| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemigatinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pemigatinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.198818 |
| NLGN1 | neuroligin 1 | 0.148095 |
| HMGA2 | high mobility group AT-hook 2 | 0.12735 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0907532 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.085997 |
| EHBP1 | EH domain binding protein 1 | 0.08309 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0820892 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0794211 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0781578 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0754495 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0753541 |
| INTS6 | integrator complex subunit 6 | 0.0734022 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.072771 |
| VMP1 | vacuole membrane protein 1 | 0.0711198 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0702833 |
| ASPH | aspartate beta-hydroxylase | 0.065528 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0618926 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0616894 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0556614 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0539353 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0534116 |
| YAP1 | Yes-associated protein 1 | 0.0524554 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0481501 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0478738 |
| PDGFC | platelet derived growth factor C | 0.0474505 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0459995 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0459453 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0458535 |
| RASAL2 | RAS protein activator like 2 | 0.0445964 |
| ANKRD28 | ankyrin repeat domain 28 | 0.044565 |
| MED13L | mediator complex subunit 13-like | 0.0445535 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0435015 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0432476 |
| PARD3 | par-3 family cell polarity regulator | 0.0429725 |
| USP34 | ubiquitin specific peptidase 34 | 0.0419901 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0418105 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0413358 |
| PRKCE | protein kinase C, epsilon | 0.0403099 |
| KIAA1328 | KIAA1328 | 0.0394128 |
| RHOA | ras homolog family member A | 0.0393285 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0393015 |
| METTL15 | methyltransferase like 15 | 0.0385168 |
| MSI2 | musashi RNA-binding protein 2 | 0.0368971 |
| HDAC9 | histone deacetylase 9 | 0.0357808 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0355744 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0353707 |
| GCG | glucagon | 0.035357 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0353483 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0353257 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.0352378 |
| ADAMTSL1 | ADAMTS-like 1 | 0.0349417 |
| SIK3 | SIK family kinase 3 | 0.0349276 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0346055 |
| NFIB | nuclear factor I/B | 0.0344918 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0340495 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.034043 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0339256 |
| ANXA1 | annexin A1 | 0.0335289 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0330323 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0326071 |
| PHF21A | PHD finger protein 21A | 0.0324799 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0319792 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.0319677 |
| PCDH7 | protocadherin 7 | 0.0318795 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0317255 |
| CALR | calreticulin | 0.0317147 |
| FER | fer (fps/fes related) tyrosine kinase | 0.031603 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0314005 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.031026 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0310031 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0309195 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.030827 |
| ELP4 | elongator acetyltransferase complex subunit 4 | 0.03071 |
| RCOR1 | REST corepressor 1 | 0.0307063 |
| R3HDM2 | R3H domain containing 2 | 0.0305873 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0302467 |
| RPL13A | ribosomal protein L13a | 0.0294726 |
| TOP1 | topoisomerase (DNA) I | 0.0293694 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0293251 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0288355 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0283573 |
| BCHE | butyrylcholinesterase | 0.0278561 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0278453 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0276705 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0276243 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0274085 |
| AHNAK | AHNAK nucleoprotein | 0.0272044 |
| TMEM108 | transmembrane protein 108 | 0.0271742 |
| MICU3 | mitochondrial calcium uptake family, member 3 | 0.0271071 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0266476 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0263731 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0263276 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.02604 |
| EXOC4 | exocyst complex component 4 | 0.0258839 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0258364 |
| FHIT | fragile histidine triad | 0.0257534 |
| PRELID2 | PRELI domain containing 2 | 0.0254688 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.025222 |
