| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemigatinib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pemigatinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.192126 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.167201 |
| FNDC3B | fibronectin type III domain containing 3B | 0.164837 |
| NDRG1 | N-myc downstream regulated 1 | 0.15011 |
| CADM1 | cell adhesion molecule 1 | 0.140352 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.136318 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.113432 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0879277 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0811803 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0719206 |
| PTK2 | protein tyrosine kinase 2 | 0.0705575 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0690711 |
| EGFR | epidermal growth factor receptor | 0.068831 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0685671 |
| RIGI | RNA sensor RIG-I | 0.0659628 |
| LOXL2 | lysyl oxidase-like 2 | 0.0640339 |
| FMNL2 | formin-like 2 | 0.0600136 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.059663 |
| SP100 | SP100 nuclear antigen | 0.0589553 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0586855 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0552255 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0549603 |
| FNIP1 | folliculin interacting protein 1 | 0.0525948 |
| MRTFA | myocardin related transcription factor A | 0.0516129 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0513397 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0507434 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.049495 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0489946 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0488262 |
| TFG | TRK-fused gene | 0.0470676 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0468474 |
| SEC24A | SEC24 family member A | 0.0459498 |
| VCAN | versican | 0.0448444 |
| GOLGB1 | golgin B1 | 0.0447488 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0436788 |
| SPAG9 | sperm associated antigen 9 | 0.0432583 |
| ATP13A3 | ATPase type 13A3 | 0.0431285 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0422153 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0419298 |
| PDE10A | phosphodiesterase 10A | 0.0414844 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0403328 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0393567 |
| COG5 | component of oligomeric golgi complex 5 | 0.0393107 |
| YEATS2 | YEATS domain containing 2 | 0.0392045 |
| DOCK7 | dedicator of cytokinesis 7 | 0.0390613 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0383777 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0370635 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.037049 |
| NOP58 | NOP58 ribonucleoprotein | 0.0367433 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0364001 |
| GOLGA4 | golgin A4 | 0.0363397 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0362731 |
| ATP11B | ATPase, class VI, type 11B | 0.0361339 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0360729 |
| DYM | dymeclin | 0.0353431 |
| CCNY | cyclin Y | 0.0351928 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0351783 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0351781 |
| MAP4 | microtubule-associated protein 4 | 0.0344934 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0340247 |
| ATXN1 | ataxin 1 | 0.0338682 |
| SQSTM1 | sequestosome 1 | 0.0335311 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.033361 |
| IL6ST | interleukin 6 signal transducer | 0.0332885 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0330085 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0328308 |
| SETD5 | SET domain containing 5 | 0.032822 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0322991 |
| SEC24D | SEC24 family member D | 0.032205 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0318297 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0317609 |
| CLINT1 | clathrin interactor 1 | 0.0314407 |
| PARD3 | par-3 family cell polarity regulator | 0.0311676 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0307793 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0305981 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0303787 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0303365 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0300653 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.030047 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0298979 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0295505 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0294974 |
| ZNF292 | zinc finger protein 292 | 0.0291873 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.028983 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0289001 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0287062 |
| DENND5A | DENN/MADD domain containing 5A | 0.0284474 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0282259 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0281873 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0281588 |
| SUCO | SUN domain containing ossification factor | 0.0281165 |
| HM13 | histocompatibility (minor) 13 | 0.0277878 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0276576 |
| VMP1 | vacuole membrane protein 1 | 0.0276531 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0274216 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.027059 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0269377 |
