Pemigatinib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pemigatinib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pemigatinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.346466
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.136666
NALF1 NALCN channel auxiliary factor 1 0.107179
TRIB2 tribbles pseudokinase 2 0.0877455
RPL23 ribosomal protein L23 0.0817954
RPL35A ribosomal protein L35a 0.0772529
LSAMP limbic system-associated membrane protein 0.0732906
RPL37A ribosomal protein L37a 0.0648877
VCL vinculin 0.0606014
PTPRD protein tyrosine phosphatase, receptor type, D 0.0574272
CADM2 cell adhesion molecule 2 0.0561087
ZSWIM6 zinc finger, SWIM-type containing 6 0.0531494
ACTG1 actin gamma 1 0.0517972
ASPH aspartate beta-hydroxylase 0.0511441
ADGRB3 adhesion G protein-coupled receptor B3 0.0489871
UNC5C unc-5 homolog C (C. elegans) 0.0473869
B2M beta-2-microglobulin 0.0457823
RPS6 ribosomal protein S6 0.0454804
TPT1 tumor protein, translationally-controlled 1 0.0450594
RPS23 ribosomal protein S23 0.0438324
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0412272
SLIT2 slit homolog 2 (Drosophila) 0.03968
FTL ferritin, light polypeptide 0.0377869
TPM1 tropomyosin 1 (alpha) 0.0365604
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0363352
LINGO2 leucine rich repeat and Ig domain containing 2 0.0353676
RAD51B RAD51 paralog B 0.0350912
FN1 fibronectin 1 0.0344146
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0338335
BPTF bromodomain PHD finger transcription factor 0.0337317
HOMER1 homer scaffolding protein 1 0.0327655
EGR1 early growth response 1 0.0326832
GLCCI1 glucocorticoid induced 1 0.032508
PDE4D phosphodiesterase 4D, cAMP-specific 0.0314761
STK38L serine/threonine kinase 38 like 0.0314386
RPLP0 ribosomal protein, large, P0 0.0312878
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0306994
IGFBP3 insulin-like growth factor binding protein 3 0.0305338
PTPRG protein tyrosine phosphatase, receptor type, G 0.0302652
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0298184
MT2A metallothionein 2A 0.0293645
ZNF609 zinc finger protein 609 0.0293521
DCAF7 DDB1 and CUL4 associated factor 7 0.0289716
ITGA1 integrin, alpha 1 0.0289375
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0288818
FHIT fragile histidine triad 0.0287851
RPS8 ribosomal protein S8 0.0285899
RPS10 ribosomal protein S10 0.0284813
RPL31 ribosomal protein L31 0.0284045
SIK2 salt-inducible kinase 2 0.0276749
DLC1 DLC1 Rho GTPase activating protein 0.027622
RPL13A ribosomal protein L13a 0.0273151
RPS14 ribosomal protein S14 0.0272229
EIF1 eukaryotic translation initiation factor 1 0.0266139
RPL19 ribosomal protein L19 0.0261876
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0258306
HLA-A major histocompatibility complex, class I, A 0.0257601
RPS13 ribosomal protein S13 0.0256467
RPS27 ribosomal protein S27 0.0256305
TMSB10 thymosin beta 10 0.0255128
BCAS3 breast carcinoma amplified sequence 3 0.0253944
CDH13 cadherin 13 0.0251867
MYO1E myosin IE 0.0249954
NPAS2 neuronal PAS domain protein 2 0.0249938
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.024939
RPL11 ribosomal protein L11 0.0248103
TLE4 transducin-like enhancer of split 4 0.0246175
LDHA lactate dehydrogenase A 0.0244591
SYT1 synaptotagmin I 0.0244277
TBX2 T-box 2 0.0242949
RPLP1 ribosomal protein, large, P1 0.0242218
DIAPH2 diaphanous-related formin 2 0.0239965
HLA-B major histocompatibility complex, class I, B 0.0238388
POTEF POTE ankyrin domain family, member F 0.023797
PAIP2 poly(A) binding protein interacting protein 2 0.0236525
EGFR epidermal growth factor receptor 0.0236373
TOB2 transducer of ERBB2, 2 0.0235199
SVIL supervillin 0.0235092
PRKCA protein kinase C, alpha 0.0230242
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0229637
RPL30 ribosomal protein L30 0.0229563
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0228995
RPS16 ribosomal protein S16 0.0226542
RPS15 ribosomal protein S15 0.0226025
PDLIM5 PDZ and LIM domain 5 0.0224176
EFNA5 ephrin-A5 0.0222718
TCF12 transcription factor 12 0.0220078
RHOA ras homolog family member A 0.0215266
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0213015
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0209548
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.020739
MCL1 myeloid cell leukemia 1 0.0205583
TBCA tubulin folding cofactor A 0.0203833
LPP LIM domain containing preferred translocation partner in lipoma 0.0203636
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0203093
PDE10A phosphodiesterase 10A 0.020294
SLC38A2 solute carrier family 38, member 2 0.0201977
TIMP2 TIMP metallopeptidase inhibitor 2 0.0201432
CUX1 cut-like homeobox 1 0.0201234
ZRANB3 zinc finger, RAN-binding domain containing 3 0.0200253

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.148713
IGF2 insulin-like growth factor 2 -0.121645
HELZ helicase with zinc finger -0.106994
FAM13A family with sequence similarity 13, member A -0.0926592