| MYO1D | myosin ID | 0.0252111 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.025161 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SMC4 | structural maintenance of chromosomes 4 | -0.0555816 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0424701 |
| TMSB10 | thymosin beta 10 | -0.0369365 |
| CENPF | centromere protein F, 350/400kDa | -0.0348779 |
| XPO1 | exportin 1 | -0.034374 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0331359 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0331016 |
| MKI67 | marker of proliferation Ki-67 | -0.032919 |
| RPLP0 | ribosomal protein, large, P0 | -0.0328767 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0327785 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0327398 |
| MATR3 | matrin 3 | -0.0325887 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.030369 |
| MAP1B | microtubule-associated protein 1B | -0.0300506 |
| KIF5B | kinesin family member 5B | -0.0289318 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0283007 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0282268 |
| OXR1 | oxidation resistance 1 | -0.0281073 |
| RPS6 | ribosomal protein S6 | -0.028052 |
| FTL | ferritin, light polypeptide | -0.0276981 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.027588 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0273646 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.0272973 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0272572 |
| PLK2 | polo-like kinase 2 | -0.0265836 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0260289 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0259218 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0257169 |
| KLF6 | Kruppel-like factor 6 | -0.0255798 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0251274 |
| CEP95 | centrosomal protein 95kDa | -0.0247642 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0240102 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0233473 |
| TMEM123 | transmembrane protein 123 | -0.0231897 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0231066 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0224133 |
| TENM3 | teneurin transmembrane protein 3 | -0.0223429 |
| PEG10 | paternally expressed 10 | -0.0223411 |
| AREG | amphiregulin | -0.0221069 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | -0.0217449 |
| ECT2 | epithelial cell transforming 2 | -0.021327 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.0212814 |
| YBX1 | Y box binding protein 1 | -0.0210463 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0209808 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0206904 |
| RBM25 | RNA binding motif protein 25 | -0.0204818 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0203734 |
| SNX13 | sorting nexin 13 | -0.0198357 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0197812 |
| RAB10 | RAB10, member RAS oncogene family | -0.019583 |
| WWOX | WW domain containing oxidoreductase | -0.0193211 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0191712 |
| FUS | FUS RNA binding protein | -0.0190664 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0184023 |
| MGAT4C | MGAT4 family, member C | -0.0184016 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0183834 |
| RPL4 | ribosomal protein L4 | -0.018368 |
| AFG3L2 | AFG3-like AAA ATPase 2 | -0.0181431 |
| NCKAP1 | NCK-associated protein 1 | -0.0180028 |
| JAK1 | Janus kinase 1 | -0.0179939 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0177826 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0176914 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0176646 |
| KLHL24 | kelch-like family member 24 | -0.017653 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0175532 |
| ANXA2 | annexin A2 | -0.017529 |
| CEP192 | centrosomal protein 192kDa | -0.0175091 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.017347 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.017332 |
| RPS24 | ribosomal protein S24 | -0.017316 |
| TPM3 | tropomyosin 3 | -0.0172246 |
| PCNX1 | pecanex 1 | -0.0171906 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0171383 |
| RBM27 | RNA binding motif protein 27 | -0.0170971 |
| FAT1 | FAT atypical cadherin 1 | -0.0168707 |
| HMGB2 | high mobility group box 2 | -0.0168394 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0168277 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0167769 |
| NPHP3 | nephronophthisis 3 (adolescent) | -0.0167766 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.0167674 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0166831 |
| SGO2 | shugoshin 2 | -0.0165532 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0164864 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0164039 |
| AFTPH | aftiphilin | -0.0164003 |
| PRR11 | proline rich 11 | -0.0163681 |
| GRB2 | growth factor receptor-bound protein 2 | -0.0161852 |
| TBC1D15 | TBC1 domain family, member 15 | -0.0161771 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0157934 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0157859 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0157642 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -0.0156122 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0155982 |
| OLA1 | Obg-like ATPase 1 | -0.015448 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0152208 |
| HMGA1 | high mobility group AT-hook 1 | -0.0152193 |
| RACK1 | receptor for activated C kinase 1 | -0.0151442 |
| CDK17 | cyclin-dependent kinase 17 | -0.0150644 |
| USP24 | ubiquitin specific peptidase 24 | -0.0150513 |
| FMNL2 | formin-like 2 | -0.0150264 |
