| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemigatinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemigatinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.242245 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.165813 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.121469 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.11521 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.111184 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.110961 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0999927 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0975105 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0956311 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0916177 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0911478 |
| SVIL | supervillin | 0.0854712 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0827168 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.079071 |
| FNDC3B | fibronectin type III domain containing 3B | 0.070865 |
| DTNA | dystrobrevin, alpha | 0.068283 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0655878 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0646739 |
| AHSG | alpha-2-HS-glycoprotein | 0.0611875 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0603232 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0597682 |
| ATXN1 | ataxin 1 | 0.059037 |
| CRY1 | cryptochrome circadian clock 1 | 0.0574054 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0572772 |
| GPC3 | glypican 3 | 0.0569666 |
| CLIC4 | chloride intracellular channel 4 | 0.0555847 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0542932 |
| KIF13A | kinesin family member 13A | 0.0521557 |
| PDE8A | phosphodiesterase 8A | 0.0517166 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0506777 |
| ITGAV | integrin, alpha V | 0.0498927 |
| FBXO42 | F-box protein 42 | 0.0468644 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0465726 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0462848 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0460285 |
| MED13L | mediator complex subunit 13-like | 0.0455124 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0447148 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0444782 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0444131 |
| LDHA | lactate dehydrogenase A | 0.0442659 |
| AFDN | afadin, adherens junction formation factor | 0.0439846 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0436128 |
| MYO1B | myosin IB | 0.0435771 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0425028 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0424029 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0422531 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0419451 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0405561 |
| IQSEC1 | IQ motif and Sec7 domain 1 | 0.0401848 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0397874 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0394368 |
| LPIN2 | lipin 2 | 0.0381784 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0381739 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0377536 |
| UBQLN1 | ubiquilin 1 | 0.0376967 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0376932 |
| RAB10 | RAB10, member RAS oncogene family | 0.0371258 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0371231 |
| TOP1 | topoisomerase (DNA) I | 0.0362629 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.035802 |
| FAM13A | family with sequence similarity 13, member A | 0.0357953 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0355276 |
| PKP4 | plakophilin 4 | 0.0350341 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0349701 |
| KIF5B | kinesin family member 5B | 0.0344948 |
| GOLGA4 | golgin A4 | 0.033955 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0338502 |
| PUM2 | pumilio RNA-binding family member 2 | 0.033834 |
| FOXP1 | forkhead box P1 | 0.0331062 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0330269 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0329799 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0328948 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.0327047 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0320699 |
| BSG | basigin (Ok blood group) | 0.0319679 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0316842 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0315106 |
| EZR | ezrin | 0.0313705 |
| GOLM2 | golgi membrane protein 2 | 0.0313341 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0308398 |
| QKI | QKI, KH domain containing, RNA binding | 0.0306558 |
| OLA1 | Obg-like ATPase 1 | 0.0306041 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.03053 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0304193 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0302087 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0297214 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0294447 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0292973 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0292563 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0291818 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0288863 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0288837 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0287953 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0287327 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0286129 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0283225 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0282966 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0281922 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0279962 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0279348 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | -0.0960649 |
| EHBP1 | EH domain binding protein 1 | -0.0837 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0745755 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0725605 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0677885 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0625785 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0618883 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0612621 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0596025 |
| RRBP1 | ribosome binding protein 1 | -0.0573871 |
| FN1 | fibronectin 1 | -0.0567538 |
| TMEM123 | transmembrane protein 123 | -0.0546454 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0539514 |
| RPS27A | ribosomal protein S27a | -0.0488781 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0458782 |
| VCL | vinculin | -0.045267 |
| MCL1 | myeloid cell leukemia 1 | -0.0452095 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0444742 |
| CP | ceruloplasmin (ferroxidase) | -0.043897 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0435291 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0418026 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0391269 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0386538 |
| PTCHD4 | patched domain containing 4 | -0.038314 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0378739 |
| APOB | apolipoprotein B | -0.0376873 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0372655 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0357279 |
| APOA2 | apolipoprotein A-II | -0.0354964 |
| ITGA1 | integrin, alpha 1 | -0.035422 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0344287 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0342306 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0341981 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0337416 |
| FTL | ferritin, light polypeptide | -0.0333916 |
| FILIP1L | filamin A interacting protein 1-like | -0.0333452 |
| PGK1 | phosphoglycerate kinase 1 | -0.0329994 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0317369 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0301514 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0301252 |
| PEG10 | paternally expressed 10 | -0.0300774 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0294401 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0287769 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0286118 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | -0.0284029 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.0277742 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0272131 |
| OSMR | oncostatin M receptor | -0.0271855 |
| NDRG1 | N-myc downstream regulated 1 | -0.0270547 |
| GK | glycerol kinase | -0.0268891 |
| BCL2L1 | BCL2-like 1 | -0.0268055 |
| RPL9 | ribosomal protein L9 | -0.026571 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0260534 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0257901 |
| TUT4 | terminal uridylyl transferase 4 | -0.0254595 |
| NHSL1 | NHS-like 1 | -0.0254118 |
| RNF213 | ring finger protein 213 | -0.0254106 |
| MALT1 | MALT1 paracaspase | -0.0252283 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0248063 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.024611 |
| C3 | complement component 3 | -0.0244914 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0244802 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0244382 |
| PRELID2 | PRELI domain containing 2 | -0.0243448 |
| CFB | complement factor B | -0.0241005 |
| ATM | ATM serine/threonine kinase | -0.0240848 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0237119 |
| RIGI | RNA sensor RIG-I | -0.0236635 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0236347 |
| ECE1 | endothelin converting enzyme 1 | -0.0234829 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0233754 |
| KLHL5 | kelch-like family member 5 | -0.0233002 |
| UBXN4 | UBX domain protein 4 | -0.0232678 |
| RPL31 | ribosomal protein L31 | -0.0231934 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0231551 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0230628 |
| ARF1 | ADP-ribosylation factor 1 | -0.0230111 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.023009 |
| ZFHX3 | zinc finger homeobox 3 | -0.022876 |
| RPL36 | ribosomal protein L36 | -0.0228145 |
| DOK6 | docking protein 6 | -0.0225464 |
| MSI2 | musashi RNA-binding protein 2 | -0.0225212 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.022481 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0221874 |
| KDM3B | lysine (K)-specific demethylase 3B | -0.022032 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0220095 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.021998 |
| TMSB10 | thymosin beta 10 | -0.0212935 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0209561 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0208552 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | -0.0203159 |
| UTRN | utrophin | -0.0203156 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0202954 |
| DNAAF9 | dynein axonemal assembly factor 9 | -0.0202712 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0201858 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0201428 |
| C5 | complement component 5 | -0.0197899 |
| SMAD3 | SMAD family member 3 | -0.0195535 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0195311 |
| TPM1 | tropomyosin 1 (alpha) | -0.0192405 |
