| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemigatinib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pemigatinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.278366 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.147479 |
| PTMA | prothymosin, alpha | 0.115796 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.112755 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.101496 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0848081 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0676725 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0651423 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0649535 |
| LDHA | lactate dehydrogenase A | 0.0614505 |
| AFF1 | AF4/FMR2 family, member 1 | 0.059671 |
| GOLGA4 | golgin A4 | 0.0575421 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0545938 |
| MED13 | mediator complex subunit 13 | 0.0521761 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0507682 |
| TRIM2 | tripartite motif containing 2 | 0.0499149 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0496018 |
| FTL | ferritin, light polypeptide | 0.0492609 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.049007 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0486253 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0480341 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.047504 |
| NEBL | nebulette | 0.0462585 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0444539 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.0442955 |
| TXNIP | thioredoxin interacting protein | 0.043224 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0424723 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0417533 |
| ITGA6 | integrin, alpha 6 | 0.0413544 |
| ZNRF3 | zinc and ring finger 3 | 0.0404582 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0403704 |
| PDZD8 | PDZ domain containing 8 | 0.0402175 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0388012 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0383069 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0381569 |
| RHOA | ras homolog family member A | 0.0366576 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0363108 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0360242 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0357366 |
| PTEN | phosphatase and tensin homolog | 0.0354505 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.0345144 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0344202 |
| FNDC3B | fibronectin type III domain containing 3B | 0.033862 |
| MATR3 | matrin 3 | 0.0337853 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0332515 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0329816 |
| EPCAM | epithelial cell adhesion molecule | 0.0328967 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0326407 |
| CADPS | Ca++-dependent secretion activator | 0.0323301 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0319774 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0312782 |
| WHRN | whirlin | 0.0310847 |
| ATXN1 | ataxin 1 | 0.0309751 |
| CD2AP | CD2-associated protein | 0.0307705 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0306758 |
| CENPF | centromere protein F, 350/400kDa | 0.0303175 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0301642 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0300677 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0299248 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0291528 |
| TPI1 | triosephosphate isomerase 1 | 0.0290046 |
| BRD2 | bromodomain containing 2 | 0.0285841 |
| RNF145 | ring finger protein 145 | 0.0281704 |
| GPBP1L1 | GC-rich promoter binding protein 1-like 1 | 0.0281207 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0279047 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0278119 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0275164 |
| TUBA1B | tubulin, alpha 1b | 0.0272994 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0271836 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0269414 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0264055 |
| ETNK1 | ethanolamine kinase 1 | 0.0263617 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0262083 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0261069 |
| CRY1 | cryptochrome circadian clock 1 | 0.0259997 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.025602 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0254455 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0253007 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0251219 |
| SSR1 | signal sequence receptor, alpha | 0.0250846 |
| EPHB2 | EPH receptor B2 | 0.0250632 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0245947 |
| TMEM123 | transmembrane protein 123 | 0.0245933 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0242948 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0242882 |
| NBAS | neuroblastoma amplified sequence | 0.0241775 |
| JUN | jun proto-oncogene | 0.0238077 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0237002 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0234951 |
| PRELID2 | PRELI domain containing 2 | 0.0234198 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0232537 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0232027 |
| MAP4 | microtubule-associated protein 4 | 0.0228973 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0227487 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0227167 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0226988 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0226941 |
| RLF | rearranged L-myc fusion | 0.0226421 |
| NUP58 | nucleoporin 58 | 0.0226278 |
| CDK6 | cyclin-dependent kinase 6 | 0.0226105 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.182409 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.181241 |
| VCL | vinculin | -0.0839098 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0807396 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0774815 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0687698 |
| FLNB | filamin B, beta | -0.0657892 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0637024 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0587913 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0574058 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0511497 |
| ANXA2 | annexin A2 | -0.0496307 |
| LAMA4 | laminin, alpha 4 | -0.0489874 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0487583 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0487317 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0478955 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0474578 |
| TNS4 | tensin 4 | -0.0463012 |
| TPM4 | tropomyosin 4 | -0.0459841 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0437341 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0434996 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0426996 |
| EGFR | epidermal growth factor receptor | -0.0408107 |
| PALLD | palladin, cytoskeletal associated protein | -0.0399679 |
| IER3 | immediate early response 3 | -0.0396821 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.0386169 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0374266 |
| KIAA1217 | KIAA1217 | -0.0367712 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0365439 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0364766 |
| KLK10 | kallikrein-related peptidase 10 | -0.0361952 |
| LYZ | lysozyme | -0.035503 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0347494 |
| LAMB3 | laminin, beta 3 | -0.0344351 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0324877 |
| SPON1 | spondin 1, extracellular matrix protein | -0.032471 |
| SH3D19 | SH3 domain containing 19 | -0.0314875 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0304587 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0302382 |
| HMGA1 | high mobility group AT-hook 1 | -0.0298981 |
| TMSB10 | thymosin beta 10 | -0.0298027 |
| NDRG1 | N-myc downstream regulated 1 | -0.0296203 |
| ATXN7L1 | ataxin 7-like 1 | -0.0296164 |
| BCL2L1 | BCL2-like 1 | -0.0295928 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0295476 |
| RPL9 | ribosomal protein L9 | -0.0290221 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0286775 |
| RNF217 | ring finger protein 217 | -0.0282119 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0277904 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0277294 |
| S100P | S100 calcium binding protein P | -0.0270415 |
| RPS8 | ribosomal protein S8 | -0.027038 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0270075 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0268937 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.02683 |
| FHL2 | four and a half LIM domains 2 | -0.0265055 |
| KRT18 | keratin 18, type I | -0.0261136 |
| DOCK5 | dedicator of cytokinesis 5 | -0.025726 |
| ICA1 | islet cell autoantigen 1, 69kDa | -0.0255309 |
| AGR2 | anterior gradient 2 | -0.0250814 |
| ACTG1 | actin gamma 1 | -0.0250084 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0249127 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0246658 |
| INTS6 | integrator complex subunit 6 | -0.0244351 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0240977 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0238282 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0235486 |
| RPL12 | ribosomal protein L12 | -0.0234413 |
| AHNAK | AHNAK nucleoprotein | -0.0234237 |
| ANXA3 | annexin A3 | -0.0233525 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0231652 |
| RPL35A | ribosomal protein L35a | -0.0231571 |
| CNKSR3 | CNKSR family member 3 | -0.0231215 |
| IRS2 | insulin receptor substrate 2 | -0.0227779 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0226347 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.0223799 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0220996 |
| RPS27A | ribosomal protein S27a | -0.0220665 |
| CCND1 | cyclin D1 | -0.0220475 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0220224 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.0218421 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0217756 |
| HDAC2 | histone deacetylase 2 | -0.0215619 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0215232 |
| ABR | active BCR-related | -0.0214639 |
| FMNL2 | formin-like 2 | -0.0212325 |
| RIN2 | Ras and Rab interactor 2 | -0.0210333 |
| KRT8 | keratin 8, type II | -0.0208714 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0207994 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0207536 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.020509 |
| ARHGAP6 | Rho GTPase activating protein 6 | -0.0203309 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0199781 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0198458 |
| ITGB4 | integrin, beta 4 | -0.0197762 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0195598 |
| TPM1 | tropomyosin 1 (alpha) | -0.019509 |
| MYO1D | myosin ID | -0.019437 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0192107 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0191528 |
