| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemetrexed perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pemetrexed_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.125045 |
| VIM | vimentin | 0.106683 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.10013 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0985689 |
| CANX | calnexin | 0.0875105 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0839679 |
| MT2A | metallothionein 2A | 0.081961 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0690435 |
| OGA | O-GlcNAcase | 0.0658678 |
| FLNA | filamin A, alpha | 0.0656936 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0635016 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0603516 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0562621 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0545711 |
| VEGFA | vascular endothelial growth factor A | 0.0534432 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0520628 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0512968 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0496005 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0491227 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0486336 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0472131 |
| RPS12 | ribosomal protein S12 | 0.044929 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0438146 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0437232 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0428458 |
| SMAD3 | SMAD family member 3 | 0.0428197 |
| RNF145 | ring finger protein 145 | 0.0411115 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0403291 |
| SMOX | spermine oxidase | 0.0393338 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0376884 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0373399 |
| PGK1 | phosphoglycerate kinase 1 | 0.0370196 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0367256 |
| NEK7 | NIMA-related kinase 7 | 0.0366341 |
| ETNK1 | ethanolamine kinase 1 | 0.0366027 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0365609 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0359238 |
| AHR | aryl hydrocarbon receptor | 0.0349928 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0343346 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0334469 |
| ACTN4 | actinin, alpha 4 | 0.0329775 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0321775 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0319836 |
| APP | amyloid beta (A4) precursor protein | 0.0318246 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0317042 |
| RPL13A | ribosomal protein L13a | 0.03104 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0305466 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0304387 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0303131 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0300064 |
| ARRDC3 | arrestin domain containing 3 | 0.0299873 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0297286 |
| SUCO | SUN domain containing ossification factor | 0.0297176 |
| CALR | calreticulin | 0.0294339 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0293393 |
| RAB8B | RAB8B, member RAS oncogene family | 0.02916 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0289856 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0289106 |
| RPL7 | ribosomal protein L7 | 0.0287784 |
| ZNF292 | zinc finger protein 292 | 0.0286909 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0280244 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0278298 |
| FAT1 | FAT atypical cadherin 1 | 0.0272778 |
| NUP58 | nucleoporin 58 | 0.0271499 |
| RPS19 | ribosomal protein S19 | 0.0270905 |
| PKM | pyruvate kinase, muscle | 0.0270615 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0269799 |
| RPS3 | ribosomal protein S3 | 0.026931 |
| HELZ | helicase with zinc finger | 0.0268394 |
| RPL23 | ribosomal protein L23 | 0.0265057 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0264109 |
| PCBP2 | poly(rC) binding protein 2 | 0.0261553 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0260553 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0260229 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0259559 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0259281 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0257999 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.025798 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0257806 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0257383 |
| GOLGA4 | golgin A4 | 0.0254886 |
| ANLN | anillin, actin binding protein | 0.025398 |
| HDGF | hepatoma-derived growth factor | 0.0252591 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0252505 |
| YBX1 | Y box binding protein 1 | 0.025078 |
| SEPTIN7 | septin 7 | 0.0250075 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0247852 |
| TFG | TRK-fused gene | 0.0247218 |
| CENPF | centromere protein F, 350/400kDa | 0.0246894 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0245855 |
| RPL11 | ribosomal protein L11 | 0.024557 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0244994 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.024403 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0242561 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0241378 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0241204 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0237962 |
| PNN | pinin, desmosome associated protein | 0.0237086 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0232358 |
| SERINC1 | serine incorporator 1 | 0.0231812 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.268896 |
| HMGA2 | high mobility group AT-hook 2 | -0.132059 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.111494 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0876011 |
| SQSTM1 | sequestosome 1 | -0.0828784 |
| ITGA1 | integrin, alpha 1 | -0.0821185 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0755629 |
| SYT1 | synaptotagmin I | -0.0720904 |
| FN1 | fibronectin 1 | -0.0703468 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0650745 |
| RAI14 | retinoic acid induced 14 | -0.0567036 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0562401 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0521685 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0513278 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0501165 |
| ACTG1 | actin gamma 1 | -0.0490892 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0480762 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0472786 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0453606 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0436527 |
| HLA-B | major histocompatibility complex, class I, B | -0.043212 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0429702 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.04277 |
| EFNA5 | ephrin-A5 | -0.0411909 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0393338 |
| POTEF | POTE ankyrin domain family, member F | -0.0370371 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0369726 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0365658 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0343755 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0343475 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0342504 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0340489 |
| AEBP2 | AE binding protein 2 | -0.0336461 |
| LMNA | lamin A/C | -0.0334889 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0333492 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0333208 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0324945 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0324108 |
| S100A6 | S100 calcium binding protein A6 | -0.0318807 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0316511 |
| TMSB10 | thymosin beta 10 | -0.030967 |
| TENM4 | teneurin transmembrane protein 4 | -0.0302525 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0302065 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0301699 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0299604 |
| INTS6 | integrator complex subunit 6 | -0.0292529 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0288078 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0281896 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0275002 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0274394 |
| STC2 | stanniocalcin 2 | -0.0274069 |
| CDK13 | cyclin-dependent kinase 13 | -0.026479 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0263884 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0260972 |
| ASPH | aspartate beta-hydroxylase | -0.0259628 |
| FBN1 | fibrillin 1 | -0.0259435 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.02583 |
| EGR1 | early growth response 1 | -0.0258037 |
| PALLD | palladin, cytoskeletal associated protein | -0.0253339 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.025153 |
| BPTF | bromodomain PHD finger transcription factor | -0.0248627 |
| TMSB4X | thymosin beta 4, X-linked | -0.0244281 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0239618 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0237585 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.0235103 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0234294 |
| RASAL2 | RAS protein activator like 2 | -0.0231312 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.023073 |
| CADM1 | cell adhesion molecule 1 | -0.02297 |
| DUSP6 | dual specificity phosphatase 6 | -0.0227814 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0222301 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0219224 |
| RANBP17 | RAN binding protein 17 | -0.0219149 |
| RPL35A | ribosomal protein L35a | -0.0218649 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.021829 |
| TGFA | transforming growth factor, alpha | -0.0216152 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0215412 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0213479 |
| MMP13 | matrix metallopeptidase 13 | -0.0212254 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0212002 |
| TMEM156 | transmembrane protein 156 | -0.0211353 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0207056 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.020659 |
| CUX1 | cut-like homeobox 1 | -0.0205519 |
| USP34 | ubiquitin specific peptidase 34 | -0.0201045 |
| RNF213 | ring finger protein 213 | -0.0199214 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0197969 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0197481 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0196402 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0196157 |
| TCIM | transcriptional and immune response regulator | -0.0195522 |
| GLIS3 | GLIS family zinc finger 3 | -0.0195224 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.0195064 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0194058 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0194028 |
| IER3 | immediate early response 3 | -0.0193646 |
| PLIN2 | perilipin 2 | -0.0193075 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0191416 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0190257 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0189483 |