| RASA2 | RAS p21 protein activator 2 | 0.0267187 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0266507 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0266149 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.0919764 |
| CD44 | CD44 molecule (Indian blood group) | -0.0902506 |
| COL1A1 | collagen, type I, alpha 1 | -0.0899558 |
| HMGA2 | high mobility group AT-hook 2 | -0.0808759 |
| COL1A2 | collagen, type I, alpha 2 | -0.0626095 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0563071 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0553426 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0534678 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0515725 |
| STC1 | stanniocalcin 1 | -0.0505314 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0504387 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0471621 |
| GLIS3 | GLIS family zinc finger 3 | -0.0446984 |
| NAV1 | neuron navigator 1 | -0.0361229 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0355745 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0351269 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0328813 |
| TPM4 | tropomyosin 4 | -0.0301378 |
| FBN1 | fibrillin 1 | -0.0297728 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0290586 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0287743 |
| OSMR | oncostatin M receptor | -0.0286726 |
| TMSB10 | thymosin beta 10 | -0.0283203 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0279962 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0278102 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.0275412 |
| NRP1 | neuropilin 1 | -0.0275125 |
| CDH13 | cadherin 13 | -0.027065 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0268728 |
| ACTG1 | actin gamma 1 | -0.0265471 |
| FTL | ferritin, light polypeptide | -0.0247644 |
| MT2A | metallothionein 2A | -0.0240702 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0240534 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0236746 |
| FRMD4A | FERM domain containing 4A | -0.023585 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0232273 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0230364 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0227323 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0225318 |
| NREP | neuronal regeneration related protein | -0.0224695 |
| MAP1B | microtubule-associated protein 1B | -0.0224412 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0219858 |
| HLA-B | major histocompatibility complex, class I, B | -0.0216918 |
| PALLD | palladin, cytoskeletal associated protein | -0.0215781 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0214056 |
| MYO9A | myosin IXA | -0.0213392 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0213089 |
| PRSS23 | protease, serine, 23 | -0.0212278 |
| COL3A1 | collagen, type III, alpha 1 | -0.0206804 |
| FN1 | fibronectin 1 | -0.0206063 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0196003 |
| EGR1 | early growth response 1 | -0.0195085 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0193065 |
| EHBP1 | EH domain binding protein 1 | -0.0189818 |
| CALD1 | caldesmon 1 | -0.0188816 |
| CENPF | centromere protein F, 350/400kDa | -0.0187227 |
| ZFHX3 | zinc finger homeobox 3 | -0.0184562 |
| KLF6 | Kruppel-like factor 6 | -0.0179667 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0177243 |
| MKI67 | marker of proliferation Ki-67 | -0.0173907 |
| POSTN | periostin, osteoblast specific factor | -0.017234 |
| DSTN | destrin (actin depolymerizing factor) | -0.0171974 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0167608 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0167044 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0164208 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0163342 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0163072 |
| ATXN10 | ataxin 10 | -0.016302 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0162197 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0162111 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0161702 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.015882 |
| DST | dystonin | -0.0154429 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.015293 |
| TENM3 | teneurin transmembrane protein 3 | -0.0151697 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0151281 |
| RPS24 | ribosomal protein S24 | -0.015118 |
| MYLK | myosin light chain kinase | -0.0148422 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0147808 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0146839 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0146806 |
| CCDC88A | coiled-coil domain containing 88A | -0.0146314 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0146296 |
| SULF1 | sulfatase 1 | -0.0142597 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0140123 |
| PPARA | peroxisome proliferator-activated receptor alpha | -0.013762 |
| TMSB4X | thymosin beta 4, X-linked | -0.0137137 |
| MTSS1 | metastasis suppressor 1 | -0.0135316 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0134583 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0134484 |
| GPR141 | G protein-coupled receptor 141 | -0.0131963 |
| EMP1 | epithelial membrane protein 1 | -0.0131951 |
| PYGL | phosphorylase, glycogen, liver | -0.0131792 |
| ATM | ATM serine/threonine kinase | -0.0130606 |
| IFI44 | interferon-induced protein 44 | -0.0130172 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0129748 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0128472 |
| LMO4 | LIM domain only 4 | -0.0127122 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.012675 |
| HMCN1 | hemicentin 1 | -0.0125838 |
