL14 | ribosomal protein L14 | 0.0151923 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0149964 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0149649 |
| PIKFYVE | phosphoinositide kinase, FYVE finger containing | 0.014753 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0146757 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0145522 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0144349 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0143392 |
| RBM27 | RNA binding motif protein 27 | 0.0141775 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0141037 |
| YME1L1 | YME1-like 1 ATPase | 0.0136882 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0135615 |
| SEC13 | SEC13 homolog (S. cerevisiae) | 0.0135581 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0134502 |
| POM121 | POM121 transmembrane nucleoporin | 0.0134458 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0134407 |
| UIMC1 | ubiquitin interaction motif containing 1 | 0.0133371 |
| ARRDC3 | arrestin domain containing 3 | 0.0133136 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0131622 |
| SMAD3 | SMAD family member 3 | 0.0131174 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0130886 |
| CLASP2 | cytoplasmic linker associated protein 2 | 0.0130821 |
| RNF213 | ring finger protein 213 | 0.0129636 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0129574 |
| PIK3C3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | 0.0127577 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.0127072 |
| INSIG1 | insulin induced gene 1 | 0.0127035 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0127001 |
| RANBP3 | RAN binding protein 3 | 0.0126984 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | 0.0126406 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.012613 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.012604 |
| RELA | v-rel avian reticuloendotheliosis viral oncogene homolog A | 0.0125312 |
| TMEM214 | transmembrane protein 214 | 0.0123343 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0123202 |
| GTF2F1 | general transcription factor IIF, polypeptide 1, 74kDa | 0.0122789 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0122711 |
| DMXL2 | Dmx-like 2 | 0.0122485 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0122142 |
| MCL1 | myeloid cell leukemia 1 | 0.0122092 |
| INTS2 | integrator complex subunit 2 | 0.0122076 |
| SCFD1 | sec1 family domain containing 1 | 0.0121238 |
| ZBTB25 | zinc finger and BTB domain containing 25 | 0.0120593 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0119791 |
| ANGPTL4 | angiopoietin-like 4 | 0.0119036 |
| WDR20 | WD repeat domain 20 | 0.0118983 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0117926 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.011787 |
| TMEM41B | transmembrane protein 41B | 0.0117328 |
| SEC24A | SEC24 family member A | 0.0117306 |
| STK24 | serine/threonine kinase 24 | 0.0116842 |
| FKBP10 | FK506 binding protein 10, 65 kDa | 0.0116833 |
| ALG9 | ALG9, alpha-1,2-mannosyltransferase | 0.0115844 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | 0.011567 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.287622 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0576874 |
| CENPF | centromere protein F, 350/400kDa | -0.0570521 |
| CD44 | CD44 molecule (Indian blood group) | -0.0522677 |
| RBM39 | RNA binding motif protein 39 | -0.0494788 |
| PTMA | prothymosin, alpha | -0.0475377 |
| TPX2 | TPX2, microtubule-associated | -0.0471808 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0441547 |
| ATM | ATM serine/threonine kinase | -0.0434288 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.042352 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0413757 |
| GOLGA4 | golgin A4 | -0.040737 |
| MT2A | metallothionein 2A | -0.0404414 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0398566 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0393877 |
| YBX3 | Y box binding protein 3 | -0.0382309 |
| ANLN | anillin, actin binding protein | -0.0367234 |
| LDHA | lactate dehydrogenase A | -0.0353185 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0341175 |
| KIF5B | kinesin family member 5B | -0.0331013 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0329656 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0320241 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0310946 |
| SPAG9 | sperm associated antigen 9 | -0.0307669 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.03065 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0301498 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.030087 |
| PHF20 | PHD finger protein 20 | -0.0298766 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0293783 |
| ERBIN | erbb2 interacting protein | -0.0285832 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0285143 |
| TMEM123 | transmembrane protein 123 | -0.0284156 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0281732 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0277915 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0273783 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0270395 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0269328 |
| RDX | radixin | -0.0268257 |
| IGF2 | insulin-like growth factor 2 | -0.0268015 |
| RPLP1 | ribosomal protein, large, P1 | -0.0266944 |
| LMO7 | LIM domain 7 | -0.0266352 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0262795 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0260267 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0259357 |
| MKI67 | marker of proliferation Ki-67 | -0.0258885 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0255531 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.025248 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0250643 |
| SQSTM1 | sequestosome 1 | -0.0250355 |
| PHF3 | PHD finger protein 3 | -0.025015 |
| NBEAL1 | neurobeachin-like 1 | -0.0248419 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0247254 |
| RPL15 | ribosomal protein L15 | -0.0244814 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0241802 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0241675 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0239001 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0237864 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0233007 |
| NAV2 | neuron navigator 2 | -0.0228052 |
| RB1 | retinoblastoma 1 | -0.0224374 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0223417 |
| POTEF | POTE ankyrin domain family, member F | -0.0218594 |
| DST | dystonin | -0.0217947 |
| H3-3B | H3.3 histone B | -0.0216572 |
| PRR11 | proline rich 11 | -0.0215138 |
| DEK | DEK proto-oncogene | -0.0214978 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0213959 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.021203 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0211145 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0210278 |
| NKTR | natural killer cell triggering receptor | -0.0209912 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0209477 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.020749 |
| TMSB10 | thymosin beta 10 | -0.0205066 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0203459 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0201317 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0200853 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0200102 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0199697 |
| DENND4A | DENN/MADD domain containing 4A | -0.0198803 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0197612 |
| FBXO11 | F-box protein 11 | -0.0197385 |
| MATR3 | matrin 3 | -0.0197071 |
| ATG7 | autophagy related 7 | -0.0194224 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.0194203 |
| CPNE1 | copine I | -0.0192645 |
| ACTG1 | actin gamma 1 | -0.0192369 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0191895 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0191853 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0189818 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0189497 |
| TXNRD1 | thioredoxin reductase 1 | -0.0189257 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0188458 |
| KIF4A | kinesin family member 4A | -0.0186252 |
| ZNF638 | zinc finger protein 638 | -0.0185865 |
| IL6ST | interleukin 6 signal transducer | -0.0184806 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -0.0183056 |
| TPR | translocated promoter region, nuclear basket protein | -0.0181967 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0181191 |
| HMGA2 | high mobility group AT-hook 2 | -0.0180887 |
