Pemigatinib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pemigatinib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pemigatinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.189391
IGFBP3 insulin-like growth factor binding protein 3 0.154302
TRIO trio Rho guanine nucleotide exchange factor 0.148057
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0878178
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0816468
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0780237
LDHA lactate dehydrogenase A 0.0661394
FNDC3B fibronectin type III domain containing 3B 0.0604021
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0603754
BHLHE40 basic helix-loop-helix family, member e40 0.0584687
MAP1B microtubule-associated protein 1B 0.053667
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0515567
CD44 CD44 molecule (Indian blood group) 0.0509633
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0494434
HDAC9 histone deacetylase 9 0.0493681
RUNX1 runt-related transcription factor 1 0.0485926
TLE4 transducin-like enhancer of split 4 0.0479527
COL8A1 collagen, type VIII, alpha 1 0.0478716
FLNB filamin B, beta 0.0435298
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0391489
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0383246
GPC6 glypican 6 0.0381696
DLG1 discs, large homolog 1 (Drosophila) 0.0375544
RTN4 reticulon 4 0.036983
SEPTIN9 septin 9 0.0368478
ADAM9 ADAM metallopeptidase domain 9 0.0362955
POTEF POTE ankyrin domain family, member F 0.03576
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0356
SLIT2 slit homolog 2 (Drosophila) 0.0352834
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0346805
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0346471
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0339895
PKM pyruvate kinase, muscle 0.0338758
MSN moesin 0.0332942
CLIC4 chloride intracellular channel 4 0.0332126
ZEB1 zinc finger E-box binding homeobox 1 0.032755
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0319017
ATP13A3 ATPase type 13A3 0.0314287
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0313096
MB21D2 Mab-21 domain containing 2 0.0312417
C1D C1D nuclear receptor corepressor 0.030974
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0305946
PRELID2 PRELI domain containing 2 0.0303704
TPM3 tropomyosin 3 0.0302381
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0298927
GLIS3 GLIS family zinc finger 3 0.0296485
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0294233
ZNF148 zinc finger protein 148 0.0293723
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0287369
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.027005
SHB Src homology 2 domain containing adaptor protein B 0.0264748
FBXL7 F-box and leucine-rich repeat protein 7 0.0263996
ZMIZ1 zinc finger, MIZ-type containing 1 0.025638
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0255817
RHOBTB3 Rho-related BTB domain containing 3 0.0255527
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0254111
PDIA3 protein disulfide isomerase family A, member 3 0.0253335
LAMB1 laminin, beta 1 0.0253112
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0251163
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.024615
USP9X ubiquitin specific peptidase 9, X-linked 0.02458
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0244712
PPARD peroxisome proliferator-activated receptor delta 0.0244375
KDM2A lysine (K)-specific demethylase 2A 0.0243875
DCLK2 doublecortin-like kinase 2 0.0241114
PCBP2 poly(rC) binding protein 2 0.0240497
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0239726
CTBP2 C-terminal binding protein 2 0.0239339
ARRDC3 arrestin domain containing 3 0.0239301
MYOF myoferlin 0.0238361
LOC112694756 uncharaterized LOC112694756 0.0236938
CD59 CD59 molecule, complement regulatory protein 0.0235731
LHFPL6 LHFPL tetraspan subfamily member 6 0.0233961
SON SON DNA binding protein 0.0232912
ACER3 alkaline ceramidase 3 0.0231884
ASPH aspartate beta-hydroxylase 0.0229583
SOX9 SRY (sex determining region Y)-box 9 0.0227452
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0226829
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0226532
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.022592
HELZ helicase with zinc finger 0.0222892
CRYBG3 beta-gamma crystallin domain containing 3 0.0222523
UBA6 ubiquitin-like modifier activating enzyme 6 0.0221114
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0218716
PTK2 protein tyrosine kinase 2 0.02186
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0217372
BRD2 bromodomain containing 2 0.0216515
ZNF638 zinc finger protein 638 0.0214016
GOLIM4 golgi integral membrane protein 4 0.0213139
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 0.0209548
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0209061
SMYD3 SET and MYND domain containing 3 0.0208835
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0208111
MAP4 microtubule-associated protein 4 0.020399