OGA O-GlcNAcase -0.0747052
PTMA prothymosin, alpha -0.0732939
FNDC3B fibronectin type III domain containing 3B -0.065862
DSCAM Down syndrome cell adhesion molecule -0.0627166
MEIS2 Meis homeobox 2 -0.0619789
KDM3A lysine (K)-specific demethylase 3A -0.0614738
NPEPPS aminopeptidase puromycin sensitive -0.0581846
SOS1 son of sevenless homolog 1 (Drosophila) -0.0555887
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0547797
FNBP1 formin binding protein 1 -0.0541131
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0540747
MARCHF6 membrane associated ring-CH-type finger 6 -0.0531678
COL3A1 collagen, type III, alpha 1 -0.0526648
APP amyloid beta (A4) precursor protein -0.0521836
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0516374
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0503015
NRG1 neuregulin 1 -0.0490984
HMGB2 high mobility group box 2 -0.0483714
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0475568
HIP1 huntingtin interacting protein 1 -0.0468915
CLTC clathrin, heavy chain (Hc) -0.0465485
ARID4B AT rich interactive domain 4B (RBP1-like) -0.045366
SPAG9 sperm associated antigen 9 -0.0452201
NIPBL Nipped-B homolog (Drosophila) -0.0438007
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0435656
MEF2A myocyte enhancer factor 2A -0.04345
NAMPT nicotinamide phosphoribosyltransferase -0.0427119
UBE2O ubiquitin-conjugating enzyme E2O -0.0424997
WAC WW domain containing adaptor with coiled-coil -0.0420239
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0417494
NCAM2 neural cell adhesion molecule 2 -0.0412319
NEK7 NIMA-related kinase 7 -0.0410211
WDR45B WD repeat domain 45B -0.0408895
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0402401
KMT2E lysine (K)-specific methyltransferase 2E -0.039844
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0397055
KMT2C lysine (K)-specific methyltransferase 2C -0.0396787
SEPTIN2 septin 2 -0.0388574
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0384836
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0382655
PCM1 pericentriolar material 1 -0.0382004
GARS1 glycyl-tRNA synthetase 1 -0.0371087
SBF2 SET binding factor 2 -0.0371019
TENT5A terminal nucleotidyltransferase 5A -0.0369057
ZC3H11A zinc finger CCCH-type containing 11A -0.0367005
CDC27 cell division cycle 27 -0.036272
PLAT plasminogen activator, tissue -0.0358229
MSI2 musashi RNA-binding protein 2 -0.035652
CADM1 cell adhesion molecule 1 -0.0346708
ADGRG6 adhesion G protein-coupled receptor G6 -0.0346406
MYH10 myosin, heavy chain 10, non-muscle -0.0342045
TPR translocated promoter region, nuclear basket protein -0.0338165
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0335485
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0335121
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0334048
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0333729
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0333088
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0326562
PSD3 pleckstrin and Sec7 domain containing 3 -0.0324963
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0324191
PUM2 pumilio RNA-binding family member 2 -0.0323805
FOXK2 forkhead box K2 -0.0320435
MBNL2 muscleblind-like splicing regulator 2 -0.0319869
HAND2 heart and neural crest derivatives expressed 2 -0.031901
RPS2 ribosomal protein S2 -0.031453
TMF1 TATA element modulatory factor 1 -0.031416
PTK2 protein tyrosine kinase 2 -0.0313976
NRIP1 nuclear receptor interacting protein 1 -0.0313394
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0313237
LCORL ligand dependent nuclear receptor corepressor-like -0.0312114
COPA coatomer protein complex, subunit alpha -0.0309096
CASC3 cancer susceptibility candidate 3 -0.0308722
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0305676
SEC24D SEC24 family member D -0.0303273
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0297226
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0296185
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0294042
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0292292
GOLGA4 golgin A4 -0.0290443
TCERG1 transcription elongation regulator 1 -0.0290272
NCOR1 nuclear receptor corepressor 1 -0.0287825
PHIP pleckstrin homology domain interacting protein -0.028629
TENT2 terminal nucleotidyltransferase 2 -0.0283662
QKI QKI, KH domain containing, RNA binding -0.0282548
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0281831
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0279436
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0278455
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0277893
C1ORF21 chromosome 1 open reading frame 21 -0.0276441
CHD9 chromodomain helicase DNA binding protein 9 -0.027533
LMNA lamin A/C -0.027235
YTHDC1 YTH domain containing 1 -0.0270072
XPO1 exportin 1 -0.026855
TLK2 tousled-like kinase 2 -0.0262114
CEP95 centrosomal protein 95kDa -0.0259151
DENND4C DENN/MADD domain containing 4C -0.0258593