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0202
TGFB1 transforming growth factor, beta 1 0.0199317
ANO6 anoctamin 6 0.0198026
VEGFC vascular endothelial growth factor C 0.0197729
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0197575
FNIP2 folliculin interacting protein 2 0.0196411

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.352608
VIM vimentin -0.183166
AKAP12 A kinase (PRKA) anchor protein 12 -0.177899
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0893628
MT2A metallothionein 2A -0.0864452
AHNAK AHNAK nucleoprotein -0.0845389
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0766114
CANX calnexin -0.0709777
PLAT plasminogen activator, tissue -0.0674362
S100A6 S100 calcium binding protein A6 -0.0666382
TPT1 tumor protein, translationally-controlled 1 -0.0658869
TMSB10 thymosin beta 10 -0.0588993
HLA-B major histocompatibility complex, class I, B -0.0582285
CSTB cystatin B (stefin B) -0.0563613
PTMA prothymosin, alpha -0.0495274
TM4SF1 transmembrane 4 L six family member 1 -0.0464839
CAVIN1 caveolae associated protein 1 -0.0440171
ABI3BP ABI family, member 3 (NESH) binding protein -0.040731
FN1 fibronectin 1 -0.0404111
RPL35A ribosomal protein L35a -0.0398113
NDRG1 N-myc downstream regulated 1 -0.039129
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0390297
TPM4 tropomyosin 4 -0.0379616
SQSTM1 sequestosome 1 -0.0371247
COL3A1 collagen, type III, alpha 1 -0.0366906
LMNA lamin A/C -0.0351645
GOLGB1 golgin B1 -0.0350967
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0342945
RPS24 ribosomal protein S24 -0.0342398
DGKG diacylglycerol kinase, gamma 90kDa -0.0324286
AHNAK2 AHNAK nucleoprotein 2 -0.0317952
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0293121
SAMD9 sterile alpha motif domain containing 9 -0.0292855
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0288509
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0284554
RPS8 ribosomal protein S8 -0.0284264
SLFN5 schlafen family member 5 -0.0282477
HLA-E major histocompatibility complex, class I, E -0.027874
HLA-C major histocompatibility complex, class I, C -0.0270091
RPS27A ribosomal protein S27a -0.0268174
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0264339
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0260614
FRMD4A FERM domain containing 4A -0.0258126
SORBS2 sorbin and SH3 domain containing 2 -0.0248727
GNAS GNAS complex locus -0.0247447
ACTG1 actin gamma 1 -0.0244726
GCC2 GRIP and coiled-coil domain containing 2 -0.0241058
RPL37A ribosomal protein L37a -0.0238742
CCND1 cyclin D1 -0.023587
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0229968
SUCNR1 succinate receptor 1 -0.0224643
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0224166
PRSS23 protease, serine, 23 -0.022379
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0223592
RPL31 ribosomal protein L31 -0.0221657
RPLP1 ribosomal protein, large, P1 -0.0219293
BTG1 B-cell translocation gene 1, anti-proliferative -0.021701
LOX lysyl oxidase -0.0216647
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.021648
FTL ferritin, light polypeptide -0.0211659
STC1 stanniocalcin 1 -0.0211252
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0210818
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0209106
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0209084
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.019985
SH3KBP1 SH3-domain kinase binding protein 1 -0.0198668
IFI6 interferon, alpha-inducible protein 6 -0.0197397
THBS2 thrombospondin 2 -0.0194001
SASH1 SAM and SH3 domain containing 1 -0.019358
ZMYND8 zinc finger, MYND-type containing 8 -0.0189212
RPL34 ribosomal protein L34 -0.0186941
RACK1 receptor for activated C kinase 1 -0.0186928
RPL9 ribosomal protein L9 -0.0186166
DPYSL2 dihydropyrimidinase-like 2 -0.0185347
AFF3 AF4/FMR2 family, member 3 -0.018366
SLC38A1 solute carrier family 38, member 1 -0.0180536
FBN1 fibrillin 1 -0.0179111
PLXNA2 plexin A2 -0.0178838
GDF15 growth differentiation factor 15 -0.0176985
SOD2 superoxide dismutase 2, mitochondrial -0.0176893
RPL37 ribosomal protein L37 -0.0176415
S100A4 S100 calcium binding protein A4 -0.0175091
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0174416
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0172293
RPS13 ribosomal protein S13 -0.0171993
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0171827
SFTPA2 surfactant protein A2 -0.0169727
MRPS6 mitochondrial ribosomal protein S6 -0.0169675
NIBAN1 niban apoptosis regulator 1 -0.0168057
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.01671
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.0166985
FGFR1 fibroblast growth factor receptor 1 -0.0166694
SDK1 sidekick cell adhesion molecule 1 -0.0165827
CALR calreticulin -0.0165331
OPTN optineurin -0.0163831
RPL12 ribosomal protein L12 -0.0163691
POMP proteasome maturation protein -0.0163053
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0162576
RPL38 ribosomal protein L38 -0.0162335
PRMT2 protein arginine methyltransferase 2 -0.0162081